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List of works by Claire Simons

1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase

scientific article published in July 1999

4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors

scientific article published in 2022

6-Azathymidine-4′-thionucleosides: synthesis and antiviral evaluation

scientific article published in January 2008

6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains

scientific article

A homology model for Clostridium difficile methionyl tRNA synthetase: active site analysis and docking interactions.

scientific article published on 2 November 2010

A note: ortho-phthalaldehyde: proposed mechanism of action of a new antimicrobial agent.

scientific article published in October 2000

Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea

article

Benzofuran- and furan-2-yl-(phenyl)-3-pyridylmethanols: synthesis and inhibition of P450 aromatase

scientific article published in April 2005

Comparative modeling of 25-hydroxycholesterol-7α-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

scientific article published on 23 July 2019

Design and synthesis of substituted imidazole and triazoleN-phenylbenzo[d]oxazolamine inhibitors of retinoic acid metabolizing enzyme CYP26

article published in 2008

Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues

scientific article published on 28 October 2021

Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3, 4-dihydronaphthalen-1(2H)-one on all-trans and 13-cis-retinoic acid levels in plasma quantified by high perfomance liquid chromatography coupled to tandem mass spectrometry

scientific article published in June 2005

HPLC enantiomeric resolution of novel aromatase inhibitors on cellulose- and amylose-based chiral stationary phases under reversed phase mode

scientific article published in 2000

Homology model of 1α,25-dihydroxyvitamin D3 24-hydroxylase cytochrome P450 24A1 (CYP24A1): Active site architecture and ligand binding

article

Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding

scientific article

Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains

scientific article published in November 2004

Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells.

scientific article published on 14 February 2006

Inhibition of retinoic acid metabolising enzymes by 2-(4-aminophenylmethyl)-6-hydroxy-3,4-dihydronaphthalen-1(2H)-one and related compounds

scientific article published in February 2003

Methyl 5-O-benzoyl-2,3-oxazole-D-ribofuranoside: a useful intermediate for the synthesis of conformationally restrained nucleosides.

scientific article published in April 2001

Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies

scientific article published on 29 October 2020

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

scientific article published on 29 November 2017

Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells

scientific article

Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation

scientific article published on June 2004

Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation

scientific article published in August 2004

Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold

scientific article

Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation

scientific article

Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays.

scientific article published on November 2005

Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.

scientific article published in February 2006

Prodrug to probe solution HFA pMDI formulation and pulmonary esterase activity

scientific article published in February 2000

Recent advances in antiviral nucleoside and nucleotide therapeutics.

scientific article

Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates

scientific article published on 23 March 2011

Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation

scientific article published on 8 September 2014

Some 1,2-diphenylethane derivatives as inhibitors of retinoic acid--metabolising enzymes

scientific article published in October 2003

Some aryl substituted 2-(4-nitrophenyl)-4-oxo-4-phenylbutanoates and 3-(4-nitrophenyl)-1-phenyl-1,4-butanediols and related compounds as inhibitors of rat liver microsomal retinoic acid metabolising enzymes

scientific article published in December 2003

Studies on the mechanisms of the antibacterial action of ortho-phthalaldehyde

scientific article published in October 1999

Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives

scientific article published in November 2004

Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones

scientific article published on 8 July 2010

Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.

scientific article published on 9 June 2010

Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.

scientific article published on 3 February 2006

Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.

scientific article

Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis

scientific article published in April 2005

Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).

scientific article

Synthesis and biological evaluation of novel 2′-deoxy-4′-thio-imidazole nucleosides

scientific article published in March 1999

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

scientific article published on 27 February 2019

Synthesis and biological evaluation of pyridin-2-one nucleosides.

scientific article published in April 2001

Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action.

scientific article published on 24 April 2012

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