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List of works by Ralf J. Ludwig

A recombinant fusion protein derived from dog hookworm inhibits autoantibody-induced dermal-epidermal separation ex vivo

scientific article

ADF Winter School-An exciting concept of the Arbeitsgemeinschaft Dermatologische Forschung to connect young scientists and clinician scientists in Dermatology at the top of Germany

scientific article published on 3 November 2016

Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid

scientific article

Activated CD4+ T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation.

scientific article published on 4 November 2013

Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules

scientific article

Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases

scientific article published on 29 May 2015

Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid

scientific article published on 13 May 2017

Animal models for autoimmune bullous dermatoses.

scientific article published on 21 August 2009

Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses.

scientific article published on January 2015

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.

scientific article

Application, tolerance and safety of fondaparinux therapy in a German hospital: a prospective single-centre experience

scientific article

Association between TH2 Cytokine Gene Polymorphisms and Risk of Bullous Pemphigoid

scientific article published on 13 October 2020

Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3.

scientific article published on 22 March 2018

Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters

scientific article published on 17 February 2015

Autoantibody-induced intestinal inflammation and weight loss in experimental epidermolysis bullosa acquisita

scientific article published on 7 March 2011

B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita

scientific article published on 19 August 2013

Biodiversity of mycobial communities in health and onychomycosis

scientific article published on 25 May 2022

Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo

scientific article published on 07 March 2014

CCL3/MIP1α represents a biomarker but not a mandatory cytokine for disease development in experimental epidermolysis bullosa acquisita

scientific article published on 30 June 2017

Calcitriol Treatment Ameliorates Inflammation and Blistering in Mouse Models of Epidermolysis Bullosa Acquisita.

scientific article

Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules

scientific article published on 20 March 2015

Chronic dermatophytosis in lamellar ichthyosis: relevance of a T-helper 2-type immune response to Trichophyton rubrum

scientific article published on 01 September 2001

Chronic venous insufficiency - a potential trigger for localized scleroderma

scientific article published on 01 January 2006

Clearance rates of circulating and tissue-bound autoantibodies to type VII collagen in experimental epidermolysis bullosa acquisita

scientific article published on 04 March 2010

Clinical features and diagnosis of epidermolysis bullosa acquisita

scientific article

Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita

scientific article published on 15 July 2013

Co-occurrence of autoantibodies in healthy blood donors

scientific article published on July 2014

Complement-fixing anti-type VII collagen antibodies are induced in Th1-polarized lymph nodes of epidermolysis bullosa acquisita-susceptible mice

scientific article published on 03 October 2011

Complicated mycosis fungoides mimicking facial erysipelas

scientific article published on 01 June 2005

Computer-aided analysis of cell interactions under dynamic flow conditions.

scientific article published on 22 October 2008

Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita.

scientific article published on 12 March 2015

Constitutive and functionally relevant expression of JAM-C on platelets

scientific article published on 2 February 2010

Cytokines in autoimmune bullous skin diseases. Epiphenomena or contribution to pathogenesis?

scientific article published on 01 August 2009

Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita

scientific article

Development of a simple enzyme-linked immunosorbent assay for the detection of autoantibodies in anti-p200 pemphigoid

scientific article

Dimethylfumarate Impairs Neutrophil Functions

scientific article published in January 2016

Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expression

scientific article published on 02 August 2007

Diminished lymphocyte adhesion and alleviation of allergic responses by small-molecule- or antibody-mediated inhibition of L-selectin functions

scientific article published on 10 August 2006

Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions

scientific article published on 01 April 2007

Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita.

scientific article published on 3 February 2016

Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease

scientific article published on 16 February 2016

Drug Discovery for Pemphigoid Diseases

scientific article published on 20 February 2019

Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation

scientific article

Emerging treatments for pemphigoid diseases.

scientific article published on 04 July 2013

Enchondroma: a benign osseous lesion with high F-18 FDG uptake.

scientific article published in October 2002

Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis.

scientific article published on April 2004

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

scientific article published on 30 May 2012

Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinoma

scientific article published on 01 July 2005

Epidermal Damage Induces Th1 Polarization and Defines the Site of Inflammation in Murine Epidermolysis Bullosa Acquisita

scientific article published on 11 February 2020

Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options.

scientific article

Epidermolysis Bullosa Acquisita: The 2019 Update

scientific article published on 01 January 2018

Evidence for a contributory role of a xenogeneic immune response in experimental epidermolysis bullosa acquisita.

scientific article published on 8 September 2017

Fcγ receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid

scientific article published in August 2014

FcγRIIA and FcγRIIIB are required for autoantibody-induced tissue damage in experimental human models of bullous pemphigoid

scientific article published on 19 August 2010

Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering

scientific article published on 05 February 2014

From bedside to bench--reverse translational medicine. Scientific lessons from revertant mosaicism in 'knockout' humans

scientific article published on 21 July 2014

From epidemiology and genetics to diagnostics, outcome measures, and novel treatments in autoimmune bullous diseases.

scientific article

GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita

scientific article published on 11 December 2013

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

scientific article published on 10 September 2019

Generation of antibodies of distinct subclasses and specificity is linked to H2s in an active mouse model of epidermolysis bullosa acquisita.

