List of works - Rosmarie Friemann

"Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes.

scientific article published on 8 December 2017

Active site residues controlling substrate specificity in 2-nitrotoluene dioxygenase from Acidovorax sp. strain JS42.

scientific article

Automation aided optimization of cloning, expression and purification of enzymes of the bacterial sialic acid catabolic and sialylation pathways enzymes for structural studies

scientific article

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

scientific article published on 29 January 2019

Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125

scientific article

Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum.

scientific article

Crystal structure of plant pectin methylesterase

scientific article

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

scientific article published on 14 February 2017

Determining Rieske cluster reduction potentials

scientific article

Inhibitor binding mode and allosteric regulation of Na-glucose symporters

scientific article published on 07 December 2018

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

scientific article published on 31 March 2021

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation

scientific article

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

scientific article published on 16 March 2018

Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8.

scientific article published on 27 June 2009

Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems

scientific article

Purification, crystallization and preliminary X-ray diffraction studies of the three components of the toluene 2,3-dioxygenase enzyme system.

scientific article

Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase.

scientific article published on 7 April 2005

Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus

scientific article

Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site

scientific article

Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions

scientific article

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

scientific article

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

scientific article published on 09 July 2018

The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus

scientific article published on 15 January 2020

Transcription factor clusters regulate genes in eukaryotic cells.

scientific article published on 25 August 2017

Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics

scientific article published on 20 September 2012

List of works by Rosmarie Friemann

"Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes.

Active site residues controlling substrate specificity in 2-nitrotoluene dioxygenase from Acidovorax sp. strain JS42.

Automation aided optimization of cloning, expression and purification of enzymes of the bacterial sialic acid catabolic and sialylation pathways enzymes for structural studies

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125

Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum.

Crystal structure of plant pectin methylesterase

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

Determining Rieske cluster reduction potentials

Inhibitor binding mode and allosteric regulation of Na-glucose symporters

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8.

Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems

Purification, crystallization and preliminary X-ray diffraction studies of the three components of the toluene 2,3-dioxygenase enzyme system.

Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase.

Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus

Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site

Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus

Transcription factor clusters regulate genes in eukaryotic cells.

Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics