List of works - Slawomir Filipek

A Gating Mechanism of the Serotonin 5-HT3 Receptor

scientific article published on 19 April 2016

A Hybrid Approach to Structure and Function Modeling of G Protein-Coupled Receptors

scientific article published on 29 March 2016

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

scientific article published on 27 February 2004

A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor

scientific article

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

scientific article

A novel dominant D109A CRYAB mutation in a family with myofibrillar myopathy affects αB-crystallin structure.

scientific article

A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene.

scientific article

Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human αB-crystallin.

scientific article published on 28 October 2013

Action of molecular switches in GPCRs--theoretical and experimental studies.

scientific article

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

scientific article published on 09 September 2014

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

scientific article published on 23 April 2021

Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.

scientific article published on 4 September 2012

Amyloidogenic Properties of Short α-L-Glutamic Acid Oligomers

scientific article published on 18 September 2015

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

scientific article published on 24 March 2014

Approaches for Differentiation and Interconverting GPCR Agonists and Antagonists

scientific article published in January 2018

Aquaporin-graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

scientific article

Arginine interactions with anatase TiO2 (100) surface and the perturbation of 49Ti NMR chemical shifts--a DFT investigation: relevance to Renu-Seeram bio solar cell

scientific article

Arrestin interaction with rhodopsin: conceptual models

scientific article published in January 2006

Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene

scientific article

Bio-batteries and bio-fuel cells: leveraging on electronic charge transfer proteins.

scientific article published on March 2009

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

scientific article

Ca2+ -dependent regulation of phototransduction

scientific article published on 12 March 2008

CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1.

scientific article

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

scientific article

Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies

scientific article

Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening

scientific article

Co-translational association of cell-free expressed membrane proteins with supplied lipid bilayers

scientific article

Computational approach for the assessment of inhibitory potency against beta-amyloid aggregation.

scientific article published on 24 November 2016

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

scientific article published on 23 April 2019

Cross-linked glucose oxidase clusters for biofuel cell anode catalysts

scientific article published on 23 July 2013

Cryo-EM structure of the native rhodopsin dimer in nanodiscs

scientific article published on 09 August 2019

Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors.

scientific article

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

scientific article published on 12 August 2017

Detecting molecular interactions that stabilize native bovine rhodopsin

scientific article published on 20 February 2006

Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes

scientific article published on 16 May 2019

Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes).

scientific article

ERK1/2 is dephosphorylated by a novel phosphatase – CacyBP/SIP ⬇️

scientific article published on November 24, 2010

Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene

scientific article published on 5 September 2007

Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

scientific article published on 24 April 2020

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

scientific article

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

scientific article

Exploring a new ligand binding site of G protein-coupled receptors

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

scientific article

Functional characterization of rhodopsin monomers and dimers in detergents

scientific article

G protein-coupled receptor rhodopsin: a prospectus

scientific article

G protein-coupled receptors--recent advances

scientific article

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.

scientific article published in July 2018

GPCRmd uncovers the dynamics of the 3D-GPCRome

scientific article published on 13 July 2020

Generation and characterization of a novel, permanently active S100P mutant

scientific article published on 08 December 2008

Genetic aspects of Alzheimer's disease.

scientific article published on January 2004

High-level cell-free production of membrane proteins with nanodiscs.

scientific article

Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor

scientific article

Identification of Specific Effect of Chloride on the Spectral Properties and Structural Stability of Multiple Extracellular Glutamic Acid Mutants of Bacteriorhodopsin

scientific article

Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23.

scientific article published on 27 June 2017

Is rhodopsin dimeric in native retinal rods?

scientific article published in Nature

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin

scientific article

Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.

scientific article published in September 2006

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations

scientific article (publication date: 2013)

Low-temperature molecular dynamics simulations of horse heart cytochrome c and comparison with inelastic neutron scattering data.

scientific article

Lyotropic Cubic Phases for Drug Delivery: Diffusion and Sustained Release from the Mesophase Evaluated by Electrochemical Methods

scientific article published on 10 November 2015

Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein

scientific article

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

scientific article published on 31 May 2016

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.

scientific article

Modulation of molecular interactions and function by rhodopsin palmitylation

scientific article published on May 2009

Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery

scientific article published on 22 March 2021

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

scientific article

Molecular effects of encapsulation of glucose oxidase dimer by graphene

scholarly article in RSC Advances, vol. 5 no. 18, 2015

Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs

scientific article published in April 2008

Molecular switches in GPCRs

scientific article published on 01 April 2019

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives

scientific article published on 28 October 2015

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

scientific article

Non-peptide ligand binding to the formyl peptide receptor FPR2--A comparison to peptide ligand binding modes.

scientific article

Oligomerization of G protein-coupled receptors: past, present, and future

scientific article published on December 2004

Organization of rhodopsin molecules in native membranes of rod cells--an old theoretical model compared to new experimental data

scientific article

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

scientific article

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

scientific article

Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.