scientific article

Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease

scientific article published in August 2013

Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury

article

Genetic variant association of PTPN22, CTLA4, IL2RA, as well as HLA frequencies in susceptibility to alopecia areata

scientific article published on 06 July 2018

Heat shock protein 90 is required for ex vivo neutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita

scientific article published on 25 March 2015

Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets

scientific article published on 13 April 2011

Heparin-induced skin lesions

scientific article

Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome).

scientific article published in May 2003

High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy

scientific article

How shingles can be beached

scientific article published on 01 October 2007

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration

scientific article published on December 2015

Identification of Quantitative Trait Loci in Experimental Epidermolysis Bullosa Acquisita

scientific article published on 02 February 2012

Identification of novel therapeutic targets for blocking acantholysis in pemphigus

scientific article published on 19 August 2020

Immune mechanism-targeted treatment of experimental epidermolysis bullosa acquisita.

scientific article published on 15 October 2015

Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses

article

Improvement of treatment-refractory atopic dermatitis by immunoadsorption: a pilot study

scientific article published on 20 October 2010

In Vivo Expansion of Endogenous Regulatory T Cell Populations Induces Long-Term Suppression of Contact Hypersensitivity.

scientific article

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury.

scientific article published on 11 August 2016

In vivo microscopy of murine islets of Langerhans: increased adhesion of transferred lymphocytes to islets depends on macrophage-derived cytokines in a model of organ-specific insulitis

scientific article published on 01 September 1999

Incidence and causes of heparin-induced skin lesions

scientific article

Increased TREM-1 expression in inflamed skin has no functional impact on the pathogenesis of cutaneous disorders

scientific article published on 30 May 2017

Intolerance of fondaparinux in a patient allergic to heparins

scientific article

Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin

scientific article published in October 2009

Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation

scientific article

Leprosy in a pregnant woman

scientific article published on 01 February 2007

Low allergenic potential with fondaparinux: results of a prospective investigation

scientific article

Low incidence of heparin-induced skin lesions in orthopedic surgery patients with low-molecular-weight heparins

scientific article published on 05 June 2018

Lymphocyte trafficking to inflamed skin--molecular mechanisms and implications for therapeutic target molecules

scientific article

Management of cutaneous type IV hypersensitivity reactions induced by heparin.

scientific article

Mapping of B cell epitopes on desmoglein 3 in pemphigus vulgaris patients by the use of overlapping peptides.

scientific article published on 30 December 2011

Matrix meets inflammation and DNA repair: Meeting report of the third ADF Round Table

scientific article published on 3 February 2017

Mechanisms of Autoantibody-Induced Pathology.

scientific article

Meeting Report of the Pathogenesis of Pemphigus and Pemphigoid Meeting in Munich, September 2016.

scientific article published on 5 April 2017

Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells

scientific article published on 08 August 2006

Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice.

scientific article

Methylprednisolone blocks autoantibody-induced tissue damage in experimental models of bullous pemphigoid and epidermolysis bullosa acquisita through inhibition of neutrophil activation

scientific article published on 28 February 2013

Model systems duplicating epidermolysis bullosa acquisita: a methodological review

scientific article published on September 19, 2011

Molecular weight determines the frequency of delayed type hypersensitivity reactions to heparin and synthetic oligosaccharides

scientific article published on 01 December 2005

Myeloid-related proteins-8 and -14 are expressed but dispensable in the pathogenesis of experimental epidermolysis bullosa acquisita and bullous pemphigoid

scientific article published on 02 December 2015

Nadroparin carries a potentially high risk of inducing cutaneous delayed-type hypersensitivity responses

scientific article

Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re-epithelialization in human skin.

scientific article published on 23 September 2017

Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease

scientific article published on 01 December 2002

Narrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasis

scientific article published in May 2004

New insight into the transport mechanism of hydrated hydroxide ions in water

scientific article published on 01 January 2003

New insights into pemphigoid diseases.

scientific article published on 21 November 2017

Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo.

scientific article published on 30 November 2006

Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita

scientific article published on 26 September 2011

Overlapping and Distinct FAS/FASLG Gene Polymorphisms in Alopecia Areata in an Iranian Population

scientific article published on 19 November 2019

P-selectin: a common therapeutic target for cardiovascular disorders, inflammation and tumour metastasis

scientific article published on August 2007

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

scientific article published on 4 July 2016

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

scientific article

PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contact hypersensitivity responses through inhibition of L- and P-selectin functions.

scientific article published on 4 December 2008

Pathogenesis of Epidermolysis Bullosa Acquisita ⬇️

scientific article published on July 1, 2011

Pathogenicity of IgG subclass autoantibodies to type VII collagen: induction of dermal-epidermal separation

scientific article published on 30 November 2009

Pathogenicity of autoantibodies in anti-p200 pemphigoid.

