List of works - Vsevolod Tkachuk

A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production ⬇️

scientific article published on October 1, 1992

Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration

scientific article published on 01 January 2002

Activation of phosphoinositide catabolism and DNA synthesis in vascular smooth muscle cells by LDL and positively charged proteins: evidence that effects of LDL are not specifically dependent on the polycationic nature of apo B

scientific article published on 01 September 1994

Activation of β-adrenergic receptors is required for elevated α1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.

scientific article

Adipose stromal cells stimulate angiogenesis via promoting progenitor cell differentiation, secretion of angiogenic factors, and enhancing vessel maturation.

scientific article published in August 2009

Adipose-derived mesenchymal stromal cells from aged patients with coronary artery disease keep mesenchymal stromal cell properties but exhibit characteristics of aging and have impaired angiogenic potential

scientific article

Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo

scientific article

An attempt to prevent senescence: a mitochondrial approach.

scientific article published on 29 December 2008

Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins.

scientific article published on 18 April 2013

Apparent activation of rabbit lung membrane adenylate cyclase by cytosolic proteins possessing adenylate kinase activity

scientific article published on 01 January 1991

Application of molecular modeling to urokinase inhibitors development.

scientific article published on 20 May 2014

Atherogenic effects of beta blockers on cells cultured from normal and atherosclerotic aorta

scientific article published on 01 May 1988

Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation

scientific article published on 01 December 1995

Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine.

scientific article

Calmodulin activates adenylate cyclase from rabbit heart plasma membranes

scientific article published on 01 August 1984

Cell adhesion molecule T-cadherin regulates vascular cell adhesion, phenotype and motility

scientific article

Cellular signalling by lipoproteins in cultured smooth muscle cells from spontaneously hypertensive rats

scientific article published on 01 May 1993

Characteristics and regulation of ganglioside-induced elevation of free cytoplasmic Ca2+ in human blood platelets

scientific article published on 01 July 1992

Characteristics of smooth muscle cell lipoprotein binding proteins (p105/p130) as T-cadherin and regulation by positive and negative growth regulators

scientific article published in May 1998

Combined transfer of human VEGF165 and HGF genes renders potent angiogenic effect in ischemic skeletal muscle

scientific article (publication date: 2012)

Contrasting effects of urokinase and tissue-type plasminogen activators on neointima formation and vessel remodelling after arterial injury

scientific article published in May 2004

Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil

scientific article published on 01 July 1984

Density- and proliferation status-dependent expression of T-cadherin, a novel lipoprotein-binding glycoprotein: a function in negative regulation of smooth muscle cell growth?

scientific article published on 01 August 1998

Diabetes mellitus, cachexia and obesity in heart failure: rationale and design of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)

scientific article

Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2

scientific article

Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma

scientific article published on 28 January 2020

Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle

scientific article published on 01 March 1992

Epinephrine potentiates activation of human platelets by low density lipoproteins

scientific article published on 01 September 1991

Evidence for the receptor-operated calcium channels in human platelet plasma membrane

scientific article published on 01 April 1987

Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.

scientific article

Functional expression of adrenoreceptors in mesenchymal stromal cells derived from the human adipose tissue

scientific article published on 16 May 2014

Glycosylphosphatidylinositol-Anchored Proteins as Regulators of Cortical Cytoskeleton

scientific article

Guanine-nucleotide-dependent inhibition of adenylate cyclase of rabbit heart by glucagon

scientific article published in July 1984

Guidance Receptors in the Nervous and Cardiovascular Systems.

scientific article

Heterotrimeric Gi protein is associated with the inositol 1,4,5-trisphosphate receptor complex and modulates calcium flux

scientific article published in May 1998

Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G-proteins

scientific article published on 01 December 1989

Hormonal sensitivity of adenylate cyclase incorporated in proteoliposomes

scientific article published on 01 January 1987

Hypersensitivity to isoproterenol in rabbit heart decreases guanine nucleotide effect on adenylate cyclase

scientific article published on 01 July 1979

Identification of 130 kDa cell surface LDL-binding protein from smooth muscle cells as a partially processed T-cadherin precursor

scientific article published on 01 January 1999

Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin

scientific article

In vitro neuronal induction of adipose-derived stem cells and their fate after transplantation into injured mouse brain.

