List of works - Ørjan Samuelsen

A diversity of OXA-carbapenemases and class 1 integrons among carbapenem-resistant Acinetobacter baumannii clinical isolates from Sweden belonging to different international clonal lineages

scientific article published on 10 August 2011

A long-term low-frequency hospital outbreak of KPC-producing Klebsiella pneumoniae involving Intergenus plasmid diffusion and a persisting environmental reservoir

scientific article

A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001-15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307

scientific article published on 01 February 2022

A patient with sepsis following a burn injury in Pakistan.

scientific article

A sensitive and specific phenotypic assay for detection of metallo-β-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin

scientific article published on 01 April 2011

A trade-off between the fitness cost of functional integrases and long-term stability of integrons

scientific article

Anti-complement effects of lactoferrin-derived peptides

scientific article

CRISPR-cas subtype I-Fb in Acinetobacter baumannii: evolution and utilization for strain subtyping.

scientific article

Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa

scientific article published on 17 June 2021

Comparison of disk diffusion, Etest and VITEK2 for detection of carbapenemase‐producing Klebsiella pneumoniae with the EUCAST and CLSI breakpoint systems

scientific article published on 01 May 2011

Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233

scientific article published on 02 August 2018

Complete Genome Sequence of a Multidrug-Resistant, blaNDM-1-Expressing Klebsiella pneumoniae K66-45 Clinical Isolate from Norway

scientific article

Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli

scientific article published in Nature Communications

Correction: Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting

scientific article published on 21 February 2018

Cross-border spread of bla NDM-1- and bla OXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019

scientific article published on 01 May 2020

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

scientific article

Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo- -Lactamases

scientific article

Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight.

scientific article published on 19 January 2018

Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark

scientific article published on 23 October 2017

Dissemination of a carbapenem-resistant Acinetobacter baumannii strain belonging to international clone II/sequence type 2 and harboring a novel AbaR4-like resistance island in Latvia

scientific article published on 10 December 2012

Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model

scientific article published on 23 November 2019

Emergence of OXA-carbapenemase- and 16S rRNA methylase-producing international clones of Acinetobacter baumannii in Norway

scientific article

Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden

scientific article published on 13 February 2009

Evaluation of ROSCO Neo-Sensitabs for phenotypic detection and subgrouping of ESBL-, AmpC- and carbapenemase-producing Enterobacteriaceae

scientific article published on 20 March 2012

Evaluation of a new real-time PCR assay (Check-Direct CPE) for rapid detection of KPC, OXA-48, VIM, and NDM carbapenemases using spiked rectal swabs

scientific article

Evaluation of phenotypic tests for the detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa in a low prevalence country

scientific article published on 28 January 2008

Evaluation of the total MBL confirm kit (ROSCO) for detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii.

scientific article

Evolution of β-lactamase-mediated cefiderocol resistance

scientific article published in 2022

Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains

scientific article published in 2022

Fecal colonization of VIM-1-producing Klebsiella pneumoniae and in vivo transfer of multidrug-resistant IncN plasmid in a renal transplant patient.

scientific article published in February 2012

First detection of a carbapenemase-producing Enterobacteriaceae in Iceland.

scientific article published on 2 May 2016

Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya

scientific article

High prevalence of faecal carriage of ESBL-producing Enterobacteriaceae in Norwegian patients with gastroenteritis.

scientific article

His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo- -Lactamase VIM-7

scientific article

Horizontal Plasmid Transfer among Klebsiella pneumoniae Isolates Is the Key Factor for Dissemination of Extended-Spectrum β-Lactamases among Children in Tanzania

scientific article published on 15 July 2020

Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates

scientific article published on 09 June 2020

Hvordan stoppe multiresistente bakterier?

scientific article published on 01 April 2011

Identification of Enterobacteriaceae isolates with OXA-48 and coproduction of OXA-181 and NDM-1 in Norway

scientific article published on 05 March 2013

Identification of NDM-1-producing Enterobacteriaceae in Norway.

scientific article published on 16 December 2010

Identification of VIM-2-producing Pseudomonas aeruginosa from Tanzania is associated with sequence types 244 and 640 and the location of blaVIM-2 in a TniC integron

scientific article

Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex

scientific article published on 29 September 2016

Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting

scientific article published on 7 November 2017

Increased prevalence of aminoglycoside resistance in clinical isolates of Escherichia coli and Klebsiella spp. in Norway is associated with the acquisition of AAC(3)-II and AAC(6')-Ib.

scientific article published on 14 October 2013

Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus.

