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List of works by Javier Garzón

Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization

scientific article

Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice.

scientific article published in March 2001

Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia.

scientific article

Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice.

scientific article published on May 1999

Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.

scientific article

Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.

scientific article

Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.

scientific article

Changes in the number of dendritic spines in the medial preoptic area during a premature long-term social isolation in rats

scientific article published on 01 January 1991

Differential modification of opiate receptor activity by arylsulfatase treatment

scientific article published on 01 May 1983

Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.

scientific article published on September 2012

Dynorphin-(1-13): the effect of in vivo treatment on opiate bindings in vitro

scientific article

Effect of ICV pertussis toxin and N-ethylmaleimide on the levels of substance P and serotonin in brain and spinal cord of the rat

scientific article published on 01 January 1990

Effect of human B-endorphin on the binding of different opiates to mouse brain membranes

scientific article published in January 1983

Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats

scientific article published on 01 January 1990

Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS

scientific article (publication date: June 2005)

Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.

scientific article

GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.

scientific article published on 10 July 2012

GX/Z Is Regulated by μ But Not δ Opioid Receptors in the Stimulation of the Low Km GTPase Activity in Mouse Periaqueductal Grey Matter ⬇️

scientific article published on June 1, 1997

HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity

scientific article published on 05 October 2013

In vivo modulation of G proteins and opioid receptor function by antisense oligodeoxynucleotides.

scientific article

Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.

scientific article published in August 1998

Intrathecal pertussis toxin attenuates the morphine withdrawal syndrome in normal but not in arthritic rats.

scientific article

Intrinsic analgesic activity of human beta lipotropin in rats: comparison with other opioid peptides.

scientific article published in July 1981

Local changes in GTP-binding protein immunoreactivities in human epileptogenic neocortex.

scientific article published in March 1998

Mastoparan reduces the supraspinal analgesia mediated by mu/delta-opioid receptors in mice.

scientific article

Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins

scientific article

Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling

scientific article

Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.

scientific article

NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.

scientific article

NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.

scientific article published on 27 March 2011

Nitric oxide and zinc-mediated protein assemblies involved in mu opioid receptor signaling.

scientific article published on 11 May 2013

Opiates as antidepressants.

scientific article published on January 2009

Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse

scientific article published on 01 August 1988

Portentiation of the analgesia induced in rats by morphine or [D-Ala2]-met-enkephalinamide after inhibition of brain type B monoamine oxidase: the role of phenylethylamine

scientific article published on 01 August 1980

RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Galphaz subunits

scientific article

RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.

scientific article

RGS9 proteins facilitate acute tolerance to mu-opioid effects

scientific article (publication date: February 2001)

RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.

scientific article published on 19 May 2011

SUMO-SIM interactions regulate the activity of RGSZ2 proteins

scientific article

Sensitivity to μ‐opioid receptor‐mediated anti‐nociception is determined by cross‐regulation between μ‐ and δ‐opioid receptors at supraspinal level ⬇️

scientific article published on May 1, 2012

Stimulation of mu- and delta-opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of delta-receptors.

scientific article published in June 1999

Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.

scientific article published on 9 August 2006

Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits

scientific journal article

The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects.

scientific article

The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter.

scientific article published in January 1998

The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation

scientific article published on 14 December 2010

The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.

scientific article

The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain.

scientific article published on 13 March 2013

Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.

scientific article published in March 1999

Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception

scientific article published on 01 October 1999

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