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List of works by Morten Agertoug Nielsen

4-Aminoquinoline derivatives: Synthesis, in vitro and in vivo antiplasmodial activity against chloroquine-resistant parasites

scientific article published on 23 June 2016

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA.

scientific article published on 23 November 2015

A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

scientific article published on 15 July 2020

A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine

scholarly article by Christoph M Janitzek et al published 27 March 2019 in Scientific Reports

A sub-family of common and highly conserved Plasmodium falciparum var genes.

scientific article

Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria

scientific article published on 26 May 2016

An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria

scientific article

Bacterial superglue enables easy development of efficient virus-like particle based vaccines

scientific article

Bacterial superglue generates a full-length circumsporozoite protein virus-like particle vaccine capable of inducing high and durable antibody responses

scientific article

Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes

scientific article

Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration

scientific article published on 20 December 2016

Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?

scientific article published on 26 February 2010

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

scientific article published on 12 January 2021

Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites

scientific article published on 12 June 2007

Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites

scientific article published on 24 March 2009

Clinical development of a VAR2CSA-based placental malaria vaccine PAMVAC: Quantifying vaccine antigen-specific memory B & T cell activity in Beninese primigravidae

scientific article published on 17 May 2017

Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

scientific article published on 17 September 2016

Comparison of functional assays used in the clinical development of a placental malaria vaccine

scientific article published on 21 December 2016

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA

scientific article published in 2019

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

scientific article published on 19 May 2021

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced

scientific article

Determinants of variant surface antigen antibody response in severe Plasmodium falciparum malaria in an area of low and unstable malaria transmission

scientific article published in March 2006

Development of a Drosophila S2 insect-cell based placental malaria vaccine production process.

scientific article published on 4 December 2013

Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania

scientific article published on 4 February 2008

Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA.

scientific article

Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

scientific article

Differential induction of immunoglobulin G to Plasmodium falciparum variant surface antigens during the transmission season in Daraweesh, Sudan

scientific article published on 27 June 2005

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration

scientific article

Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart

scientific article published on 14 September 2015

Evidence for the involvement of VAR2CSA in pregnancy-associated malaria

scientific article

First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria

scientific article published on 01 October 2019

Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

scientific article

Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens

scientific article

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

scientific article

High-Throughput Testing of Antibody-Dependent Binding Inhibition of Placental Malaria Parasites

scientific article published on January 2015

Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA

scientific article published on 14 December 2006

Identification and characterization of B-cell epitopes in the DBL4ε domain of VAR2CSA

scientific article

Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.

scientific article published on 22 September 2015

Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA

scientific article

Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display

scientific article published on 31 May 2017

In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African children

scientific article published in August 2003

Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA.

scientific article published on 23 March 2009

Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparum Variant Surface Antigens ⬇️

scientific article published on November 1, 2001

Mannose-Binding Lectin Is a Disease Modifier in Clinical Malaria and May Function as Opsonin for Plasmodium falciparum- Infected Erythrocytes

scientific article published in November 2003

Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes

scientific article published on September 2003

Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro

scientific article published on 27 August 2012

Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria

scientific article published on 3 December 2012

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates

scientific article

Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen

scientific article published on 25 January 2017

Persistent Plasmodium falciparum Infection in Women With an Intent to Become Pregnant as a Risk Factor for Pregnancy-associated Malaria

scientific article published on 4 May 2018

Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum.

scientific article

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

scientific article (publication date: August 2016)

Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

scientific article

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.

scientific article

Plasmodium falciparum infection early in pregnancy has profound consequences for foetal growth

scientific article published on 6 October 2017

Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression

scientific article

Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity

scientific article published in April 2002

Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin

scientific article published on 14 March 2007

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women

scientific article

Pre-clinical and clinical development of the first placental malaria vaccine

scientific article

Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines

scientific article published on 30 December 2008

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

scientific article published on May 2015

Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies

scientific article

Severe malaria is associated with parasite binding to endothelial protein C receptor

scientific article

Specificity and cross-reactivity of Plasmodium falciparum variant surface antigen-specific antibody responses

scientific article published on April 2003

Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.

scientific article

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA

scientific article

Structure function analysis of P. falciparum VAR2CSA.

scientific article

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

scientific article published on October 2015

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine

scientific article

The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A.

scientific article published in October 2011

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

scientific article published in Nature Communications

The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains

scientific article

The effect of adjuvants on the immune response induced by a DBL4ɛ-ID4 VAR2CSA based Plasmodium falciparum vaccine against placental malaria.

scientific article published on 26 November 2011

Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.

scientific article published on 21 January 2014

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

scientific article

Virus-like particle display of HER2 induces potent anti-cancer responses

scientific article published on 5 January 2018

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