scientific article

Persistence of peri-neural granulomas after successful treatment of leprosy

scientific article published in November 2007

Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita

scientific article

Perspective From the 5th International Pemphigus and Pemphigoid Foundation Scientific Conference

scientific article published on 08 November 2018

Platelet P-selectin reflects a state of cutaneous inflammation: possible application to monitor treatment efficacy in psoriasis

scientific article published on 01 August 2010

Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity

scientific article published on 7 January 2010

Prevalence of pemphigus and pemphigoid autoantibodies in the general population

scientific article

Psoriasis and risk of myocardial infarction.

scientific article published in January 2007

Psoriasis patients show signs of insulin resistance

scientific article published on 4 October 2007

Psoriasis: a possible risk factor for development of coronary artery calcification

scientific article

Quantification of the relationship between pyoderma gangrenosum and Crohn's disease: a population-based case-control study

scientific article published on 07 July 2020

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

scientific article

Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction

scientific article

Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita

scientific article published on 20 October 2014

Reduced skin blistering in experimental epidermolysis bullosa acquisita after anti-TNF treatment

scientific article published on 20 December 2016

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases

scientific article

Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease

scientific article published on 26 April 2018

Repetitive immunization breaks tolerance to type XVII collagen and leads to bullous pemphigoid in mice

scientific article published on 24 June 2011

Rituximab for treatment-refractory pemphigus and pemphigoid: A case series of 17 patients

scientific article published on 01 September 2011

Sensitive and specific assays for routine serological diagnosis of epidermolysis bullosa acquisita

scientific article published on 16 February 2012

Serum Levels of Autoantibodies Against Extracellular Antigens and Neutrophil Granule Proteins Increase in Patients with COPD Compared to Non-COPD Smokers

scientific article published on 29 January 2020

Shear stress-mediated adhesion of acute myeloid leukemia and KG-1 cells to endothelial cells involves functional P-selectin

scientific article

Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita.

scientific article published on 7 March 2017

Skin microbiota-associated inflammation precedes autoantibody induced tissue damage in experimental epidermolysis bullosa acquisita.

scientific article published on September 2015

Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration

scientific article published on November 2002

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

scientific article published on 16 March 2018

Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities.

scientific article published on September 2006

Successful pregnancy outcome under prolonged ustekinumab treatment in a patient with Crohn's disease and paradoxical psoriasis

scientific article published on 11 November 2015

T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita

scientific article published on 5 December 2016

TNF-α -308G/A gene polymorphism in bullous pemphigoid and alopecia areata

scientific article published on 01 January 2018

The Anti-C1s Antibody TNT003 Prevents Complement Activation in the Skin Induced by Bullous Pemphigoid Autoantibodies.

scientific article published on 9 September 2017

The Growing Incidence of Bullous Pemphigoid: Overview and Potential Explanations

scientific article published on 20 August 2018

The Leukotriene B4 and its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita

scientific article published on 17 January 2017

The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivo

scientific article published on 01 March 2006

The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™-induced psoriasiform dermatitis

scientific article published on 20 December 2016

The immune system of mouse vibrissae follicles: cellular composition and indications of immune privilege

scientific article published in September 2013

The influence of heparin's molecular weight and the incidence of delayed type hypersensitivity reactions revisited; in response to Grims et al., Br J Dermatol 2007; 157:514-17.

scientific article

The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacity

scientific article published on 13 May 2006

The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita

scientific article published on 15 June 2015

The risk for cross-reactions after a cutaneous delayed-type hypersensitivity reaction to heparin preparations is independent of their molecular weight: a systematic review ⬇️

scientific article published on June 1, 2011

The selective cyclooxygenase-2 inhibitor rofecoxib may improve the treatment of chronic idiopathic urticaria.

scientific article published in March 2003

Therapeutic Effect of a Novel Phosphatidylinositol-3-Kinase δ Inhibitor in Experimental Epidermolysis Bullosa Acquisita

scientific article published on 12 July 2018

Therapeutic use of heparin beyond anticoagulation

scientific article

Tolerance of Fondaparinux in Immediate-type Hypersensitivity to Heparins

scientific article published on 11 July 2015

Tolerance of fondaparinux in a patient allergic to heparins and other glycosaminoglycans

scientific article published in September 2003

Tolerance of fondaparinux in patients with generalized contact dermatitis to heparin

scientific article published in March 2008

Topical 5-fluorouracil in Darier disease

scientific article published on 10 April 2008

Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation.

scientific article published on 19 September 2016

Topically applied flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita

scientific article published on 06 December 2012

Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice

scientific article published on 06 March 2020

Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV)

scientific article published on 24 August 2020

Visualization of autoantibodies and neutrophils in vivo identifies novel checkpoints in autoantibody-induced tissue injury

scientific article published on 11 March 2020

Vitamin D status in patients with bullous pemphigoid

scientific article published on 17 December 2012

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.

scientific article published on 15 February 2018

[New information about fumaric acid esters (Fumaderm): results of a workshop of experts]

scientific article published on 01 September 2011

[New insights into fumaric acid esters (Fumaderm ®):results of the 2nd Expert Workshops]

scientific article published on 01 December 2012

ptRNApred: computational identification and classification of post-transcriptional RNA

scientific article published on 10 October 2014

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