List of works - Emidio Camaioni

2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation

scientific article published on 01 May 1994

2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.

scientific article published in April 1995

2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors

scientific article

2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors

scientific article published on 01 October 1996

3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.

scientific article published on January 2004

3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats

scientific article published on 17 February 2006

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

scientific article

Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles

scientific article published on 01 January 1994

Adenosine deaminase inhibitors: synthesis, diastereoisomeric resolution and biological activity of 1-(2-hydroxy-3-nonyl)-1,2,4-triazole-3-carboxamide

scientific article published on 01 June 1997

Adenosine deaminase: functional implications and different classes of inhibitors

scientific article

Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA

scientific article published on 01 December 1997

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry

scientific article published on 16 May 2017

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid

scientific article

Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).

scientific article published in June 2003

Boosting Immunity and Management against Wheat Fusarium Diseases by a Sustainable, Circular Nanostructured Delivery Platform

scientific article published in 2023

Characterization of thymoquinone binding to human α₁-acid glycoprotein

scientific article published on 29 March 2012

Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids

scientific article published on 22 May 2010

Chiral separation of helical chromenes with chloromethyl phenylcarbamate polysaccharide-based stationary phases.

scientific article published on 12 December 2017

Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.

scientific article published on October 2015

Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids

scientific article published on 16 June 2007

Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors

scientific article published on 01 January 1998

Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids

scientific article published on 06 November 2008

Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

scientific article

Dexpramipexole blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models

scientific article published on 01 April 2020

Dexpramipexole improves bioenergetics and outcome in experimental stroke

scientific article

Enantioselective HPLC Analysis to Assist the Chemical Exploration of Chiral Imidazolines

scientific article published on 02 February 2020

Evaluation of (arene)Ru(II) complexes of curcumin as inhibitors of dipeptidyl peptidase IV.

scientific article

Exploring the effect of PARP-1 flexibility in docking studies

scientific article

Fast chromatographic determination of the bile salt critical micellar concentration

scientific article published on 14 May 2011

From polypharmacology to target specificity: the case of PARP inhibitors

scientific article published on January 2013

Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.

scientific article

Hydrophobic Amino Acid Content in Onions as Potential Fingerprints of Geographical Origin: The Case of

scientific article published on 25 May 2018

Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.

scientific article published on 19 February 2018

Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy

scientific article published on 22 July 2014

Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography

scientific article published on January 2011

Metabotropic glutamate receptors: structure and new subtype-selective ligands.

scientific article

Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis

scientific article published on 01 November 2001

Modulation of apoptosis in human lymphocytes by adenosine analogues

scientific article published on 01 September 1998

N-Decyl-S-trityl-(R)-cysteine, a new chiral selector for "green" ligand-exchange chromatography applications

scientific article published on 5 February 2017

New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures

scientific article published on 19 March 2020

New substituted 9-alkylpurines as adenosine receptor ligands

scientific article

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia

scientific article published on 20 February 2003

On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.

scientific article published in June 2008

Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent

scientific article

Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.

scientific article published in December 1994

Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure

scientific article published on May 2009

Rat brain guanosine binding site. Biological studies and pseudo-receptor construction.

scientific article

Scaffold hopping approach on the route to selective tankyrase inhibitors

scientific article published on 5 October 2014

Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids

scientific article published in August 2002

Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist

scientific article published in February 2004

Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

scientific article published on May 1999

Synthesis and receptor affinity of polysubstituted adenosines

scientific article published on 01 April 1999

Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5?-phosphate and phosphonate derivatives as P2 receptor antagonists ⬇️

scientific article published on October 1, 1998

Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors

scientific article published on 7 October 2017

The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities.

scientific article published on 21 December 2015

The Relationship between S. aureus and Branched-Chain Amino Acids Content in Composite Cow Milk

scientific article published on 16 November 2019

Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin

scientific article published on 18 February 2010

Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.

scientific article published in September 2003

List of works by Emidio Camaioni

2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation

2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.

2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors

2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors

3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.

3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles

Adenosine deaminase inhibitors: synthesis, diastereoisomeric resolution and biological activity of 1-(2-hydroxy-3-nonyl)-1,2,4-triazole-3-carboxamide

Adenosine deaminase: functional implications and different classes of inhibitors

Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid

Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).

Boosting Immunity and Management against Wheat Fusarium Diseases by a Sustainable, Circular Nanostructured Delivery Platform

Characterization of thymoquinone binding to human α₁-acid glycoprotein

Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids

Chiral separation of helical chromenes with chloromethyl phenylcarbamate polysaccharide-based stationary phases.

Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.

Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids

Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors

Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids

Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

Dexpramipexole blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models

Dexpramipexole improves bioenergetics and outcome in experimental stroke

Enantioselective HPLC Analysis to Assist the Chemical Exploration of Chiral Imidazolines

Evaluation of (arene)Ru(II) complexes of curcumin as inhibitors of dipeptidyl peptidase IV.

Exploring the effect of PARP-1 flexibility in docking studies

Fast chromatographic determination of the bile salt critical micellar concentration

From polypharmacology to target specificity: the case of PARP inhibitors

Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.

Hydrophobic Amino Acid Content in Onions as Potential Fingerprints of Geographical Origin: The Case of

Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.

Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy

Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography

Metabotropic glutamate receptors: structure and new subtype-selective ligands.

Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis

Modulation of apoptosis in human lymphocytes by adenosine analogues

N-Decyl-S-trityl-(R)-cysteine, a new chiral selector for "green" ligand-exchange chromatography applications

New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures

New substituted 9-alkylpurines as adenosine receptor ligands

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia

On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.

Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent

Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.

Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure

Rat brain guanosine binding site. Biological studies and pseudo-receptor construction.

Scaffold hopping approach on the route to selective tankyrase inhibitors

Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids

Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist

Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

Synthesis and receptor affinity of polysubstituted adenosines

Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5?-phosphate and phosphonate derivatives as P2 receptor antagonists ⬇️

Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors

The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities.

The Relationship between S. aureus and Branched-Chain Amino Acids Content in Composite Cow Milk

Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin

Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.