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List of works by David Alan Young

A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.

scientific article

A negative feedback loop mediated by STAT3 limits human Th17 responses.

scientific article published on 27 June 2014

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

scientific article published on 4 October 2007

An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene.

scientific article published in November 2002

CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development

scientific article published on 17 March 2020

Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced

scientific article published in October 1998

Characterization of the cartilage DNA methylome in knee and hip osteoarthritis

scientific article

Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.

scientific article published on July 2013

Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage

scientific article published on 13 December 2019

DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

scientific article published on 24 January 2020

Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA.

scientific article published on 20 October 2015

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients

scientific article

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

scientific article published on 07 February 2008

Differential gene expression profiling of metalloproteinases and their inhibitors: a comparison between bovine intervertebral disc nucleus pulposus cells and articular chondrocytes.

scientific article published on May 2010

Editorial: More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis ⬇️

scientific article published on March 1, 2013

Epigenetic mechanisms and non-coding RNAs in osteoarthritis.

scientific article published on September 2013

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.

scientific article published on 10 January 2012

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.

scientific article published on 3 June 2011

Expression profiling of metalloproteinases and their inhibitors in cartilage

scientific article (publication date: 2004)

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p

scientific article published on 14 July 2015

Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.

scientific article

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

scientific article published on 12 May 2010

Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage

scientific article published on 03 January 2019

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

scientific article published on 31 May 2012

Interplay between genetics and epigenetics in osteoarthritis

scientific article published on 09 April 2020

Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion

scientific article published on 31 October 2019

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.

scientific article

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.

scientific article published on 6 August 2010

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.

scientific article

MMP28 gene expression is regulated by Sp1 transcription factor acetylation.

scientific article published on 14 April 2010

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.

scientific article published in July 2010

Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes.

scientific article published on May 2013

Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.

scientific article published on January 2006

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk

scientific article

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2.

scientific article

OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals

scientific article published on 19 October 2020

Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.

scientific article published on 5 May 2005

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.

scientific article published on 04 December 2014

Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

scientific article published on 22 January 2009

Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.

scientific article published on 8 April 2014

Proteinases involved in matrix turnover during cartilage and bone breakdown.

scientific article

Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.

scientific article published on 19 September 2006

Recent advances in understanding the regulation of metalloproteinases

scientific article published on 18 February 2019

Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis

scientific article published on 02 March 2017

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.

scientific article published on 10 March 2008

The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1

scientific journal article

The expression and function of microRNAs in chondrogenesis and osteoarthritis.

scientific article

The first international workshop on the epigenetics of osteoarthritis

scientific article

The function of microRNAs in cartilage and osteoarthritis

scientific article published on 01 September 2019

The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.

scientific article

The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells.

scientific article published on 30 October 2017

The microRNA-29 family in cartilage homeostasis and osteoarthritis

scientific journal article

Understanding CpG methylation in the context of osteoarthritis

scientific article published on 01 December 2012

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.

scientific article

microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs

scientific article published on 13 July 2020

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