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List of works by Halina Dobrzynski

3D anatomical reconstruction of human cardiac conduction system and simulation of bundle branch block after TAVI procedure.

scientific article published on August 2016

3D virtual human atria: A computational platform for studying clinical atrial fibrillation

scientific article published on 7 July 2011

A detailed 3D model of the rabbit right atrium including the sinoatrial node, atrioventricular node, surrounding blood vessels and valves

A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node

scientific article published on 10 April 2019

Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking

article

Altered profile of mRNA expression in atrioventricular node of streptozotocin‑induced diabetic rats.

scientific article

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

scientific article

Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks

scientific article published on 29 June 2011

Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. ⬇️

scientific article published in December 2016

Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance

scientific article published on 02 June 2016

Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size

scientific article published on 24 May 2007

Cellular Mechanisms of Sinoatrial Activity

Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction.

scientific article published on 12 May 2011

Changes in the expression of ion channels, connexins and Ca2+-handling proteins in the sino-atrial node during postnatal development

scientific article published on 28 January 2011

Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression

scientific article

Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

scientific article published on August 2007

Chronic effects of mild hyperglycaemia on left ventricle transcriptional profile and structural remodelling in the spontaneously type 2 diabetic Goto-Kakizaki rat.

scientific article

Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms

scientific article published on 29 August 2018

Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy

scientific article published on 01 January 2015

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart

scientific article

Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving

scientific article published on 28 July 2006

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

scientific article

Computer three-dimensional reconstruction of the atrioventricular node

scientific article

Computer three-dimensional reconstruction of the sinoatrial node

scientific article published on 7 February 2005

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

scientific article (publication date: 2015)

Connexins and the atrioventricular node ⬇️

scientific article published on October 22, 2012

Connexins in the sinoatrial and atrioventricular nodes.

scientific article

Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects

scientific article published on 24 June 2014

Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat

scientific article

Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit

scientific article published on 02 November 2006

Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.

scientific article published on 27 July 2006

Distribution of atrial natriuretic peptide and its effects on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rat.

scientific article

Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node.

scientific article published on 24 April 2009

Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle

scientific article published on 16 July 2008

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

scientific article published on 29 May 2012

Expression of Kir2.1 and Kir6.2 transgenes under the control of the α-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice

scientific article published on 22 September 2006

Expression of connexin 43, ion channels and Ca2+-handling proteins in rat pulmonary vein cardiomyocytes.

scientific article published on 03 October 2016

Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45

scientific article published on 02 August 2006

From the Purkinje fibres to the ventricle: One dimensional computer simulation for the healthy and failing heart

scientific article published on 01 January 2015

Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart.

scientific article

Funny current and sudden cardiac death

Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs

scientific article published in November 2021

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

scientific article published on 03 August 2017

Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system

scientific journal article

Imaging the heart: computer 3-dimensional anatomic models of the heart

scientific article

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

scientific article published on 24 January 2020

Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing

scientific article

Insights from echocardiography, magnetic resonance imaging, and microcomputed tomography relative to the mid-myocardial left ventricular echogenic zone.

scientific article published in October 2016

Ion channel transcript expression at the rabbit atrioventricular conduction axis.

scientific article

Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat.

scientific article published on June 2014

Letter by Anderson et al Regarding Article, “Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor”

scientific article published on 01 August 2008

Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat

scientific journal article

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study.

scientific article published in September 2017

Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy

scientific article published on February 2009

Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

scientific article published in June 2019

Molecular Basis of Arrhythmias Associated with the Cardiac Conduction System

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

scientific article

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

scientific article published on 16 March 2009

Molecular architecture of the human specialised atrioventricular conduction axis

scientific article published on 21 January 2011

Morphological characteristics of the sinus node on postmortem tissue.

scientific article published on 2 October 2015

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

scientific article

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

scientific article published on 15 November 2006

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

scientific article published on 21 February 2009

Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node

scientific article published on 24 March 2006

Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle

scientific article published on 17 April 2012

Reply to Matelot, Schnell, Kervio, Thillaye du Boullay, and Carre

scientific article

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

scientific article published on 14 July 2004

Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heart

scientific article published on 29 September 2006

Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node

scientific article published on 10 August 2007

STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE

Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.

scientific article

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

scientific article published on 09 July 2020

Simulation study of complex action potential conduction in atrioventricular node

scientific article published in January 2013

Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring

scientific article published on 13 August 2019

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart

scientific article published on 16 October 2003

Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function

scientific article

Structural and functional alterations in the atrioventricular node and atrioventricular ring tissue in ischaemia-induced heart failure.

scientific article

Structural and functional remodelling of the atrioventricular node with ageing in rats: the role of Hyperpolarization-activated cyclic-nucleotide gated and Ryanodine 2 channels

scientific article

Structural remodelling of the sinoatrial node in obese old rats

scientific article

Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues.

scientific article published on 20 April 2013

Structure-function relationship in the AV junction

scientific article published in October 2004

Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions

scientific article published on 01 September 2019

TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome

scientific article published on 13 October 2018

TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging

scientific article published on 14 April 2011

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.

scientific article published on 17 August 2017

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

scientific article published on 02 September 2018

The anatomy and physiology of the sinoatrial node--a contemporary review

scientific article

The anatomy of the cardiac conduction system

scientific article published on January 2009

The anatomy of the conduction system: implications for the clinical cardiologist

scientific article published on 15 December 2012

The extent of the specialized atrioventricular ring tissues

scientific article published on 21 January 2009

The sinoatrial node is still setting the pace 100 years after its discovery.

scientific article

Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours

scientific article

Viewpoint: Is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone?

scientific article published on 03 January 2013

Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI.

scientific article

What do we learn from double Cx40/Cx45-deficient mice about cardiac morphogenetic defects and conduction abnormalities?

scientific article published on 02 October 2006

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