scientific article published on January 2012

Inhibition by pertussis toxin of guanyl nucleotides exchange on transducin in bovine rod cell membranes.

scientific article

Insulin resistance and adipogenesis: Role of transcription and secreted factors ⬇️

scientific article published on January 1, 2013

Interaction of stable prostaglandin endoperoxide analogs U46619 and U44069 with human platelet membranes: coupling of receptors with high-affinity GTPase and adenylate cyclase.

scientific article

Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening.

scientific article

Interleukin-2- and phytohemagglutinin-activated proliferation of human T-lymphocytes is accompanied by stimulation of phosphoinositide turnover

scientific article published on 01 November 1989

Involvement of pertussis-toxin-sensitive G protein in muscarinic-receptor-mediated inhibition of K(+)-activated 4-nitrophenylphosphatase activity of cardiac sarcolemma

scientific article published on 01 November 1990

Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells

scientific article

Kinetic approach for evaluation of total antioxidant activity

scientific article published on 5 August 2009

LDL binds to surface-expressed human T-cadherin in transfected HEK293 cells and influences homophilic adhesive interactions

scientific article

LDL induces intracellular signalling and cell migration via atypical LDL-binding protein T-cadherin.

scientific article

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells.

scientific article

Molecular modeling as a new approach to the development of urokinase inhibitors

scientific article published on 17 March 2015

Non-viral transfer of BDNF and uPA stimulates peripheral nerve regeneration

scientific article published on 28 July 2015

Novel mechanism regulating endothelial permeability via T-cadherin-dependent VE-cadherin phosphorylation and clathrin-mediated endocytosis

scientific article

Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.

scientific article

Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator

scientific article published on 24 September 2008

Opposite effects of native and oxidized lipoproteins on the activity of secretory phospholipase A(2) group IIA.

scientific article

Phosphoinositide and calcium signalling responses in smooth muscle cells: comparison between lipoproteins, Ang II, and PDGF

scientific article published on 01 November 1992

Plasma urokinase antigen and C-reactive protein predict angina recurrence after coronary angioplasty

scientific article published on 22 September 2013

Plasminogen activator expression correlates with genetic differences in vascular remodeling.

scientific article

Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins

scientific article published on 01 October 1992

Polarisation of T-cadherin to the leading edge of migrating vascular cells in vitro: a function in vascular cell motility?

scientific article

Polyelectrolyte nanoparticles mediate vascular gene delivery

scientific article published in September 2004

Proteolytically inactive recombinant forms of urokinase suppress migration of endothelial cells

scientific article published on 01 April 2014

Receptor-operated channels in human platelets

scientific article published on 01 June 1989

Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator.

scientific article

Regulation of phosphoinositide turnover in endothelium from human pulmonary artery, aorta and umbilical vein. Antagonistic action on the beta-adrenoceptor coupled adenylate cyclase system.

scientific article

Separation and reconstitution of regulatory and catalytic components of heart adenylate cyclase.

scientific article

Signal-transducing GTP-binding proteins of mammalian heart and lungs

scientific article published on 01 February 1989

Stimulation of non-selective cation channels providing Ca2+ influx into platelets by platelet-activating factor and other aggregation inducers

scientific article published on 01 May 1991

Stretch affects phenotype and proliferation of vascular smooth muscle cells.

scientific article

Structural investigations of recombinant urokinase growth factor-like domain

scientific article published in May 2013

Synergistic potentiation of polyphosphoinositide breakdown by adenylate cyclase coupled receptors in human endothelial cells

scientific article published on 01 February 1989

T-Cadherin Expression in Melanoma Cells Stimulates Stromal Cell Recruitment and Invasion by Regulating the Expression of Chemokines, Integrins and Adhesion Molecules.

scientific article

T-cadherin GPI-anchor is insufficient for apical targeting in MDCK cells.

scientific article published on April 2005

T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability.

scientific article published on April 2009

T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells

scientific article

T-cadherin is located in the nucleus and centrosomes in endothelial cells.

scientific article

T-cadherin modulates endothelial barrier function.

