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List of works by István Zupkó

A Comprehensive Assessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound

scientific article published on 16 April 2019

A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"

scientific article published on 20 November 2020

A click approach to novel D-ring-substituted 16α-triazolylestrone derivatives and characterization of their antiproliferative properties

scientific article

A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro

scientific article published on 5 May 2015

A facile 'click' approach to novel 15β-triazolyl-5α-androstane derivatives, and an evaluation of their antiproliferative activities in vitro.

scientific article published on 12 January 2012

A facile access to novel steroidal 17-2'-(1',3',4')-oxadiazoles, and an evaluation of their cytotoxic activities in vitro.

scientific article published on 31 January 2014

A molecular understanding of D-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells

scientific article

A novel murine model for the in vivo study of transdermal drug penetration

article

AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite

scientific article published on 11 November 2020

Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity

scientific article published on 29 August 2017

Alkylbenzoquinones with antiproliferative effect against human cancer cell lines from stem of Ardisia kivuensis

Alpha-adrenergic blockade: a possible mechanism of tocolytic action of certain benzodiazepines in a postpartum rat model in vivo

scientific article

An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.

scientific article published on 22 October 2013

Anti-Cancer Activity of Novel Dihydrotestosterone-Derived Ring A-Condensed Pyrazoles on Androgen Non-Responsive Prostate Cancer Cell Lines ⬇️

scientific article published on 02 May 2019

Anti-proliferative and antibacterial in vitro evaluation of the polyurethane nanostructures incorporating pentacyclic triterpenes

scientific article published on 9 May 2016

Anticancer Properties of Natural Products

scientific article published on 20 May 2015

Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate

scientific article published on 17 February 2014

Antioxidant activity of the fruits and hydrophilic compounds of Physalis alkekengi

scientific article published in January 2009

Antiproliferative Activity of Some Higher Mushrooms from Hungary against Human Cancer Cell Lines.

scientific article published on January 2015

Antiproliferative Effects of Various Furanoacridones Isolated from Ruta graveolens on Human Breast Cancer Cell Lines

scientific article

Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity

scientific article published on 27 July 2018

Antiproliferative activity of Artemisia asiatica extract and its constituents on human tumor cell lines.

scientific article published on 8 October 2014

Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I

scientific article published on 01 December 2007

Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II.

scientific article

Antiproliferative activity of polygonaceae species from the Carpathian Basin against human cancer cell lines.

scientific article

Antiproliferative and Antimicrobial Activities of Selected Bryophytes

scientific article published on 23 June 2018

Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines

scientific article published on 03 August 2018

Antiproliferative constituents of the roots of Conyza canadensis.

scientific article published on 3 February 2011

Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines.

scientific article

Antiproliferative effect of normal and 13-epi-D-homoestrone and their 3-methyl ethers on human reproductive cancer cell lines

scientific article

Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

scientific article

Antitumor activity of alkaloids derived from Amaryllidaceae species.

scientific article published on January 2009

Antitumour properties of acridone alkaloids on a murine lymphoma cell line.

scientific article

Betulin as an antitumor agent tested in vitro on A431, HeLa and MCF7, and as an angiogenic inhibitor in vivo in the CAM assay

scientific article

Betulinic acid in complex with a gamma-cyclodextrin derivative decreases proliferation and in vivo tumor development of non-metastatic and metastatic B164A5 cells

scientific article

Bioactivity-Guided Investigation of the Anti-Inflammatory Activity of Hippophae rhamnoides Fruits.

scientific article

Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria. ⬇️

scientific article published on November 2010

Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.

