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List of works by Rene van Lier

5(th) International Workshop on CMV and Immunosenescence - A shadow of cytomegalovirus infection on immunological memory.

scientific article published in April 2015

A Novel Role for CD55 in Granulocyte Homeostasis and Anti-Bacterial Host Defense ⬇️

scientific article published on October 3, 2011

A fingerprint left by cytomegalovirus infection in the human T cell compartment.

scientific article published on 03 December 2007

A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity

scientific article published on 9 August 2011

A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis.

scientific article

A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells

scientific article published on 12 February 2013

AICL: a new activation-induced antigen encoded by the human NK gene complex

scientific article

Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis

scientific article published on 19 June 2013

Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella

scientific article published on 15 December 2004

Activation and expansion of tumour-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies

scientific article published on 01 January 1990

Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells.

scientific article

Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands

scientific article published in January 2008

Alloantigen-induced regulatory CD8+CD103+ T cells.

scientific article published on 24 September 2008

Alteration of B-cell antigen receptor signaling by CD19 co-ligation. A study with bispecific antibodies.

scientific article published on September 1996

Analysis of CD27 surface expression on T cell subsets in MS patients and control individuals

scientific article published in January 1995

Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells

scientific article published on 26 July 2012

Anti-HLA-class II monoclonal antibodies inhibit polyclonal B cell differentiationin vitro at the accessory cell level

scientific article published in 1987

Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones.

scientific article

Autologous cytomegalovirus-specific T cells as effector cells in immunotherapy of B cell chronic lymphocytic leukaemia

scientific article published in August 2004

B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function

scientific article published on 6 August 2010

B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation

scientific article published in November 1994

BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation.

scientific article published on 5 December 2011

Baseline T cell reactivity in multiple sclerosis is correlated to efficacy of interferon-beta.

scientific article

Better safe than sorry: TOB1 employs multiple parallel regulatory pathways to keep Th17 cells quiet

scientific article published on 19 February 2014

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans

scientific journal article

Blood and beyond: properties of circulating and tissue-resident human virus-specific αβ CD8(+) T cells

scientific article published on 19 February 2014

CD20-induced B cell death can bypass mitochondria and caspase activation.

scientific article

CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome

scientific article published on 11 September 2006

CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.

scientific article published on 10 April 2013

CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth

scientific article

CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.

scientific article published on 4 June 2007

CD28 and T-cell activation

scientific article published in April 1995

CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack.

scientific article published in November 2004

CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101

scientific article published on 26 September 2011

CD40 stimulation sensitizes CLL cells to rituximab-induced cell death ⬇️

scientific article published on March 15, 2011

CD70 expression on T-cell subpopulations: study of normal individuals and patients with chronic immune activation

scientific article published in February 1997

CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.

scientific article published on 26 March 2012

CD97 neutralisation increases resistance to collagen-induced arthritis in mice

scientific article

CMV and Immunosenescence: from basics to clinics

scientific article published on 31 October 2012

CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia.

scientific article published on 18 November 2013

CXCR5+CD4+ follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity.

scientific article published on 29 November 2013

Cellular immune responses during high-dose interferon-alpha induction therapy for hepatitis C virus infection.

scientific article published on March 2009

Changes in the composition of circulating CD8+ T cell subsets during acute epstein-barr and human immunodeficiency virus infections in humans

scientific article published on 24 July 2000

Characteristics of alloreactive T cells measured before renal transplantation.

scientific article published in May 2012

Characteristics of differentiated CD8(+) and CD4 (+) T cells present in the human brain.

scientific article

Characterization of CD4+Memory T Cell Responses Directed against Common Respiratory Pathogens in Peripheral Blood and Lung

scientific article published in June 2007

Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97 ⬇️

scientific article published on May 1, 1998

Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis

scientific article published in December 2002

Children with chronic renal failure have reduced numbers of memory B cells

scientific article published in September 2004

Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation

scientific article

Circulating lymphocyte subsets in different clinical situations after renal transplantation

scientific article published in June 2012

Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.

scientific article

Common variable immunodeficiency and hemophagocytic features associated with a FAS gene mutation

scientific article published in June 2011

Comparison of the response to T-cell activation by integrated HIV-1 and HTLV-1 LTR-lacZ vectors.

