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List of works by Nico P. Dantuma

A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation

scientific article published on 24 September 2009

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

scientific article

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo

scientific article

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

scientific article

A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy

scientific article

A spider silk-derived solubility domain inhibits nuclear and cytosolic protein aggregation in human cells

scientific article published on 26 May 2022

A transgenic mouse model of the ubiquitin/proteasome system

scientific article published on 20 July 2003

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

scientific article published on 30 July 2009

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

scientific article published in March 2010

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

scientific article published in October 2002

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

scientific article

Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.

scientific article published on 8 March 2017

Biogenesis and processing of the amyloid precursor protein in the early secretory pathway

scientific article published on 19 April 2007

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation ⬇️

scientific article published on 8 February 2011

COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein

scientific article published on 18 September 2006

Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation

scientific article published on 5 January 2015

DDB2 promotes chromatin decondensation at UV-induced DNA damage

scientific article published on 9 April 2012

Disease-associated prion protein oligomers inhibit the 26S proteasome

scientific article published on April 2007

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease

scientific article published on 3 April 2007

Electron microscopic visualization of receptor-mediated endocytosis of Dil-labeled lipoproteins by diaminobenzidine photoconversion

scientific article

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

scientific article published on 15 August 2005

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

scientific article

Fluorescent probes for proteolysis: tools for drug discovery

scientific article published on January 2004

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

scientific article published on 29 September 2008

Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis

scientific article

GFP reporter mouse models of UPS proteolytic function

scientific article published in May 2006

Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin ⬇️

scientific article published on July 19, 2012

Heterochromatin protein 1 is recruited to various types of DNA damage.

scientific article published on May 2009

Illuminating the ubiquitin/proteasome system

scientific article published on 10 February 2010

Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage

scientific article

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

scientific article published on 06 October 2021

Inhibition of ubiquitin/proteasome-dependent proteolysis in Saccharomyces cerevisiae by a Gly-Ala repeat

scientific article

Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates

scientific article published on 16 September 2008

Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates

scientific article published in January 2005

Monitoring the ubiquitin/proteasome system in conformational diseases

scientific article published on October 2003

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

scientific article published on 15 March 2010

Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)

scientific article

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

scientific article published on 20 January 2005

Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants

scientific article published on 9 March 2006

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

scientific article

Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production

scientific article

Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair

scientific article published on 06 January 2021

Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice

scientific article published in October 2007

Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks

scientific article

Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex

scientific article published in March 2012

Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress

scientific article

Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response

scientific article (publication date: 15 November 2014)

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

scientific article

Stabilization of proteasomal substrates by viral repeats

scientific article

Stressing the ubiquitin-proteasome system

scientific article published on 25 July 2009

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

scientific article

The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

scientific article published on 28 January 2013

The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy

scientific article published on 17 October 2019

The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation

scientific article

The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.

scientific article

The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation

scientific article published on 09 August 2017

The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex

scientific article

The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation

scientific article published on 14 February 2009

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

scientific article

The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignancies.

scientific article

Ubiquitin crosstalk connecting cellular processes

scientific article

Ubiquitin versus misfolding: The minimal requirements for inclusion body formation

scientific article published on April 2016

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

scientific journal article

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