scientific article

Insights into the global molecular epidemiology of carbapenem non-susceptible clones of Acinetobacter baumannii.

scientific article published on 27 July 2012

Interplay of efflux, impermeability, and AmpC activity contributes to cefuroxime resistance in clinical, non-ESBL-producing isolates of Escherichia coli.

scientific article published in June 2009

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family

scientific article

Lactoferricin B inhibits bacterial macromolecular synthesis in and

scientific article published on 01 August 2004

Large IncHI2-plasmids encode extended-spectrum β-lactamases (ESBLs) in Enterobacter spp. bloodstream isolates, and support ESBL-transfer to Escherichia coli.

scientific article published on 25 June 2013

Low biological cost of carbapenemase-encoding plasmids following transfer from Klebsiella pneumoniae to Escherichia coli

scientific article published on 2 September 2016

Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.

scientific article published on 14 April 2017

Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.

scientific article published on 15 November 2017

Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.

scientific article published on 20 May 2011

Molecular epidemiology of KPC-2- producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437

article

Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion

scientific article

Norwegian patients and retail chicken meat share cephalosporin-resistant Escherichia coli and IncK/blaCMY-2 resistance plasmids

scientific article published on 7 January 2017

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

scientific article published on 27 March 2019

Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study

scholarly article by Bjørg Haldorsen et al published 1 October 2018 in Journal of Antimicrobial Chemotherapy

Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study

scientific article published on 01 October 2018

Pharmacokinetics and Pharmacodynamics of Fosfomycin and its Activity against ESBL-, Plasmid-mediated AmpC- and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model

scientific article published on 26 March 2018

Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection

scientific article published in 2022

Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids

scientific article published on 01 July 2021

Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in Escherichia coli and Klebsiella spp. from Norway and Sweden

scientific article published in April 2010

Proteases in Escherichia coli and Staphylococcus aureus confer reduced susceptibility to lactoferricin B.

scientific article published in October 2002

Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe ⬇️

scientific article published on May 1, 2012

Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1.

scientific article published on 7 December 2015

Sequence Type 410 Is Causing New International High-Risk Clones

article by Louise Roer et al published 18 July 2018 in mSphere

Siste skanse for effektive antibiotika?

scientific article published on 01 August 2012

Species identification and molecular characterization of Acinetobacter spp. blood culture isolates from Norway.

scientific article published on 19 January 2011

Spread of Plasmid-Encoded NDM-1 and GES-5 Carbapenemases among Extensively Drug-Resistant and Pandrug-Resistant Clinical Enterobacteriaceae in Durban, South Africa

scientific article published on 5 March 2018

Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.

scientific article

Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.

scientific article published on 30 May 2017

Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases

scientific article

Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1

scientific article published on 28 May 2020

Structural and computational investigations of VIM-7: insights into the substrate specificity of vim metallo-β-lactamases

scientific article

Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10

scientific article published on 19 July 2020

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

scientific article published on 02 August 2018

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

scientific article published on 08 March 2019

The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011.

scientific article

The chemotherapeutic drug methotrexate selects for antibiotic resistance

scientific article published on 11 December 2021

The fight to keep resistance at bay, epidemiology of carbapenemase producing organisms (CPOs), vancomycin resistant enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA) in Norway, 2006 - 2017

scientific article published in PLoS ONE

The first metallo-beta-lactamase identified in norway is associated with a TniC-like transposon in a Pseudomonas aeruginosa isolate of sequence type 233 imported from Ghana

scientific article published on 17 November 2008

The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee.

scientific article

Use of a Commercially Available Microarray to Characterize Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae

scientific article

ZN148 - a modular synthetic metallo-β-lactamase inhibitor reverses carbapenem-resistance in Gram-negative pathogens in vivo

scientific article published on 16 March 2020

[Broad-spectrum beta-lactamases in Gram-negative bacteria].

scientific article

List of works by Ørjan Samuelsen

A diversity of OXA-carbapenemases and class 1 integrons among carbapenem-resistant Acinetobacter baumannii clinical isolates from Sweden belonging to different international clonal lineages

A long-term low-frequency hospital outbreak of KPC-producing Klebsiella pneumoniae involving Intergenus plasmid diffusion and a persisting environmental reservoir

A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001-15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307

A patient with sepsis following a burn injury in Pakistan.

A sensitive and specific phenotypic assay for detection of metallo-β-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin

A trade-off between the fitness cost of functional integrases and long-term stability of integrons

Anti-complement effects of lactoferrin-derived peptides

CRISPR-cas subtype I-Fb in Acinetobacter baumannii: evolution and utilization for strain subtyping.

Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa

Comparison of disk diffusion, Etest and VITEK2 for detection of carbapenemase‐producing Klebsiella pneumoniae with the EUCAST and CLSI breakpoint systems

Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233

Complete Genome Sequence of a Multidrug-Resistant, blaNDM-1-Expressing Klebsiella pneumoniae K66-45 Clinical Isolate from Norway

Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli

Correction: Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting

Cross-border spread of bla NDM-1- and bla OXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo- -Lactamases

Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight.

Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark

Dissemination of a carbapenem-resistant Acinetobacter baumannii strain belonging to international clone II/sequence type 2 and harboring a novel AbaR4-like resistance island in Latvia

Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model

Emergence of OXA-carbapenemase- and 16S rRNA methylase-producing international clones of Acinetobacter baumannii in Norway

Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden

Evaluation of ROSCO Neo-Sensitabs for phenotypic detection and subgrouping of ESBL-, AmpC- and carbapenemase-producing Enterobacteriaceae

Evaluation of a new real-time PCR assay (Check-Direct CPE) for rapid detection of KPC, OXA-48, VIM, and NDM carbapenemases using spiked rectal swabs

Evaluation of phenotypic tests for the detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa in a low prevalence country

Evaluation of the total MBL confirm kit (ROSCO) for detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii.

Evolution of β-lactamase-mediated cefiderocol resistance

Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains

Fecal colonization of VIM-1-producing Klebsiella pneumoniae and in vivo transfer of multidrug-resistant IncN plasmid in a renal transplant patient.

First detection of a carbapenemase-producing Enterobacteriaceae in Iceland.

Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya

High prevalence of faecal carriage of ESBL-producing Enterobacteriaceae in Norwegian patients with gastroenteritis.

His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo- -Lactamase VIM-7

Horizontal Plasmid Transfer among Klebsiella pneumoniae Isolates Is the Key Factor for Dissemination of Extended-Spectrum β-Lactamases among Children in Tanzania

Host dependent maintenance of a blaNDM-1-encoding plasmid in clinical Escherichia coli isolates

Hvordan stoppe multiresistente bakterier?

Identification of Enterobacteriaceae isolates with OXA-48 and coproduction of OXA-181 and NDM-1 in Norway

Identification of NDM-1-producing Enterobacteriaceae in Norway.

Identification of VIM-2-producing Pseudomonas aeruginosa from Tanzania is associated with sequence types 244 and 640 and the location of blaVIM-2 in a TniC integron

Identification of a novel IMI carbapenemase variant (IMI-9) in Enterobacter cloacae complex

Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting

Increased prevalence of aminoglycoside resistance in clinical isolates of Escherichia coli and Klebsiella spp. in Norway is associated with the acquisition of AAC(3)-II and AAC(6')-Ib.

Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus.

Insights into the global molecular epidemiology of carbapenem non-susceptible clones of Acinetobacter baumannii.

Interplay of efflux, impermeability, and AmpC activity contributes to cefuroxime resistance in clinical, non-ESBL-producing isolates of Escherichia coli.

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family

Lactoferricin B inhibits bacterial macromolecular synthesis in and

Large IncHI2-plasmids encode extended-spectrum β-lactamases (ESBLs) in Enterobacter spp. bloodstream isolates, and support ESBL-transfer to Escherichia coli.

Low biological cost of carbapenemase-encoding plasmids following transfer from Klebsiella pneumoniae to Escherichia coli

Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.

Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014.

Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance.

Molecular epidemiology of KPC-2- producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437

Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion

Norwegian patients and retail chicken meat share cephalosporin-resistant Escherichia coli and IncK/blaCMY-2 resistance plasmids

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study

Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study

Pharmacokinetics and Pharmacodynamics of Fosfomycin and its Activity against ESBL-, Plasmid-mediated AmpC- and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model

Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection

Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids

Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in Escherichia coli and Klebsiella spp. from Norway and Sweden

Proteases in Escherichia coli and Staphylococcus aureus confer reduced susceptibility to lactoferricin B.

Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe ⬇️

Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1.

Sequence Type 410 Is Causing New International High-Risk Clones

Siste skanse for effektive antibiotika?

Species identification and molecular characterization of Acinetobacter spp. blood culture isolates from Norway.

Spread of Plasmid-Encoded NDM-1 and GES-5 Carbapenemases among Extensively Drug-Resistant and Pandrug-Resistant Clinical Enterobacteriaceae in Durban, South Africa

Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.

Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.

Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases

Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1

Structural and computational investigations of VIM-7: insights into the substrate specificity of vim metallo-β-lactamases

Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011.