scientific article published on June 1995

Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion

scientific journal article

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

scientific article published in April 2010

Control of lymphocyte function through CD27–CD70 interactions

scientific article published in December 1998

Cross-reactivity of cytomegalovirus-specific CD8+ T cells to allo-major histocompatibility complex class I molecules

scientific article published in June 2004

Culture of tumour-infiltrating lymphocytes from melanoma and colon carcinoma: Removal of tumour cells does not affect tumour-specificity

scientific article published in September 1995

Cutting edge: virus selectively primes human langerhans cells for CD70 expression promoting CD8+ T cell responses.

scientific article

Cytokine producing CD8+ T cells are correlated to MRI features of tissue destruction in MS.

scientific article

Cytomegalovirus infection reduces telomere length of the circulating T cell pool.

scientific article published on 22 February 2010

Cytomegalovirus-induced effector T cells cause endothelial cell damage.

scientific article published on 7 March 2012

Cytotoxic human CD4(+) T cells

scientific article published on 24 April 2008

Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years.

scientific article

Defect of Interleukin-2 Production and T Cell Proliferation in Atopic Patients: Restoring Ability of the CD28-Mediated Activation Pathway

scientific article published in May 1993

Detection of allospecific T cells by intracellular cytokine staining and flowcytometry.

scientific article

Determination of helper T-cell precursor frequencies against non-haemopoietic cells: comparison of co-stimulation provided by anti-CD28 antibody versus the cellular ligand B7-1

scientific article published in August 2000

Development of virus-specific CD4+ T cells on reexposure to Varicella-Zoster virus

scientific article published on 26 May 2004

Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone

scientific article published in 1995

Differentiation of CMV-specific CD8POS T lymphocytes in primary CMV infection after renal transplantation

scientific article published in November 2001

Differentiation of Human Alloreactive CD4+ and CD8+ T Cells In Vitro

scientific article published in September 2004

Differentiation of human alloreactive CD8(+) T cells in vitro

scientific article published in March 2002

Effects of CD25 monoclonal antibody on proliferative and effector functions of alloactivated human T cells in vitro

scientific article published in March 2004

Efficient expansion of tumor-infiltrating lymphocytes from solid tumors by stimulation with combined CD3 and CD28 monoclonal antibodies

scientific article published in September 1993

Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients

scientific article published in December 1991

Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.

scientific article

Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice

scientific article published in February 2013

Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia.

scientific article

Everolimus-treated renal transplant recipients have a more robust CMV-specific CD8+ T-cell response compared with cyclosporine- or mycophenolate-treated patients

scientific article published in January 2013

Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones

scientific article

Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals

scientific article

Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division

scientific article published in July 1999

Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia

scientific article published on 10 April 2003

Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia.

scientific article published on 19 April 2012

Expression of the Activation Antigen CD27 in Rheumatoid Arthritis

scientific article published in August 1996

Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis

scientific article (publication date: November 2002)

Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells

scientific article

Faces and phases of human CD8 T-cell development.

scientific article

Function of CD27 in helper T cell differentiation

scientific article published in May 2011

Functional defects in peripheral blood T cells of multiple sclerosis patients. Diminished in vitro responsiveness in accessory cell dependent activation systems

scientific article published in July 1994

Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation

scientific article published on 18 April 2005

GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo.

scientific article

Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity?

scientific article

Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation.

scientific article

Human Cytomegalovirus Induces Systemic Immune Activation Characterized by a Type 1 Cytokine Signature

scientific article published in September 2010

Human T-cell memory consists mainly of unexpanded clones.

scientific article published on 16 July 2010

Human virus-specific CD8+ T cells: diversity specialists.

scientific article published on June 2006

Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes.

scientific article published on 29 December 2011

IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro

scientific article published on 12 June 2003

IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells.

scientific article published on 9 June 2005

Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70.

scientific article published in May 1996

Identification of two distinct phosphoproteins as components of the human B cell antigen receptor complex

scientific article published in December 1990

Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations

scientific article published on 18 April 2011

Immune activation modulates hematopoiesis through interactions between CD27 and CD70

scientific article published on 20 February 2005

Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence.

scientific article

Increased Numbers ofin vivoActivated T cells in Patients with Recent Onset Insulin-dependent Diabetes Mellitus

scientific article published in December 1996

Induction and maintenance of CD8+ T cells specific for persistent viruses.

scientific article published on January 2007

Infection history determines the differentiation state of human CD8+ T cells

scientific article

Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity

scientific article published in September 2001

Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease

scientific article published on 01 June 2001

Kawasaki Disease: A Maturational Defect in Immune Responsiveness

scientific article published in December 1999

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions

scientific article published on 9 December 2002

Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands

scientific article published on 12 November 2020

Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex

scientific article published in November 1993

Lymphocyte costimulation: multiple pathways, multiple functions?

