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List of works by Marileila Varella-Garcia

A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.

scientific article

A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer ⬇️

scientific article published on February 1, 2012

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins ⬇️

scientific article published on 04 April 2013

A randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer

scientific article

ALDH+ tumor‐initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ‐secretase inhibitor and irinotecan in colorectal cancer ⬇️

scientific article published on March 28, 2012

ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer.

scientific article

Abnormalities of the TITF-1 Lineage-Specific Oncogene in NSCLC: Implications in Lung Cancer Pathogenesis and Prognosis ⬇️

scientific article published on January 21, 2011

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

scientific article

Activation of RAS family members confers resistance to ROS1 targeting drugs.

scientific article

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

scientific article published on 04 September 2012

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines

scientific article

An Activating KIT Mutation Induces Crizotinib Resistance in ROS1-Positive Lung Cancer

scientific article published on 8 April 2016

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101

scientific article

Anaplastic Lymphoma Kinase Gene Rearrangements in Non-small Cell Lung Cancer are Associated with Prolonged Progression-Free Survival on Pemetrexed ⬇️

scientific article published on April 1, 2011

Anaplastic lymphoma kinase (ALK) gene alteration in signet ring cell carcinoma of the gastrointestinal tract.

scientific article

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

scientific article

Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: results From the Prostate Cancer Prevention Trial.

scientific article

Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels

scientific article published on December 2006

Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions

scientific article published on 17 December 2013

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.

scientific article

Atypical negative ALK break-apart FISH harboring a crizotinib-responsive ALK rearrangement in non-small-cell lung cancer

scientific article published on March 2014

Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.

scientific article published on 22 September 2017

Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy

scientific article published on June 2006

Biomarker Testing for Personalized Therapy in Lung Cancer in Low- and Middle-Income Countries

scientific article

Biomarkers are here to stay for clinical research and standard care

scientific article published on 01 August 2010

Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study

scientific article

Chromosomal abnormalities in non-small cell lung carcinomas and in bronchial epithelia of high-risk smokers detected by multi-target interphase fluorescence in situ hybridization

scientific article published in May 2003

Chromosomal and genomic changes in lung cancer

scientific article

Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer

scientific article

Chromosomal imbalances are uncommon in chagasic megaesophagus

scientific article

Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer

scientific article published on 17 June 2017

Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium

scientific article

Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.

scientific article published on May 2012

Comparison of Molecular Testing Modalities for Detection of ROS1 Rearrangements in a Cohort of Positive Patient Samples

scientific article published on 20 June 2018

Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer

scientific article published in April 2008

Correlations between the percentage of tumor cells showing an anaplastic lymphoma kinase (ALK) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization–positive nonsmall cell lung cancer ⬇️

scientific article published on January 26, 2012

Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification

article by Brian L. Rothschild et al published 15 August 2006 in Cancer Research

Crizotinib in ROS1-rearranged non-small-cell lung cancer.

scientific article

D4-02: Aneusomy by FISH analysis and histology as predictors of invasive lung cancer in bronchial biopsies from high risk subjects

scientific article

De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific ⬇️

scientific article published on August 2, 2010

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies.

scientific article

Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.

scientific article

Diagnostic assays for identification of anaplastic lymphoma kinase‐positive non–small cell lung cancer ⬇️

scientific article published on December 20, 2012

Diphtheria Toxin–Epidermal Growth Factor Fusion Protein DAB389EGF for the Treatment of Bladder Cancer ⬇️

scientific article published on November 21, 2012

Do More With Less: Tips and Techniques for Maximizing Small Biopsy and Cytology Specimens for Molecular and Ancillary Testing: The University of Colorado Experience

scientific article published on 9 September 2016

Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with vandetanib sensitizes bladder cancer cells to cisplatin in a dose- and sequence-dependent manner.

scientific article

EGFR Gene Copy Number by FISH May Predict Outcome of Necitumumab in Squamous Lung Carcinomas: Analysis from the SQUIRE Study

scientific article published on 17 November 2017

EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases

scientific article published on 20 April 2017

EGFR and HER2 Gene Copy Number and Response to First-Line Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer (NSCLC)

article

EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort

scientific article

EGFR-mutant lung adenocarcinoma in a patient with Li-Fraumeni syndrome

article

Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

scientific article

Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy

scientific article

Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies

scientific article

Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma

scientific article published on 19 October 2004

Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer

scientific article

Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

scientific article

Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer

scientific article

Erratum to: Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy

scientific article published on 8 April 2016

Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer

scientific article published on July 2015

Finding ALK-Positive Lung Cancer: What Are We Really Looking for? ⬇️

scientific article published on 01 March 2011

First-generation epidermal growth factor receptor inhibitors in non-small cell lung cancer: clinical impact of the epidermal growth factor receptor fluorescence in situ hybridization assay

scientific article published on June 2008

Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer

scientific article

Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study

scientific article

Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer ⬇️

scientific article published on 03 August 2010

Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer

scientific article published on 28 September 2009

Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines

scientific article published on March 2007

Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System

scientific article

Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques ⬇️

scientific article

HER2 Amplification and HER2 Mutation Are Distinct Molecular Targets in Lung Cancers.