scientific article published on 17 April 2012

Bioactivity-guided isolation of antiproliferative compounds from the roots of Onopordum acanthium

scientific article published in March 2014

Bioactivity-guided isolation of cytotoxic sesquiterpenes and flavonoids from Anthemis ruthenica

scientific article published on 28 July 2009

Bioactivity-guided study of antiproliferative activities of Salvia extracts

scientific article published on May 1, 2011

Biological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells

scientific article published on June 2009

Botanical Therapeutics (Part II): Antimicrobial and In Vitro Anticancer Activity against MCF7 Human Breast Cancer Cells of Chamomile, Parsley and Celery Alcoholic Extracts

scientific article published on 07 August 2020

Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells ⬇️

scientific article published on 16 November 2018

Chemical and colloidal stability of carboxylated core-shell magnetite nanoparticles designed for biomedical applications.

scientific article published on 12 July 2013

Chlorogenic acid and rutin play a major role in the in vivo anti-diabetic activity of Morus alba leaf extract on type II diabetic rats

scientific article

Chondroitin-Sulfate-A-Coated Magnetite Nanoparticles: Synthesis, Characterization and Testing to Predict Their Colloidal Behavior in Biological Milieu ⬇️

scientific article published on 22 August 2019

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity

Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function

scientific article published on 20 March 2013

Comparison of a specific HPLC determination of toxic aconite alkaloids in processed Radix aconiti with a titration method of total alkaloids

article

Comparison of hexamethylhypericin and tetrabromohypericin to hypericin for their in vivo efficacy as PDT tools

scientific article

Correction to Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8'-Linked 9,10-Phenanthrenequinone Dimers

scientific article published on 11 March 2020

Corrigendum to "Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities" [Steroids 105 (2016) 113-120].

scientific article

Cycloaddition of steroidal cyclic nitrones to C=N dipolarophiles: stereoselective synthesis and antiproliferative effects of oxadiazolidinones in the estrone series

scientific article

Cyclomyrsinane and premyrsinane diterpenes from Euphorbia falcata modulate resistance of cancer cells to doxorubicin

scientific article published in January 2012

Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy

scientific article published on 29 May 2014

Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

scientific article

Cytotoxic phenanthrenes from the rhizomes of Tamus communis

scientific article published on 19 June 2006

Designed Polyelectrolyte Shell on Magnetite Nanocore for Dilution-Resistant Biocompatible Magnetic Fluids

scientific article published on 19 November 2012

Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway

scientific article published on 20 September 2016

Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro

scientific article published on 3 April 2012

Diterpenes from the aerial parts of Salvia candelabrum and their protective effects against lipid peroxidation.

scientific article published in December 2003

Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents.

scientific article

Divergent Synthesis, Antiproliferative and Antimicrobial Studies of 1,3‐Aminoalcohol and 3‐Amino‐1,2‐Diol Based Diaminopyrimidines

scientific article published in 2022

Effect of the isoflavone genistein on tumor size, metastasis potential and melanization in a B16 mouse model of murine melanoma

scientific article published on March 2013

Effects of experimentally induced diabetes mellitus on pharmacologically and electrically elicited myometrial contractility

scientific article

Efficient access to novel androsteno-17-(1',3',4')-oxadiazoles and 17β-(1',3',4')-thiadiazoles via N-substituted hydrazone and N,N'-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro.

scientific article published on 7 May 2015

Efficient approach to androstene-fused arylpyrazolines as potent antiproliferative agents. Experimental and theoretical studies of substituent effects on BF(3)-catalyzed intramolecular [3 + 2] cycloadditions of olefinic phenylhydrazones.

scientific article published in March 2009

Efficient approach to novel 1α-triazolyl-5α-androstane derivatives as potent antiproliferative agents

scientific article published on 6 October 2011

Enhanced stability of polyacrylate-coated magnetite nanoparticles in biorelevant media.

scientific article published on 6 February 2012

First phytochemical investigation of secondary metabolites of Euphorbia davidii Subils. and antiproliferative activity of its extracts.

scientific article published on December 2015

Genistein in 1:1 inclusion complexes with ramified cyclodextrins: theoretical, physicochemical and biological evaluation

scientific article published on 27 January 2014

Germinated and Ungerminated Seeds Extract from Two Lupinus Species: Biological Compounds Characterization and In Vitro and In Vivo Evaluations.