scientific article published on 12 May 2017

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

scientific article published on 13 March 2017

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

scientific article

Protein-carbon nanotube sensors: single platform integrated micro clinical lab for monitoring blood analytes

scientific article published in January 2012

Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome

scientific article published on 23 July 2020

Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment

scientific article published on 19 April 2006

PyMOL and Inkscape Bridge the Data and the Data Visualization

scientific article published in December 2016

Quaternary structures of opsin in live cells revealed by FRET spectrometry

scientific article published on 13 September 2016

Recognition of the let-7g miRNA precursor by human Lin28B

scientific article

Rhodopsin dimers in native disc membranes

scientific article published in Nature

Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice

scientific article

Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function

scientific article

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

scholarly article

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

scientific article

Stabilizing effect of Zn2+ in native bovine rhodopsin

scientific article

Structural investigation of the C-terminal catalytic fragment of presenilin 1

scientific article

Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations.

scientific article

Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments

scientific article

Study on the feasibility of bacteriorhodopsin as bio-photosensitizer in excitonic solar cell: a first report.

scientific article published on March 2009

Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents.

scientific article

The G protein-coupled receptor rhodopsin in the native membrane

scientific article

The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations

scientific article published on 21 April 2020

The Molecular Mechanism of P2Y1 Receptor Activation

scientific article published on 27 July 2016

The Principles of Ligand Specificity on beta-2-adrenergic receptor

scientific article (publication date: 5 October 2016)

The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex

scientific article published on 24 June 2021

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors

scientific article

The effect of triple glutamic mutations E9Q/E194Q/E204Q on the structural stability of bacteriorhodopsin

scientific article published on 10 January 2014

The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors.

scientific article published on 12 May 2015

The role of water and sodium ions in the activation of the μ-opioid receptor

scientific article

The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations

scientific article

The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes

scientific article

Towards improved quality of GPCR models by usage of multiple templates and profile-profile comparison

scientific article

Two desmin gene mutations associated with myofibrillar myopathies in Polish families

scientific article

Two novel presenilin 1 gene mutations connected with frontotemporal dementia-like clinical phenotype: Genetic and bioinformatic assessment

scientific article published in July 2006

Ubiquitous amyloids

scientific article

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

scientific article

Understanding the inhibitory effect of highly potent and selective archazolides binding to the vacuolar ATPase

scientific article

W246(6.48) opens a gate for a continuous intrinsic water pathway during activation of the adenosine A2A receptor

scientific article published on 17 November 2014

alpha-asarone congeners as hypolipidemic agents. Pseudoreceptor versus minireceptor modeling

scientific article published on 01 November 2000

List of works by Slawomir Filipek

A Gating Mechanism of the Serotonin 5-HT3 Receptor

A Hybrid Approach to Structure and Function Modeling of G Protein-Coupled Receptors

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

A novel dominant D109A CRYAB mutation in a family with myofibrillar myopathy affects αB-crystallin structure.

A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene.

Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human αB-crystallin.

Action of molecular switches in GPCRs--theoretical and experimental studies.

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.

Amyloidogenic Properties of Short α-L-Glutamic Acid Oligomers

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

Approaches for Differentiation and Interconverting GPCR Agonists and Antagonists

Aquaporin-graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

Arginine interactions with anatase TiO2 (100) surface and the perturbation of 49Ti NMR chemical shifts--a DFT investigation: relevance to Renu-Seeram bio solar cell

Arrestin interaction with rhodopsin: conceptual models

Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene

Bio-batteries and bio-fuel cells: leveraging on electronic charge transfer proteins.

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

Ca2+ -dependent regulation of phototransduction

CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1.

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies

Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening

Co-translational association of cell-free expressed membrane proteins with supplied lipid bilayers

Computational approach for the assessment of inhibitory potency against beta-amyloid aggregation.

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Cross-linked glucose oxidase clusters for biofuel cell anode catalysts

Cryo-EM structure of the native rhodopsin dimer in nanodiscs

Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors.

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

Detecting molecular interactions that stabilize native bovine rhodopsin

Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes

Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes).

ERK1/2 is dephosphorylated by a novel phosphatase – CacyBP/SIP ⬇️

Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene

Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Exploring a new ligand binding site of G protein-coupled receptors

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

Functional characterization of rhodopsin monomers and dimers in detergents

G protein-coupled receptor rhodopsin: a prospectus

G protein-coupled receptors--recent advances

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.

GPCRmd uncovers the dynamics of the 3D-GPCRome

Generation and characterization of a novel, permanently active S100P mutant

Genetic aspects of Alzheimer's disease.

High-level cell-free production of membrane proteins with nanodiscs.

Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor

Identification of Specific Effect of Chloride on the Spectral Properties and Structural Stability of Multiple Extracellular Glutamic Acid Mutants of Bacteriorhodopsin

Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23.

Is rhodopsin dimeric in native retinal rods?

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin

Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations

Low-temperature molecular dynamics simulations of horse heart cytochrome c and comparison with inelastic neutron scattering data.

Lyotropic Cubic Phases for Drug Delivery: Diffusion and Sustained Release from the Mesophase Evaluated by Electrochemical Methods

Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.

Modulation of molecular interactions and function by rhodopsin palmitylation

Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

Molecular effects of encapsulation of glucose oxidase dimer by graphene

Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs

Molecular switches in GPCRs

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

Non-peptide ligand binding to the formyl peptide receptor FPR2--A comparison to peptide ligand binding modes.

Oligomerization of G protein-coupled receptors: past, present, and future

Organization of rhodopsin molecules in native membranes of rod cells--an old theoretical model compared to new experimental data

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.