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List of works by Alfred S. Cheng

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients

scientific article published on 9 December 2014

A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha

scientific article published on 29 June 2006

A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy.

scientific article published on 11 July 2013

A novel role of hepatic epithelial transforming growth factor-β signaling in cholangiocarcinogenesis

scientific article published on March 2016

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

scientific article published in Nature Communications

Alliance of epigenetic forces for the activation of oncogenic Wnt/β-catenin signaling.

scientific article published in March 2013

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

scientific article published in Nature Communications

Androgen receptor drives hepatocellular carcinogenesis by activating enhancer of zeste homolog 2-mediated Wnt/β-catenin signaling

scientific article published on 24 August 2018

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes

scientific article

Bioengineering and characterization of physeal transplant with physeal reconstruction potential

scientific article published in August 2003

Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase.

scientific article published in March 2018

C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.

scientific article published on 19 March 2016

CCRK is a novel signalling hub exploitable in cancer immunotherapy.

scientific article published on 19 January 2018

CUL4B: a novel epigenetic driver in Wnt/β-catenin-dependent hepatocarcinogenesis

scientific article

Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development

scientific article

Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice.

scientific article

Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis.

scientific article

Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis

scientific article published on 17 January 2014

Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer.

scientific article published on 29 June 2011

Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.

scientific article published on February 2006

Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumourigenesis.

scientific article published on 22 April 2016

Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

scientific article published on 25 June 2015

Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells

scientific article published on 8 January 2014

Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma.

scientific article published on April 2014

Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10.

scientific article published on 22 January 2016

EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma

scientific article published on 4 September 2016

EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.

scientific article published on 21 April 2011

Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice

scientific article published on 27 May 2008

Emerging role of Hippo pathway in gastric and other gastrointestinal cancers

scientific article

Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity.

scientific article

Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis

scientific article

Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer ⬇️

scientific article published on January 7, 2011

Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients.

scientific article

Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease

scientific article published on 07 September 2013

Epigenetic regulation of signaling pathways in cancer: Role of the histone methyltransferase EZH2 ⬇️

scientific article published on January 1, 2011

Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development.

scientific article published on 27 July 2015

Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.

scientific article published on 12 December 2014

Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer

scientific article published on 16 August 2016

Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis

scientific article published on 01 February 2001

Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2.

scientific article published on October 2004

Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis.

scientific article

Expression of cyclooxygenase-2 in chronic hepatitis B and the effects of anti-viral therapy.

scientific article published in February 2002

FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.

scientific article published on 6 August 2018

FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells.

scientific article

Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells.

scientific article published on 21 January 2013

Gender Differences in Adipocyte Metabolism and Liver Cancer Progression

scientific article

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

scientific article published on 18 May 2008

Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis.

scientific article published on 8 October 2012

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

scientific article

High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B.

scientific article

Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma

scientific article published on 17 September 2015

Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer.

scientific article published on 24 October 2012

Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells.

scientific article

IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis.

scientific article published on 11 April 2017

Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.

scientific article

Interaction of adipokines and hepatitis B virus on histological liver injury in the Chinese.

scientific article published on 6 October 2009

Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis

scientific article published on 01 September 2018

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function.

scientific article published on 19 March 2014

Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis ⬇️

scientific article published on 29 March 2019

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

scientific article published on 25 September 2015

NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.

scientific article published on 15 November 2010

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

scientific article

New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation

scientific article published on 19 February 2019

Oncogenes without a Neighboring Tumor-Suppressor Gene Are More Prone to Amplification

scientific article published on 12 January 2017

Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma ⬇️

scientific article published on January 17, 2012

PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis.

scientific article published on 23 April 2018

PPARgamma is essential for protection against nonalcoholic steatohepatitis.

scientific article published on 8 April 2010

Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial-mesenchymal transition

scientific article

RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma

scientific article published on 12 February 2007

SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.

scientific article published on 13 December 2017

START: a system for flexible analysis of hundreds of genomic signal tracks in few lines of SQL-like queries.

scientific article published on 22 September 2017

TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis.

scientific article published on 31 July 2017

TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy

scientific article

Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma

scientific article published on 10 May 2019

Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma.

scientific article

Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma.

scientific article published on 23 April 2014

Targeting the miR-630/YAP1/ERK feedback loop in epidermal growth factor receptor-mutated lung adenocarcinomas

scientific article published on 01 November 2018

The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma.

scientific article published in September 2017

The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis

scientific article published on 20 February 2017

The Janus face of cathelicidin in tumorigenesis.

scientific article published on January 2014

The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis

scientific article

The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis.

scientific article published on 20 March 2017

The oncogenic role of Epstein-Barr virus-encoded microRNAs in Epstein-Barr virus-associated gastric carcinoma

scientific article published on 9 October 2017

The physiological role of Motin family and its dysregulation in tumorigenesis

scientific article published on 12 April 2018

The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells.

scientific article published on 7 October 2014

Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma

scientific article published on 07 June 2007

Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice.

scientific article published on 7 July 2008

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.

scientific article published on 28 May 2015

Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy.

scientific article

Up-regulation of cyclooxygenase-1 and -2 in human gastric ulcer

scientific article published on 01 January 2001

Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis

scientific article

Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma

scientific article

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.

scientific article published on 21 January 2016

let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis.

scientific article

miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis

scientific article

miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis

scientific article

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