List of works - Giovanni Gotte

A domain-swapped RNase A dimer with implications for amyloid formation

scientific article

Antitumor activity and other biological actions of oligomers of ribonuclease A.

scientific article published on 14 April 2003

Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells.

scientific article published on 31 January 2014

Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.

scientific article published on 16 July 2009

Cross-linked trimers of bovine ribonuclease A: activity on double-stranded RNA and antitumor action.

scientific article published on October 1997

Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A.

scientific article

Different susceptibility of the two dimers of ribonuclease A to subtilisin. Implications for their structure.

scientific article

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

scientific article

Elucidation of the ribonuclease a aggregation process mediated by 3D domain swapping: A computational approach reveals possible new multimeric structures

article by Giorgio Cozza et al published January 2008 in Biopolymers

Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer

scientific article published in Journal of Biological Chemistry

Glycosylation and specific deamidation of ribonuclease B affect the formation of three-dimensional domain-swapped oligomers.

scientific article

Increase of RNase AN-terminus Polarity orC-terminus Apolarity Changes the Two Domains' Propensity To Swap and Form the Two Dimeric Conformers of the Protein†

scientific article published on 01 September 2006

Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor

scientific article published on 09 April 2005

Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation

scientific article

Misfolding caused by the pathogenic mutation G47R on the minor allele of alanine:glyoxylate aminotransferase and chaperoning activity of pyridoxine

scientific article published on 3 July 2015

Oligomerization of bovine ribonuclease A: structural and functional features of its multimers

scientific article

Oligomerization of ribonuclease A under reducing conditions

scientific article published on 11 January 2008

Oligomerization of ribonuclease A: two novel three-dimensional domain-swapped tetramers

scientific article

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.

scientific article published on 20 December 2014

Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability

scientific article

RNase A oligomerization through 3D domain swapping is favoured by a residue located far from the swapping domains

scientific article published on 14 July 2011

Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment.

scientific article published in June 2002

Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs

scientific article published on 07 October 2013

Structural properties of trimers and tetramers of ribonuclease A

scientific article

Structural versatility of bovine ribonuclease A. Distinct conformers of trimeric and tetrameric aggregates of the enzyme.

scientific article

Structures of the two 3D domain‐swapped RNase A trimers ⬇️

scientific article published on February 1, 2002

The two dimeric forms of RNase A

scientific article published on 01 January 2000

Thermal aggregation of ribonuclease A. A contribution to the understanding of the role of 3D domain swapping in protein aggregation

scientific article published on 17 January 2003

Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species

scientific article published on 8 November 2005

Two different forms of aggregated dimers of ribonuclease A

scientific article published on 01 July 1998

List of works by Giovanni Gotte

A domain-swapped RNase A dimer with implications for amyloid formation

Antitumor activity and other biological actions of oligomers of ribonuclease A.

Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells.

Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.

Cross-linked trimers of bovine ribonuclease A: activity on double-stranded RNA and antitumor action.

Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A.

Different susceptibility of the two dimers of ribonuclease A to subtilisin. Implications for their structure.

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities

Elucidation of the ribonuclease a aggregation process mediated by 3D domain swapping: A computational approach reveals possible new multimeric structures

Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer

Glycosylation and specific deamidation of ribonuclease B affect the formation of three-dimensional domain-swapped oligomers.

Increase of RNase AN-terminus Polarity orC-terminus Apolarity Changes the Two Domains' Propensity To Swap and Form the Two Dimeric Conformers of the Protein†

Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor

Kinetic analysis provides insight into the mechanism of ribonuclease A oligomer formation

Misfolding caused by the pathogenic mutation G47R on the minor allele of alanine:glyoxylate aminotransferase and chaperoning activity of pyridoxine

Oligomerization of bovine ribonuclease A: structural and functional features of its multimers

Oligomerization of ribonuclease A under reducing conditions

Oligomerization of ribonuclease A: two novel three-dimensional domain-swapped tetramers

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.

Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability

RNase A oligomerization through 3D domain swapping is favoured by a residue located far from the swapping domains

Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment.

Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs

Structural properties of trimers and tetramers of ribonuclease A

Structural versatility of bovine ribonuclease A. Distinct conformers of trimeric and tetrameric aggregates of the enzyme.

Structures of the two 3D domain‐swapped RNase A trimers ⬇️

The two dimeric forms of RNase A

Thermal aggregation of ribonuclease A. A contribution to the understanding of the role of 3D domain swapping in protein aggregation

Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species

Two different forms of aggregated dimers of ribonuclease A