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List of works by Robert Layfield

5‐HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms ⬇️

scientific article published on September 1, 2012

A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

scientific article published on February 2012

A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice

scientific article published on 21 April 2011

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

scientific article published on 20 August 2016

Adult Paget's disease of bone: a review.

scientific article published on 17 February 2017

Application of formalin fixation to the purification of amyloid proteins

scientific article published on 01 November 1997

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology.

scientific article published on 16 November 2007

Autophagy receptor defects and ALS-FTLD.

scientific article

Boning up on autophagy: the role of autophagy in skeletal biology

scientific article (publication date: 2014)

Capillary electrophoresis assay for ubiquitin carboxyl-terminal hydrolases with chemically synthesized ubiquitin-valine as substrate

scientific article published in May 1997

Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions

scientific article

Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit

scientific article published on 02 August 2013

Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone

scientific article

Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms.

scientific article

Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes.

scientific article

Cyclisation of Lys48-linked diubiquitin in vitro and in vivo

scientific article published on 17 October 2012

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

scientific article published on 09 May 2016

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

scientific article published in August 2008

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

scientific article

Disruption of ubiquitin-mediated processes in diseases of the brain and bone

scientific article published on June 2008

Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones

scientific article published on 05 January 2011

Does an inhibition of the ubiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?

scientific article

Effects of endotoxaemia on protein metabolism in rat fast-twitch skeletal muscle and myocardium

scientific article

Electrophoretic separation of ubiquitin and single amino acid residue ubiquitin extensions using a commercial modified acrylamide gel electrophoresis system: an assay to determine catalytic capacities of deubiquitinating enzymes

scientific article published on 01 March 1999

Erratum

scholarly article published in Autophagy

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours

scientific article

Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization

scientific article

Growth-promoting effects of different fractions of extra-embryonic coelomic fluid on embryonic development

scientific article published on 01 August 2000

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration

scientific article published on 7 June 2009

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition

scientific article published on 9 May 2011

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex

scientific article published on 29 September 2011

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

article

Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational Control

article

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

scientific article published on August 2000

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

article

Intracellular aggregation of human stefin B: confocal and electron microscopy study.

scientific article

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

scientific article published on 9 March 2015

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis

scientific article published in June 2009

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

scientific article published on 06 May 2006

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

article

Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.

scientific article published on April 2016

Method for the Purification of Endogenous Unanchored Polyubiquitin Chains

scientific article published in January 2016

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

scientific article published on 15 March 2010

Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

scientific article published on 01 May 1996

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

scientific article published on 23 April 2013

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences

scientific article published on 22 March 2004

Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues.

scientific article published in May 2005

Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration

scientific article

PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

scientific article published on 31 May 2007

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

scientific article

Pathogenesis of Paget disease of bone.

scientific article published on 29 April 2012

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

scientific article published in November 1996

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

scientific article published on 8 April 2010

Principles of proteomics and its applications in cancer

scientific article published on February 2007

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry

scientific article

Proteasomal degradation of tau protein

scientific article published in October 2002

Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.

scientific article published on 06 September 2012

Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review.

scientific article published on January 2009

Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration

scientific article published on 25 March 2013

Purification of poly-ubiquitinated proteins by S5a-affinity chromatography ⬇️

scientific article published on June 1, 2001

Recent advances in understanding the molecular basis of Paget disease of bone

scientific article published on 26 October 2009

Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

scientific article published on 19 February 2010

Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.

scientific article published on April 2012

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

scientific article published on October 2003

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

scientific article published on 30 January 2014

Second-harmonic generation imaging of collagen in ancient bone

scientific article

Selective isopeptide bond formation: coupling ubiquitin(67-76) with histone 2A(114-128) by use of the transfer active ester condensation technique

scientific article published on 01 June 1999

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

scientific article

Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state

scientific article published in November 2003

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone

scientific article

Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry

scientific article published on 29 May 2015

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains

scientific article published on April 2012

Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone

scientific article

Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

scientific article

Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats.

scientific article published on 24 January 2008

The 6(th) East Midlands Proteomics Workshop supported by the BSPR and BMSS 14 November 2007, Nottingham, UK

scientific article published on 01 May 2008

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

scientific article

The mechanism of growth-promoting effects of prolactin in embryogenesis--links to growth factors

scientific article published on 01 January 1999

The molecular pathogenesis of Paget disease of bone.

scientific article published on October 2007

The ubiquitin proteasome system in human disease

scientific article published on 18 September 2008

The ubiquitin protein catabolic disorders.

scientific article

The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease

scientific article

Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch

scientific article

Ubiquitin superfolds: intrinsic and attachable regulators of cellular activities?

scientific article published on 01 January 1998

Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes

scientific article

Ubiquitin-mediated signalling and Paget's disease of bone

scientific article

Validation of proteomic biomarkers previously found to be differentially expressed in women with polycystic ovary syndrome: a cross-sectional study.

scientific article published on 7 January 2014

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

scientific article published in November 2001

p62 mutations, ubiquitin recognition and Paget's disease of bone

scientific article published on 01 November 2006

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