scientific article published in April 2010

T-cadherin suppresses angiogenesis in vivo by inhibiting migration of endothelial cells

scientific article

The 65-kDa protein from pig heart. A new substrate for Clostridium botulinum ADP-ribosyltransferase (exoenzyme C3)

scientific article published on 01 November 1991

The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis

scientific article

The effect of low-density lipoproteins on mesenchymal stromal cells of adipose tissue

scientific article published on 01 November 2011

The role of secondary messengers in the regulation of lipid peroxidation in rat liver microsomes

scientific article published on 01 January 1988

Therapeutic potential of human mesenchymal stromal cells secreted components: a problem with standartization

scientific article published in November 2015

Transplantation of modified human adipose derived stromal cells expressing VEGF165 results in more efficient angiogenic response in ischemic skeletal muscle.

scientific article published on 6 June 2013

UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015

scientific article published on 14 May 2015

Unique genetic profile of hereditary hemochromatosis in Russians: high frequency of C282Y mutation in population, but not in patients

scientific article published in September 2005

Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching.

scientific article published on 3 June 2016

Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle.

scientific article published on 24 July 2007

Urokinase increases the content and activity of matrix metalloproteinases 2 and 9 during in vivo constrictive arterial remodeling

scientific article published on 01 March 2005

Urokinase induces ROS production in vascular smooth muscle cells

scientific article published on 01 September 2006

Urokinase induces matrix metalloproteinase-9/gelatinase B expression in THP-1 monocytes via ERK1/2 and cytosolic phospholipase A2 activation and eicosanoid production

scientific article published on 22 August 2006

Urokinase plasminogen activator augments cell proliferation and neointima formation in injured arteries via proteolytic mechanisms.

scientific article published in December 2001

Urokinase plasminogen activator induces human smooth muscle cell migration and proliferation via distinct receptor-dependent and proteolysis-dependent mechanisms

scientific article published on 01 May 1999

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor‐like domain ⬇️

scientific article published on September 8, 1997

Urokinase plasminogen activator system in humans with stable coronary artery disease

scientific article published on 01 April 1999

Urokinase receptor and tissue plasminogen activator as immediate-early genes in pentylenetetrazole-induced seizures in the mouse brain

scientific article published on 06 October 2019

Urokinase stimulates inflammatory response in damaged vascular wall during in vivo arterial remodeling

scientific article published on 01 January 2008

Urokinase upregulates matrix metalloproteinase-9 expression in THP-1 monocytes via gene transcription and protein synthesis

scientific article

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin.

scientific article

Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression

scientific article published on 04 May 2016

miR-92a regulates angiogenic activity of adipose-derived mesenchymal stromal cells.

scientific article published on 15 October 2015

List of works by Vsevolod Tkachuk

A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production ⬇️

Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration

Activation of phosphoinositide catabolism and DNA synthesis in vascular smooth muscle cells by LDL and positively charged proteins: evidence that effects of LDL are not specifically dependent on the polycationic nature of apo B

Activation of β-adrenergic receptors is required for elevated α1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.

Adipose stromal cells stimulate angiogenesis via promoting progenitor cell differentiation, secretion of angiogenic factors, and enhancing vessel maturation.

Adipose-derived mesenchymal stromal cells from aged patients with coronary artery disease keep mesenchymal stromal cell properties but exhibit characteristics of aging and have impaired angiogenic potential

Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo

An attempt to prevent senescence: a mitochondrial approach.

Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins.

Apparent activation of rabbit lung membrane adenylate cyclase by cytosolic proteins possessing adenylate kinase activity

Application of molecular modeling to urokinase inhibitors development.

Atherogenic effects of beta blockers on cells cultured from normal and atherosclerotic aorta

Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation

Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine.

Calmodulin activates adenylate cyclase from rabbit heart plasma membranes

Cell adhesion molecule T-cadherin regulates vascular cell adhesion, phenotype and motility

Cellular signalling by lipoproteins in cultured smooth muscle cells from spontaneously hypertensive rats

Characteristics and regulation of ganglioside-induced elevation of free cytoplasmic Ca2+ in human blood platelets

Characteristics of smooth muscle cell lipoprotein binding proteins (p105/p130) as T-cadherin and regulation by positive and negative growth regulators

Combined transfer of human VEGF165 and HGF genes renders potent angiogenic effect in ischemic skeletal muscle

Contrasting effects of urokinase and tissue-type plasminogen activators on neointima formation and vessel remodelling after arterial injury

Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil

Density- and proliferation status-dependent expression of T-cadherin, a novel lipoprotein-binding glycoprotein: a function in negative regulation of smooth muscle cell growth?

