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List of works by Cintia Sade de Paiva

A native-like corneal construct using donor corneal stroma for tissue engineering

scientific article

A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells.

scientific article

A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells

scientific article

A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance

scientific article published in September 2004

ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells.

scientific article

Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction.

scientific article

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells

scientific article published on 29 January 2019

Age-related Autoimmune Changes in Lacrimal Glands

scientific article published on 27 February 2019

Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice

scientific article

Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

scientific article published on 05 October 2016

Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome

scientific article published on 18 April 2016

Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome.

scientific article

Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss

scientific article

Assessing the severity of keratitis sicca with videokeratoscopic indices

scientific article

Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease.

scientific article

Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye

scientific article published on 6 November 2011

CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome

scientific article published on 11 September 2013

Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells

scientific article

Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease

scientific article

Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9.

scientific article

Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation.

scientific article published in January 2004

Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.

scientific article

Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice.

scientific article published on November 2012

Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.

scientific article

Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal Keratoconjunctivitis

scientific article published on 01 April 2006

Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas

scientific article published in July 2015

Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice

scientific article published on 7 November 2007

Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline

scientific article

Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway

scientific article

Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium

scientific article published in August 2006

Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye.

scientific article

Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye.

scientific article published on June 2016

Dexamethasone nanowafer as an effective therapy for dry eye disease.

scientific article published on 13 July 2015

Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye.

scientific article published on 6 January 2016

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca

scientific article

Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease

scientific article published on 15 November 2019

Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ

scientific article published on 01 June 2007

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

scientific article published on 01 October 2019

Effect of desiccating stress on mouse meibomian gland function.

scientific article

Effects of Aging in Dry Eye.

scientific article published in January 2017

Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease

scientific article published on 11 April 2015

Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 Production

scientific article published in January 2008

Effects of upper eyelid blepharoplasty on ocular surface sensation and tear production

scientific article published in October 2007

Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay

scientific article published on September 2010

Expression and regulation of cornified envelope proteins in human corneal epithelium

scientific article

Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress

scientific article published on 01 June 2007

Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs.

scientific article

Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease.

scientific article

Goblet cell loss abrogates ocular surface immune tolerance.

scientific article published on 8 February 2018

Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells

scientific article published on 01 September 2018

Highlights from the 21st International Ocular Surface Society meeting

scientific article published on 18 August 2018

Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13.

scientific article published on 22 December 2010

IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells

scientific article published in July 2015

IL-17 disrupts corneal barrier following desiccating stress.

scientific article published on 25 February 2009

IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model

scientific article published on 04 January 2019

Immune - Goblet cell interaction in the conjunctiva

scientific article published on 14 January 2020

Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model.

scientific article

Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model.

scientific article published on May 2016

Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn.

scientific article published on 05 March 2017

Interferon-gamma deficiency protects against aging-related goblet cell loss.

scientific article published on 06 September 2016

Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.

scientific article

Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome

scientific article published on 13 April 2016

Keratoconus-like Topographic Changes in Keratoconjunctivitis Sicca

scientific article published on 01 January 2003

Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway

scientific article published on 7 December 2011

MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions

scientific article

Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease

scientific article published on 13 March 2015

Managing Sjögren's Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy.

scientific article

Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions

scientific article published on 19 January 2020

MicroRNAs in ocular surface and dry eye diseases: Good, bad and healing situations

scientific article published on 5 May 2017

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.

scientific article published on 23 February 2017

Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model

scientific article published on April 2013

NK cells promote Th-17 mediated corneal barrier disruption in dry eye

scientific article (publication date: 2012)

Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis

scientific article published on 31 August 2011

Ocular surface disease and dacryoadenitis in aging C57BL/6 mice.

scientific article published on 03 January 2014

Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice

scientific article published on 21 July 2020

Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions

scientific article

Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland

scientific article

Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome

scientific article published on 28 February 2009

Protective role of commensal bacteria in Sjögren Syndrome

scientific article published on 20 June 2018

Rapamycin Eyedrops Increased CD4<sup>+</sup>Foxp3<sup>+</sup> Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface

scientific article published on 24 November 2020

Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome

scientific article published on 30 November 2018

Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice

scientific article

Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye.

scientific article published in November 2012

Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells

scholarly article by Stephen C Pflugfelder published in September 2018

Sjögren syndrome: what and where are we looking for?

scientific article

Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice

scientific article published on 13 February 2018

Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice.

scientific article published on 7 May 2009

Spontaneous autoimmune dacryoadenitis in aged CD25KO mice

scientific article

Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast

scientific article published on 29 June 2018

T helper cytokines in dry eye disease

scientific article published on 04 September 2013

TFOS DEWS II Report Executive Summary.

scientific article published on 7 August 2017

TFOS DEWS II pathophysiology report

scientific article

TSLP and downstream molecules in experimental mouse allergic conjunctivitis.

scientific article

Tear clearance implications for ocular surface health.

scientific article published on March 2004

Tear cytokine profiles in dysfunctional tear syndrome.

scientific article published on 7 November 2008

The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research

scientific article published in November 2017

The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome

scientific article published on 20 October 2019

The incidence and risk factors for developing dry eye after myopic LASIK.

scientific article

Topical cyclosporine A therapy for dry eye syndrome

scientific article published on 13 September 2019

Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye

scientific article published on 04 December 2013

Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells

scientific article published on October 2006

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