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List of works by Laszlo Prokai

"All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect

scientific article published on January 2012

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

scientific article published on 05 June 2018

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

scientific article published on 27 January 2020

17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma.

scientific article published on 23 July 2013

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma

scientific article

A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy

scientific article published on 19 November 2019

A Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos

scientific article

A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease

scientific article

A component of Premarin® enhances multiple cognitive functions and influences nicotinic receptor expression ⬇️

scientific article published on September 19, 2010

A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents

scientific article published on 01 March 2005

A strategy for delivering peptides into the central nervous system by sequential metabolism

scientific article

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

scientific article published on 25 November 2017

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.

scientific article

Antifungal unsaturated cyclic Mannich ketones and amino alcohols: study of mechanism of action.

scientific article

Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry.

scientific article

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

scientific article published on 18 July 2019

Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

scientific article published on 10 June 2020

Brain-targeted chemical delivery of [Leu2, Pip3]-TRH: synthesis and biological evaluation

scientific article published in May 2000

Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design

scientific article published in November 1996

Capture of the volatile carbonyl metabolite of flecainide on 2,4-dinitrophenylhydrazine cartridge for quantitation by stable-isotope dilution mass spectrometry coupled with chromatography

scientific article published on 31 January 2012

Cardiovascular effects of neuropeptide FF antagonists

scientific article published on 21 February 2006

Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium.

scientific article published in November 2004

Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation

scientific article

Chip-based nanoelectrospray ionization with Fourier transform mass spectrometric detection to screen for local anesthetics intended to mask limb sore in walking horses

scientific article published in March 2015

Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study

scientific article published on February 2016

Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time ⬇️

scientific article published on May 12, 2011

Combinatorial lead optimization of a neuropeptide FF antagonist.

scientific article

Comparative Proteomics Analysis Reveals Unique Early Signaling Response of <i>Saccharomyces cerevisiae</i> to Oxidants with Different Mechanism of Action

scientific article published on 26 December 2020

Comparison of estrogen-derived ortho-quinone and para-quinol concerning induction of oxidative stress.

scientific article published on 17 May 2007

Conversion of 3-nitrotyrosine to 3-aminotyrosine residues facilitates mapping of tyrosine nitration in proteins by electrospray ionization-tandem mass spectrometry using electron capture dissociation

scientific article published in December 2012

Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ERbeta in mitochondria".

scientific article

Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections

scientific article published on 11 July 2016

De novo sequencing of a 21-kDa cytochrome c4 from Thiocapsa roseopersicina by nanoelectrospray ionization ion-trap and Fourier-transform ion-cyclotron resonance mass spectrometry.

scientific article published in December 2007

Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs

scientific article published on January 2013

Design, synthesis, and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues.

scientific article

Desorption chemical ionization, thermospray, and fast atom bombardment mass spectrometry of dihydropyridine in equilibrium with pyridinium salt-type redox systems

scientific article published on 01 August 1989

Detection and identification of 4-hydroxy-2-nonenal Schiff-base adducts along with products of Michael addition using data-dependent neutral loss-driven MS3 acquisition: method evaluation through an in vitro study on cytochrome c oxidase modificatio

scientific article

Determination of clodronate content in liposomal formulation by capillary zone electrophoresis

scientific article published in April 2003

Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

scientific article published on 16 January 2016

Drug identification problems in two suicides with neuromuscular blocking agents.

scientific article published in December 1989

Effect of chronic morphine exposure on the synaptic plasma-membrane subproteome of rats: a quantitative protein profiling study based on isotope-coded affinity tags and liquid chromatography/mass spectrometry

scientific article published in February 2005

Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

scientific article published on 31 March 2017

Electrospray ionization mass spectrometric and liquid chromatographic-mass spectrometric studies on the metabolism of synthetic dynorphin A peptides in brain tissue in vitro and in vivo

scientific article published in March 1998

Electrospray ionization mass spectrometric study of encapsulation of amino acids by cyclodextrins

scientific article published on 01 September 1995

Enhancement of phosphoprotein analysis using a fluorescent affinity tag and mass spectrometry

scientific article published in January 2005

Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics.

scientific article published on 16 August 2008

Fourier transform ion cyclotron resonance mass spectrometry of covalent adducts of proteins and 4-hydroxy-2-nonenal, a reactive end-product of lipid peroxidation

scientific article published on 6 September 2007

Gel permeation chromatography coupled to fourier transform mass spectrometry for polymer characterization

scientific article published on 01 November 1999

Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.

scientific article published in April 2007

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration

scientific article

Identification of carbonylation sites in apomyoglobin after exposure to 4-hydroxy-2-nonenal by solid-phase enrichment and liquid chromatography-electrospray ionization tandem mass spectrometry.

scientific article published in April 2010

Identification of synaptic metabolites of dynorphin A (1-8) by electrospray ionization and tandem mass spectrometry

scientific article published in January 1998

Immobilized artificial membrane chromatography coupled with atmospheric pressure ionization mass spectrometry

scientific article

In vitro and in vivo study of water-soluble prodrugs of dexanabinol

scientific article published on 01 November 1999

Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell.

scientific article published on 6 October 2007

Investigation of cytolysin variants by peptide mapping: enhanced protein characterization using complementary ionization and mass spectrometric techniques.

scientific article

Isotope-coded dimethyl tagging for differential quantification of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation.