Diabetes mellitus, cachexia and obesity in heart failure: rationale and design of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)

Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2

Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma

Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle

Epinephrine potentiates activation of human platelets by low density lipoproteins

Evidence for the receptor-operated calcium channels in human platelet plasma membrane

Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.

Functional expression of adrenoreceptors in mesenchymal stromal cells derived from the human adipose tissue

Glycosylphosphatidylinositol-Anchored Proteins as Regulators of Cortical Cytoskeleton

Guanine-nucleotide-dependent inhibition of adenylate cyclase of rabbit heart by glucagon

Guidance Receptors in the Nervous and Cardiovascular Systems.

Heterotrimeric Gi protein is associated with the inositol 1,4,5-trisphosphate receptor complex and modulates calcium flux

Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G-proteins

Hormonal sensitivity of adenylate cyclase incorporated in proteoliposomes

Hypersensitivity to isoproterenol in rabbit heart decreases guanine nucleotide effect on adenylate cyclase

Identification of 130 kDa cell surface LDL-binding protein from smooth muscle cells as a partially processed T-cadherin precursor

Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin

In vitro neuronal induction of adipose-derived stem cells and their fate after transplantation into injured mouse brain.

Inhibition by pertussis toxin of guanyl nucleotides exchange on transducin in bovine rod cell membranes.

Insulin resistance and adipogenesis: Role of transcription and secreted factors ⬇️

Interaction of stable prostaglandin endoperoxide analogs U46619 and U44069 with human platelet membranes: coupling of receptors with high-affinity GTPase and adenylate cyclase.

Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening.

Interleukin-2- and phytohemagglutinin-activated proliferation of human T-lymphocytes is accompanied by stimulation of phosphoinositide turnover

Involvement of pertussis-toxin-sensitive G protein in muscarinic-receptor-mediated inhibition of K(+)-activated 4-nitrophenylphosphatase activity of cardiac sarcolemma

Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells

Kinetic approach for evaluation of total antioxidant activity

LDL binds to surface-expressed human T-cadherin in transfected HEK293 cells and influences homophilic adhesive interactions

LDL induces intracellular signalling and cell migration via atypical LDL-binding protein T-cadherin.

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells.

Molecular modeling as a new approach to the development of urokinase inhibitors

Non-viral transfer of BDNF and uPA stimulates peripheral nerve regeneration

Novel mechanism regulating endothelial permeability via T-cadherin-dependent VE-cadherin phosphorylation and clathrin-mediated endocytosis

Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.

Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator

Opposite effects of native and oxidized lipoproteins on the activity of secretory phospholipase A(2) group IIA.

Phosphoinositide and calcium signalling responses in smooth muscle cells: comparison between lipoproteins, Ang II, and PDGF

Plasma urokinase antigen and C-reactive protein predict angina recurrence after coronary angioplasty

Plasminogen activator expression correlates with genetic differences in vascular remodeling.

Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins

Polarisation of T-cadherin to the leading edge of migrating vascular cells in vitro: a function in vascular cell motility?

Polyelectrolyte nanoparticles mediate vascular gene delivery

Proteolytically inactive recombinant forms of urokinase suppress migration of endothelial cells

Receptor-operated channels in human platelets

Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator.

Regulation of phosphoinositide turnover in endothelium from human pulmonary artery, aorta and umbilical vein. Antagonistic action on the beta-adrenoceptor coupled adenylate cyclase system.

Separation and reconstitution of regulatory and catalytic components of heart adenylate cyclase.

Signal-transducing GTP-binding proteins of mammalian heart and lungs

Stimulation of non-selective cation channels providing Ca2+ influx into platelets by platelet-activating factor and other aggregation inducers

Stretch affects phenotype and proliferation of vascular smooth muscle cells.

Structural investigations of recombinant urokinase growth factor-like domain

Synergistic potentiation of polyphosphoinositide breakdown by adenylate cyclase coupled receptors in human endothelial cells

T-Cadherin Expression in Melanoma Cells Stimulates Stromal Cell Recruitment and Invasion by Regulating the Expression of Chemokines, Integrins and Adhesion Molecules.

T-cadherin GPI-anchor is insufficient for apical targeting in MDCK cells.

T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability.

T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells

T-cadherin is located in the nucleus and centrosomes in endothelial cells.