List of works - James Driscoll

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

scientific article

Biotransformation and bioactivation reactions - 2018 literature highlights

scientific article published on 01 May 2019

Biotransformation and bioactivation reactions of alicyclic amines in drug molecules

scientific article

Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species.

scientific article published in September 2009

Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.

scientific article published in May 2010

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

scientific article published on 26 April 2016

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

scientific article published on 12 August 2017

In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin

scientific article published on 01 October 2018

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

scientific article published on 20 July 2017

Metabolite Profiling and Reaction Phenotyping for the in Vitro Assessment of the Bioactivation of Bromfenac †

scientific article published on 23 December 2019

Novel advances in biotransformation and bioactivation research-2019 year in review

scientific article published on 09 July 2020

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition

scientific article published on 25 September 2011

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

scientific article published on 21 March 2013

Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.

scientific article published on 15 March 2007

Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy

scientific article published on 20 October 2020

Pyrimidine benzamide-based thrombopoietin receptor agonists.

scientific article published on 31 July 2007

Role of Glucuronidation and P450 Oxidation in the Bioactivation of Bromfenac

scientific article published on 02 April 2018

The identification of orally bioavailable thrombopoietin agonists.

scientific article published on 15 January 2009

List of works by James Driscoll