scientific article published on March 1995

Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1.

scientific article published in October 2012

Monitoring the T-cell receptor repertoire at single-clone resolution.

scientific article

Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation

scientific journal article

New advances in CMV and immunosenescence

scientific article

News and EFIS ⬇️

scientific article published on April 1, 2012

Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription

scientific article published in January 1991

Persistent detection of varicella-zoster virus DNA in a previously healthy child after severe chickenpox

scientific article

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells ⬇️

scientific article published on November 3, 1997

Phenotypic and functional characterization of circulating polyomavirus BK VP1-specific CD8+ T cells in healthy adults.

scientific article published on 17 July 2013

Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications

scientific article published in January 2006

Primary human keratinocytes as targets in predicting acute graft-versus-host disease following HLA-identical bone marrow transplantation

scientific article published in December 2000

Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease.

scientific article published on 31 October 2002

Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology.

scientific article published on 31 December 2012

Prognostic value of Th1/Th2 ratio in rheumatoid arthritis

scientific article published in The Lancet

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells.

scientific article

Properties of CD4(+) T cells in human cytomegalovirus infection

scientific article

Properties of murine (CD8+)CD27- T cells

scientific article published in November 2005

Protective CD8 T cell memory is impaired during chronic CD70-driven costimulation.

scientific article published in May 2009

Quantitation of interferon gamma- and interleukin-4-producing T cells in synovial fluid and peripheral blood of arthritis patients

scientific article published in March 1999

Quantitation of soluble CD27, a T-cell activation antigen, and soluble interleukin-2 receptor in serum from patients with psoriasis

scientific article published in December 1991

Rapamycin Enhances the Number of Alloantigen-Induced Human CD103+CD8+ Regulatory T Cells In Vitro

scientific article published in April 2007

Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells

scientific article published in February 2006

Rapid T cell repopulation after rabbit anti-thymocyte globulin (rATG) treatment is driven mainly by cytomegalovirus

scientific article published in September 2012

Recombinant Interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells

scientific article published in July 1996

Redirection of CMV-specific CTL towards B-CLL via CD20-targeted HLA/CMV complexes

scientific article published on 23 March 2006

Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Respiratory syncytial virus-specific CD8+ memory T cell responses in elderly persons

scientific article

Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung.

scientific article published on November 2005

Selective loss of T cell functions in different stages of HIV infection. Early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS.

scientific article published in May 1990

Sevenspan transmembrane molecules: novel receptors involved in leukocyte adhesion.

scientific article published on December 1996

Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55.

scientific article published on 27 February 2013

Skewed maturation of virus-specific CTLs?

scientific article published in March 2002

Specific expression of GPR56 by human cytotoxic lymphocytes.

scientific article

Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients

scientific article

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.

scientific article published on 13 July 2006

Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily

scientific article

The Bug in MyD88 Dependency

scientific article published in October 2006

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

scientific article (publication date: June 2006)

The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants

scientific article published on 14 July 2011

The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense

scientific article (publication date: 15 January 2004)

The interaction between cytomegalovirus and the human immune system

scientific article published on 16 October 2014

The price of the CD27-CD70 costimulatory axis: you can't have it all.

scientific article published on 23 October 2006

The pyrimidin analogue cyclopentenyl cytosine induces alloantigen-specific non-responsiveness of human T lymphocytes

scientific article published on 6 December 2007

The role of lymphocyte subsets and adhesion molecules in T cell-dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies

scientific article published on 01 July 1995

Tissue distribution of the human CD97 EGF-TM7 receptor

scientific article (publication date: April 2001)

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

scientific article published on 13 July 2020

Tissue-resident memory T cells at the center of immunity to solid tumors

scientific article published on 18 May 2018

Treatment with monoclonal anti-tumor necrosis factor alpha antibody results in an accumulation of Th1 CD4+ T cells in the peripheral blood of patients with rheumatoid arthritis

scientific article published in October 1999

Tumor immunity requires border patrol to fight the enemy within

scientific article

Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-γ-mediated signaling

scientific article published in June 2003

Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection.

scientific article

Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells.

scientific article

With(out) a little help from my friends: An IL‐12/CD40L‐mediated feed‐forward loop between CD8+T cells and DCs ⬇️

scientific article published on June 1, 2013

Withdrawal symptoms on display: Bcl-2 members under investigation

scientific article published in January 2007

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