scientific article

Label-free LC-MS/MS identification of phosphatidylglycerol-regulated proteins in Synechocystis sp. PCC6803.

scientific article published on May 2014

Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.

scientific article

Leucine enkephalin-tyrosinase reaction products--identification and biological activity

scientific article published in May 1994

Mannich Ketones as Possible Antimycobacterial Agents.

scientific article published on 28 July 2017

Mass spectrometric analysis of carisoprodol and meprobamate in rat brain microdialysates

scientific article published in October 2016

Mass spectrometry-based survey of age-associated protein carbonylation in rat brain mitochondria

scientific article

Measurement of Acetylcholine in Rat Brain Microdialysates by LC - Isotope Dilution Tandem MS.

scientific article published on October 2008

Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats.

scientific article

Metabolism of dynorphins by peptidases of pulmonary artery endothelial cells

scientific article published in January 2002

Metabolism-based brain-targeting system for a thyrotropin-releasing hormone analogue

scientific article published in November 1999

Micellar aggregation and membrane partitioning of bile salts, fatty acids, sodium dodecyl sulfate, and sugar-conjugated fatty acids: correlation with hemolytic potency and implications for drug delivery

scientific article published in May 2004

Microcolumn size-exclusion chromatography coupled with electrospray ionization mass spectrometry

scientific article published in March 1999

Misidentification of nitrated peptides: comments on Hong, S.J., Gokulrangan, G., Schöneich, C., 2007. Proteomic analysis of age-dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry

scientific article published on 11 March 2009

Mitochondria play a central role in estrogen-induced neuroprotection.

scientific article

Mitochondrial localization of estrogen receptor beta

scientific article

Modifying peptide properties by prodrug design for enhanced transport into the CNS.

scientific article published on January 2003

Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu2]TRH and its chemical brain-targeting system.

scientific article published in October 2002

Non-Feminizing Estrogens Do Not Exhibit Antidepressant-like Activity

Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells.

scientific article

Ocular delivery of the beta-adrenergic antagonist alprenolol by sequential bioactivation of its methoxime analogue.

scientific article

Ocular-specific chemical delivery systems of betaxolol for safe local treatment of glaucoma.

scientific article published on August 1997

Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs

scientific article published on 01 October 1997

Peptide drug delivery into the central nervous system.

scientific article

Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress.

scientific article published on 20 April 2009

Polyamine-vectored iron chelators: the role of charge.

scientific article published on June 2005

Preoperative endovascular brain mapping for intraoperative volumetric image guidance: preliminary concept and feasibility in animal models.

scientific article

Prodrug design for brain delivery of small- and medium-sized neuropeptides

scientific article published in January 2011

Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.

scientific article published in March 2003

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria.

scientific article

Proteomic analysis of mouse brain microsomes: identification and bioinformatic characterization of endoplasmic reticulum proteins in the mammalian central nervous system

scientific article published on 14 February 2008

Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression

scientific article (publication date: 2013)

Proteomic analysis of the synaptic plasma membrane fraction isolated from rat forebrain.

scientific article

Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation.

scientific article published on 11 January 2013

Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

scientific article

Quinol-based metabolic cycle for estrogens in rat liver microsomes.

scientific article published in June 2003

Rapid characterization of covalent modifications to rat brain mitochondrial proteins after ex vivo exposure to 4-hydroxy-2-nonenal by liquid chromatography-tandem mass spectrometry using data-dependent and neutral loss-driven MS3 acquisition

scientific article

Rapid label-free identification of estrogen-induced differential protein expression in vivo from mouse brain and uterine tissue.

scientific article published on August 2009

Relative quantitation of protein nitration by liquid chromatography-mass spectrometry using isotope-coded dimethyl labeling and chemoprecipitation.

scientific article

Remodeling of phosphatidylglycerol in Synechocystis PCC6803.

scientific article published on 24 October 2009

Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug

scientific article published on 16 May 2020

RimJ-mediated context-dependent N-terminal acetylation of the recombinant Z-domain protein in Escherichia coli.

scientific article

Selective N-terminal fluorescent labeling of proteins using 4-chloro-7-nitrobenzofurazan: a method to distinguish protein N-terminal acetylation

scientific article published on 04 June 2012

Selective chemoprecipitation and subsequent release of tagged species for the analysis of nitropeptides by liquid chromatography-tandem mass spectrometry

scientific article

Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

scientific article

Sequential bioactivation of methoxime analogs of beta-adrenergic antagonists in the eye

scientific article published on 01 January 1995

Simultaneous Measurement of 17β-Estradiol, 17α-Estradiol and Estrone by GC-Isotope Dilution MS/MS.

scientific article

Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation

scientific article published on 01 July 1990

Strategies to target kyotorphin analogues to the brain

scientific article published in September 1998

Synthesis and biological evaluation of 17beta-alkoxyestra-1,3, 5(10)-trienes as potential neuroprotectants against oxidative stress.

scientific article

Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

scientific article published on 23 January 2017

Targeting drugs to the brain by redox chemical delivery systems.

scientific article

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

scientific article

Tissue penetration and antimicrobial activity of standard- and high-dose trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection

scientific article published on 19 July 2013

To tag or not to tag: A comparative evaluation of immunoaffinity-labeling and tandem mass spectrometry for the identification and localization of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation ⬇️

scientific article published on July 30, 2011

Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats.

scientific article

Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

scientific article

[99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

scientific article published on 01 January 2019

[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

scientific article

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