List of works by Mark R. Boyett

'And the beat goes on.' The cardiac conduction system: the wiring system of the heart.

scientific article published on 10 July 2009

3D virtual human atria: A computational platform for studying clinical atrial fibrillation

scientific article published on 7 July 2011

A computer simulation of the effect of heart rate on ion concentrations in the heart.

scientific article published in May 1988

A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels

scientific article published on 18 August 2005

A simple electronic circuit for determining the twitch force and resting force of small heart muscle preparations.

scientific article published in October 1987

A simple electronic circuit for monitoring changes in the duration of the action potential

scientific article published on 01 August 1983

Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking

article

Ageing-related changes of connexins and conduction within the sinoatrial node.

scientific article published on 12 August 2004

An analysis of the effect of the rate of stimulation and adrenaline on the duration of the cardiac action potential ⬇️

scientific article published on November 14, 1978

An improved apparatus for the optical recording of contraction of single heart cells.

scientific article published in December 1988

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

scientific article

Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks

scientific article published on 29 June 2011

Anger, emotion, and arrhythmias: from brain to heart

scientific article published on 19 October 2011

Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development

scientific article

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study.

scientific article published in October 2008

Barium block of the muscarinic potassium current in guinea-pig atrial cells.

scientific article published in July 1995

Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4.

scientific article

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

scientific article (publication date: 2013)

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate

scientific article

Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction.

scientific article published on 12 May 2011

Changes in the electrical activity of dog cardiac Purkinje fibres at high heart rates

scientific article published on 01 May 1984

Changes in the expression of ion channels, connexins and Ca2+-handling proteins in the sino-atrial node during postnatal development.

scientific article published on 28 January 2011

Characterisation of the transient outward K+ current in rabbit sinoatrial node cells

scientific article published on 01 June 2000

Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression

scientific article

Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

scientific article published on August 2007

Chronic effects of mild hyperglycaemia on left ventricle transcriptional profile and structural remodelling in the spontaneously type 2 diabetic Goto-Kakizaki rat.

scientific article

Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy

scientific article published on 01 January 2015

Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving

scientific article published on 28 July 2006

Computer simulation of the electrotonic modulation of pacemaker activity in the sinoatrial node by atrial muscle.

scientific article published in January 1995

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

scientific article

Computer three-dimensional reconstruction of the atrioventricular node

scientific article

Computer three-dimensional reconstruction of the sinoatrial node.

scientific article published on 7 February 2005

Connexins in the sinoatrial and atrioventricular nodes.

scientific article

Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts

scientific article

Contribution of potassium accumulation in narrow extracellular spaces to the genesis of nicorandil-induced large inward tail current in guinea-pig ventricular cells

scientific article published in January 1993

Control of the cardiac muscarinic K+ channel by beta-arrestin 2.

scientific article published on 10 January 2001

Cow ventricular muscle. I. The effect of the extracellular potassium concentration on the current-voltage relationship. II. Evidence for a time-dependent outward current.

scientific article published in December 1980

CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed

scientific article published on 21 April 2019

CrossTalk opposing view: bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node.

scientific article published on April 2015

Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry

scientific article published on 30 January 2003

Cyclical modulation of human ventricular repolarization by respiration.

scientific article published on 24 September 2012

Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node

scientific article published on 5 March 2007

Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects

scientific article published on 24 June 2014

Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit

scientific article published on 02 November 2006

Dissociation between force and intracellular sodium activity with strophanthidin in isolated sheep Purkinje fibres

scientific article published on 01 December 1986

Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.

scientific article published on 27 July 2006

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

scientific article published on 24 April 2009

Effect of adrenergic stimulation on action potential duration restitution in humans.

scientific article published in January 2003

Effect of extracellular cations on the inward rectifying K+ channels Kir2.1 and Kir3.1/Kir3.4.

scientific article published in May 1999

Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes

scientific article published on 01 April 1999

Effects of glyburide (glibenclamide) on myocardial function in Langendorff perfused rabbit heart and on myocardial contractility and slow calcium current in guinea-pig single myocytes.

scientific article published in January 2003

Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle

scientific article published on 16 July 2008

Electrophysiological substrate for a dominant reentrant source during atrial fibrillation

scientific article published on 01 January 2009

Evidence for multiple Src binding sites on the alpha1c L-type Ca2+ channel and their roles in activity regulation

scientific journal article

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

scientific article

Expression of Kir2.1 and Kir6.2 transgenes under the control of the α-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice

scientific article published on 22 September 2006

Expression, purification and spectroscopic studies of full-length Kir3.1 channel C-terminus

scientific article

Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45

scientific article published on 02 August 2006

Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

scientific article published on April 2013

Heterogeneous expression of connexins in rabbit sinoatrial node cells: correlation between connexin isotype and cell size

scientific article published in January 2002

Heterogeneous expression of the delayed-rectifier K+ currents i(K,r) and i(K,s) in rabbit sinoatrial node cells

scientific article

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

scientific article published on 26 October 2012

Imaging the heart: computer 3-dimensional anatomic models of the heart

scientific article

Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing

scientific article

Influence of Ca2+ channel agonists and antagonists on the post-rest staircase

scientific article

Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control

scientific article

Ion channel transcript expression at the rabbit atrioventricular conduction axis.