scientific article published on 20 December 2016

Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes

scientific article published on 20 May 2016

Hazai mohafajok fitokémiai és farmakológiai vizsgálata

In vitro anti-diabetic activity and chemical characterization of an apolar fraction of Morus alba leaf water extract.

scientific article

Increase of the uterus-relaxant effect of nifedipine by the Abcg2 efflux protein inhibitor KO134 in the rat in vivo

scientific article published on May 1, 2013

Increasing the amphiphilicity of an estradiol based steroid structure by Barbier-allylation--ring-closing metathesis--dihydroxylation sequence

scientific article

Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens.

scientific article

Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines

scientific article published on 22 November 2018

Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro.

scientific article published on 9 August 2017

Investigation of the Antiproliferative Properties of Natural Sesquiterpenes from Artemisia asiatica and Onopordum acanthium on HL-60 Cells in Vitro.

scientific article

Isobrassinin and its analogues: novel types of antiproliferative agents

scientific article published on 25 September 2006

Isolation and Structure Determination of Antiproliferative Secondary Metabolites from the Potato Earthball Mushroom, Scleroderma bovista (Agaricomycetes)

scientific article published on 01 January 2018

Isolation and quantitative analysis of physalin D in the fruit and calyx of Physalis alkekengi L.

scientific article published in September 2017

Isolation, Structure Determination of Sesquiterpenes from Neurolaena lobata and Their Antiproliferative, Cell Cycle Arrest-Inducing and Anti-Invasive Properties against Human Cervical Tumor Cells

scientific article published in 2021

Jatrophane diterpenes from Euphorbia esula as antiproliferative agents and potent chemosensitizers to overcome multidrug resistance

scientific article

Lewis acid-induced intramolecular access to novel steroidal ring D-condensed arylpyrazolines exerting in vitro cell-growth-inhibitory effects.

scientific article

Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation

scientific article published on 15 November 2014

Mechanism of antiproliferative action of a new d-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility

scientific article published on 27 June 2016

Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro

scientific article published on 3 May 2016

Microwave-assisted synthesis of biologically relevant steroidal 17--pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence

scientific article published on 08 October 2018

Monitoring the antioxidant activity of extracts originated from various Serratula species and isolation of flavonoids from Serratula coronata

scientific article

New iridoids from the roots of Valeriana dioscoridis Sm

scientific article published on 21 August 2018

Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam.

scientific article published on 12 December 2017

Oxidized Juncuenin B Analogues with Increased Antiproliferative Activity on Human Adherent Cell Lines: Semisynthesis and Biological Evaluation

scientific article published on 16 October 2020

Pd-Catalyzed Suzuki-Miyaura couplings and evaluation of 13α-estrone derivatives as potential anticancer agents

scientific article published on 15 September 2020

Phenanthrenes and a dihydrophenanthrene from Tamus communis and their cytotoxic activity

scientific article published on 12 December 2006

Phenanthrenes from Jacq. with Promising Antiproliferative and Anti-HSV-2 Activities

scientific article published on 20 August 2018

Photostability Testing of a Third-Generation Retinoid-Tazarotene in the Presence of UV Absorbers

scientific article published on 22 September 2020

Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line

scientific article published on 20 December 2018

Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8'-Linked 9,10-Phenanthrenequinone Dimers

scientific article published on 20 February 2020

Polyurethane Microstructures--a Good or Bad in vitro Partner for the Isoflavone Genistein?

scientific article published on June 2015

Possible role of fat tissue in the pharmacokinetics of Dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides after oral administration of Echinacea angustifolia extract in rats

scientific article published in June 2014

Preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation

scientific article

Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling

scientific article published on 12 June 2020

Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots

scientific article published on 28 October 2008

Sesquiterpene Lactones and Flavonoids from Psephellus pyrrhoblepharus with Antiproliferative Activity on Human Gynecological Cancer Cell Lines

scientific article published on 30 August 2019

Sesquiterpenes from Neurolaena lobata and their antiproliferative and anti-inflammatory activities.