scientific article

HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer

scientific article published on 01 June 2006

HER2/neu expression in malignant lung tumors

scientific article published on February 2002

Human Pulmonary Chimerism after Hematopoietic Stem Cell Transplantation ⬇️

scientific article published on April 30, 2003

Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib

scientific article

Identifying and targeting ROS1 gene fusions in non-small cell lung cancer

scientific article

Identifying the Appropriate FISH Criteria for Defining MET Copy Number-Driven Lung Adenocarcinoma through Oncogene Overlap Analysis

scientific article published on June 2016

In Reply

Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy

scientific article

Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients

scientific article published in August 2005

Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients

scientific article published on 2 March 2009

Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.

scientific article

Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study

scientific article published on 5 July 2005

Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas.

scientific article

Initial Clinical Sensitivity and Acquired Resistance to MET Inhibition in MET-Mutated Papillary Renal Cell Carcinoma ⬇️

scientific article published on April 22, 2013

Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression

scientific article

Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas

scientific article published on 16 January 2019

Isolation of immunoresistant human glioma cell clones after selection with alloreactive cytotoxic T lymphocytes: cytogenetic and molecular cytogenetic characterization

scientific article

KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas

scientific article published on July 2015

Kinase gene fusions in defined subsets of melanoma

scientific article published on 19 November 2016

MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme

scientific article

MET-GRB2 Signaling-Associated Complexes Correlate with Oncogenic MET Signaling and Sensitivity to MET Kinase Inhibitors

scientific article published on 29 August 2017

MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib

scientific article published on April 2009

MYC and human telomerase gene (TERC) copy number gain in early-stage non-small cell lung cancer

scientific article

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

scientific article

Molecular characterization of human prostate carcinoma cell lines ⬇️

scientific article published on November 1, 2003

Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer

scientific article published on 01 November 2006

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

scientific article

Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

scientific article published on May 2015

Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer

scientific article published on 01 January 2004

Native and rearranged ALK copy number and rearranged cell count in non-small cell lung cancer: implications for ALK inhibitor therapy

scientific article published on 10 September 2013

Next-Generation Sequencing Identifies and Immunohistochemistry Confirms a Novel Crizotinib-Sensitive ALK Rearrangement in a Patient with Metastatic Non–Small-Cell Lung Cancer ⬇️

scientific article published on September 1, 2012

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

scientific article published on 29 December 2016

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells

scientific article

Oncogene status predicts patterns of metastatic spread in treatment‐naive nonsmall cell lung cancer ⬇️

scientific article published on January 26, 2012

Oncogenic Fusions Involving Exon 19 of ALK ⬇️

scientific article published on December 1, 2012

Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment.

scientific article

Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies

scientific article

Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected].

scientific article published on 16 March 2009

Preclinical studies of gemcitabine and trastuzumab in breast and lung cancer cell lines.

scientific article

Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.

scientific article published on 7 November 2012

Prognostic Patterns in the Histopathology of Pulmonary Adenocarcinoma ⬇️

scientific article published on 05 March 2012

Prospective Study of Gefitinib in Epidermal Growth Factor Receptor Fluorescence In Situ Hybridization–Positive/Phospho-Akt–Positive or Never Smoker Patients With Advanced Non–Small-Cell Lung Cancer: The ONCOBELL Trial

scientific article published on 01 June 2007

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.

scientific article published on 24 August 2015

ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers.

scientific article

Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy ⬇️

scientific article published on April 16, 2012

Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status

scientific article published on 16 March 2009

Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer

scientific article

Resistance mechanisms to targeted therapies in ROS1+ and ALK+ non-small cell lung cancer.

scientific article published on 10 April 2018

Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling

scientific article published on 12 May 2017

Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer

scientific article

Responses to Crizotinib Can Occur in High-Level MET-Amplified Non-Small Cell Lung Cancer Independent of MET Exon 14 Alterations

scientific article published on 21 September 2016

Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression.

scientific article published on 19 March 2018

Screening for 22q11 deletion syndrome among patients with congenital heart defects

scientific article

Selecting lung cancer patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors by immunohistochemistry and fluorescence in situ hybridization--why, when, and how?

scientific article published on July 2006

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension

scientific article

Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer

scientific article

Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study.

scientific article published on 30 November 2011

Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay

scientific article

Suppression of leukemia development caused by PTEN loss ⬇️

scientific article published on January 6, 2011

The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence

scientific article

The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas

scientific article published on 19 July 2013

The use of trastuzumab in the treatment of hormone refractory prostate cancer; phase II trial

scientific article

Tolerable and Effective Combination of Full-Dose Crizotinib and Osimertinib Targeting MET Amplification Sequentially Emerging after T790M Positivity in EGFR-Mutant Non-Small Cell Lung Cancer

scientific article published on 5 March 2017

Understanding and Targeting MET Signaling in Solid Tumors - Are We There Yet?

scientific article

Unusual chemosensitivity of advanced bronchioalveolar carcinoma after gefitinib response and progression: a case report

scientific article published on 01 January 2007

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

scientific article

Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors.

scientific article published on 8 August 2017

Waxing and Waning of MET Amplification in EGFR-Mutated NSCLC in Response to the Presence and Absence of Erlotinib Selection Pressure

scientific article

p95HER2 truncated form in resected non-small cell lung cancer

scientific article

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