scientific article

Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node

scientific article published on 01 June 1995

Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells

scientific article

Left ventricle structural remodelling in the prediabetic Goto-Kakizaki rat.

scientific article published on 27 May 2011

Letter by Anderson et al Regarding Article, “Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor”

scientific article published on 01 August 2008

Letter by Monfredi et al regarding article, "Physical activity and heart rate variability in older adults: the cardiovascular health study"

scientific article published on 01 February 2015

Letter by Morris et al regarding article, "Low heart rates predict incident atrial fibrillation in healthy middle-aged men" by Grundvold et al

scientific article published on 01 December 2013

Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat

scientific journal article

Macitentan treatment retards the progression of established pulmonary arterial hypertension in an animal model.

scientific article published on 11 October 2014

Mathematical models of the electrical action potential of Purkinje fibre cells.

scientific article published in June 2009

Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy

scientific article published on February 2009

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.

scientific article

Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

scientific article published on 28 March 2011

Modeling the chronotropic effect of isoprenaline on rabbit sinoatrial node

scientific article

Modelling the pH-dependent Properties of Kv1 Potassium Channels

scientific article published on 22 February 2007

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

scientific article published on 16 March 2009

Molecular architecture of the human specialised atrioventricular conduction axis

scientific article published on 21 January 2011

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

scientific article

Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animals

scientific article published on 26 July 2011

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells.

scientific article published on October 2009

Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction.

scientific article published in July 2009

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

scientific article published on 15 November 2006

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

scientific article published on 21 February 2009

Pacemaker shift in the rabbit sinoatrial node in response to vagal nerve stimulation

scientific article published on 01 March 2001

Perspectives -- biological pacing, a clinical reality?

scientific article published on 28 August 2009

Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle

scientific article published on 17 April 2012

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling.

scientific article published on 16 April 2012

Rapid effects of cytochalasin-D on contraction and intracellular calcium in single rat ventricular myocytes.

scientific article published in October 1998

Rebuttal from Alicia D'Souza, Sanjay Sharma and Mark R. Boyett

scientific article published on 01 April 2015

Rebuttal from Mark Boyett, Yanwen Wang and Alicia D'Souza

scientific article published on 21 April 2019

Regional differences in the electrical activity of the rabbit sinus node

scientific article published in July 1985

Reply to Matelot, Schnell, Kervio, Thillaye du Boullay, and Carre

scientific article

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

scientific article published on 14 July 2004

Residues and mechanisms for slow activation and Ba2+ block of the cardiac muscarinic K+ channel, Kir3.1/Kir3.4.

scientific article published in November 2000

Response: Optimal Velocity Can Arise from Various Discontinuities.

scientific article

Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart

scientific article published on 29 September 2006

Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node

scientific article published on 10 August 2007

Role of receptor kinase in short-term desensitization of cardiac muscarinic K+ channels expressed in Chinese hamster ovary cells

scientific article published on 01 March 1998

Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.

scientific article

Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte.

scientific article

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

scientific article published on 09 July 2020

Simulation study of complex action potential conduction in atrioventricular node

scientific article published in January 2013

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart

scientific article published on 16 October 2003

Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function

scientific article

Stochastic vagal modulation of cardiac pacemaking may lead to erroneous identification of cardiac "chaos".

scientific article published in June 2009

Structural and functional alterations in the atrioventricular node and atrioventricular ring tissue in ischaemia-induced heart failure.

scientific article

Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues.

scientific article published on 20 April 2013

Structure-function relationship in the AV junction

scientific article published in October 2004

TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.

scientific article published on 14 April 2011

The Selectivity Filter May Act as the Agonist-activated Gate in the G Protein-activated Kir3.1/Kir3.4 K+ Channel ⬇️

scientific article published on October 2, 2003

The anatomy and physiology of the sinoatrial node--a contemporary review

scientific article

The anatomy of the cardiac conduction system

scientific article published on January 2009

The anatomy of the conduction system: implications for the clinical cardiologist

scientific article published on 15 December 2012

The cellular actions of digitalis glycosides on the heart.

scientific article published on January 1994

The extent of the specialized atrioventricular ring tissues

scientific article published on 21 January 2009

The role of Na(+)-Ca2+ exchange current in electrical restitution in ferret ventricular cells.

scientific article published in October 1997

The sinoatrial node is still setting the pace 100 years after its discovery.

scientific article

The sinoatrial node: cell size does matter

scientific article published in September 2007

Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours

scientific article

Viewpoint: Is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone?

scientific article published on 03 January 2013

What do we learn from double Cx40/Cx45-deficient mice about cardiac morphogenetic defects and conduction abnormalities?

scientific article published on 02 October 2006

hERG inhibitors with similar potency but different binding kinetics do not pose the same proarrhythmic risk: implications for drug safety assessment

scientific article published on 7 October 2013

Paulina is supported by:

About Paulina

Help