scientific article published on 29 January 2014

Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter.

scientific article published on 30 May 2012

Squalenoylated Nanoparticle Pro-Drugs of Adjuvant Antitumor 11α-Hydroxyecdysteroid 2,3-Acetonides Act as Cytoprotective Agents Against Doxorubicin and Paclitaxel

scientific article published on 11 September 2020

Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities

scientific article published on 11 December 2015

Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities

scientific article published on 16 September 2019

Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpen Aminodiols

scientific article published on 26 December 2019

Stereoselective Synthesis, Synthetic and Pharmacological Application of Monoterpene-Based 1,2,4- and 1,3,4-Oxadiazoles

scientific article published on 28 December 2017

Stereoselective synthesis and cytoselective toxicity of monoterpene-fused 2-imino-1,3-thiazines.

scientific article

Stereoselective synthesis of new type of estradiol hybrid molecules and their antiproliferative activities

scientific article published on 11 May 2019

Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities

scientific article published in March 2018

Study of in vitro antimicrobial and antiproliferative activities of selected Saharan plants

scientific article published on December 2015

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation.

scientific article

Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects

scientific article published on 6 November 2013

Syntheses and antiproliferative effects of D-homo- and D-secoestrones

scientific article

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates.

scientific article published on 10 September 2016

Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores

scientific article published on 24 February 2020

Synthesis and In Vitro Antitumor Activity of Naringenin Oxime and Oxime Ether Derivatives. ⬇️

scientific article published on 2 May 2019

Synthesis and Transformation of (-)-Isopulegol-Based Chiral -Aminolactones and -Aminoamides ⬇️

scientific article published on 08 November 2018

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

scientific article published on 20 October 2009

Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays

scientific article

Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents

scientific article published on 2 June 2016

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives

scientific article published on 01 December 2021

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative.

scientific article published on 12 May 2016

Synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives.

scientific article published on 9 June 2011

Synthesis and in vitro antiproliferative evaluation of d-secooxime derivatives of 13β- and 13α-estrone

scientific article published on 20 August 2014

Synthesis and in vitro investigation of potential antiproliferative monosaccharide-d-secoestrone bioconjugates

scientific article

Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds

scientific article published on 11 September 2015

Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro.

scientific article

Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer

scientific article published on 19 October 2018

Synthesis of D-ring-substituted (5'R)- and (5'S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities

scientific article

Synthesis of antiproliferative 13α-d-homoestrones via Lewis acid-promoted one-pot Prins-Ritter reactions of d-secosteroidal δ-alkenyl-aldehydes

scientific article published on 22 July 2015

Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation

scientific article published on 21 March 2015

Synthesis of novel 17-(4'-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17α-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents depending on the substitution pattern of the heteroring.

scientific article

Synthesis of novel 17-(5'-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro

scientific article

Synthesis of novel steroidal 16-spiroisoxazolines by 1,3-dipolar cycloaddition, and an evaluation of their antiproliferative activities in vitro

scientific article published on 2 April 2014

Synthesis of novel steroidal 17α-triazolyl derivatives via Cu(I)-catalyzed azide-alkyne cycloaddition, and an evaluation of their cytotoxic activity in vitro

scientific article published on 10 May 2011

Synthesis of trans-16-triazolyl-13α-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities

scientific article

Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series.

scientific article published on 18 May 2012

The antiplasmodial activity of isolates from Ajuga remota

scientific article

The effects of alpha-methyldopa on myometrial noradrenaline release and myometrial contractility in rat

scientific article published on 01 January 2007

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

scientific article published on 26 June 2015

Xanthanolides with antitumour activity from Xanthium italicum

scientific article

[Thermoanalytical investigation of rat myometrium during gestation]

scientific article published on 01 January 2009

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