List of works - Kyosuke Takeshita

A novel cholesterol absorption inhibitor, ezetimibe, decreases adipose-derived and vascular PAI-1 expression in vivo.

scientific article published on 31 May 2009

Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy

scientific article published on 19 August 2016

Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly.

scientific article

Angiotensin II receptor blocker ameliorates stress-induced adipose tissue inflammation and insulin resistance

scientific article

Angiotensin receptor blocker improves a stress-induced prothrombotic state in a murine model

scientific article published on 01 April 2016

Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice

scientific article

Ankle brachial pressure index but not brachial-ankle pulse wave velocity is a strong predictor of systemic atherosclerotic morbidity and mortality in patients on maintenance hemodialysis

scientific article published on 01 October 2011

Anxiety and Depression among Hypertensive Outpatients in Afghanistan: A Cross-Sectional Study in Andkhoy City

scientific article published on 01 August 2018

Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study

scientific article published on 07 June 2019

Assessment of left ventricular diastolic function during trastuzumab treatment in patients with HER2-positive breast cancer.

scientific article

Association between Helicobacter pylori Infection and Cardiovascular Risk Factors among Patients in the Northern Part of Afghanistan: a Cross-Sectional Study in Andkhoy City

scientific article published on 25 April 2018

Association between cardiopulmonary exercise and dobutamine stress testing in ambulatory patients with idiopathic dilated cardiomyopathy: a comparison with peak VO₂ and VE/VCO₂ slope

scientific article published on 01 January 2013

Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy

scientific article published on 26 October 2012

Association of cardiorespiratory fitness with characteristics of coronary plaque: assessment using integrated backscatter intravascular ultrasound and optical coherence tomography.

scientific article

Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men.

scientific article

Associations between proteinuria and cardiovascular risk factors among hypertensive patients in Andkhoy, Afghanistan.

scientific article published on December 2016

Asymptomatic left atrial thrombus in a dialysis-dependent patient free of thrombogenic abnormalities

scientific article published on 04 September 2014

Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients With Hypertrophic Cardiomyopathy

scientific article published on 23 December 2016

Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.

scientific article published on July 2010

Cardiopulmonary Exercise Testing as a Tool for Diagnosing Pulmonary Hypertension in Patients with Dilated Cardiomyopathy.

scientific article published in February 2016

Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: an endothelin receptor antagonist improves the peak PETCO2

scientific article published on 15 March 2014

Carotidynia with carotid arterial thrombosis

scientific article published on 01 December 2012

Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.

scientific article

Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway.

scientific article published on 30 June 2016

Cathepsin S activity controls ischemia-induced neovascularization in mice.

scientific article

Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and protease‑activated receptor 2 in a murine model

scientific article published on 25 April 2019

Circulating omentin is associated with coronary artery disease in men.

scientific article

Circulatory power and ventilatory power over time under goal-oriented sequential combination therapy for pulmonary arterial hypertension

scientific article

Coincidental finding of isolated congenital double-orifice mitral valve in two adult patients

scientific article published on 06 January 2011

Corrigendum to "The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy" [J. Cardiol. 71 (2018) 284-290]

scientific article published on 02 March 2018

Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

scientific article published on 7 December 2006

Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt

scientific article

Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions

scientific article

Diagnostic usefulness of postexercise systolic blood pressure response for detection of coronary artery disease in patients with echocardiographic left ventricular hypertrophy.

scientific article published in May 2004

Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress.

scientific article published on 14 July 2017

Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model

scientific article published on 3 August 2016

Does angiotensin receptor blockade ameliorate the prothrombotic tendency in hypertensive patients with atrial fibrillation? Breaking the vicious cycle

scientific article published on 13 March 2014

Effects of bosentan on peripheral endothelial function in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension

scientific article published on June 2016

Efficacy and safety of radiofrequency catheter ablation for atrial fibrillation in chronic hemodialysis patients.

scientific article published on 28 October 2013

Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method

scientific article published on 01 January 2003

Essential role of endothelial Notch1 in angiogenesis

scientific journal article

Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice

scientific article published in January 2006

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

scientific article published on 2 August 2016

Identification of a novel missense mutation (563G>a) in the ABO gene associated with a Bel phenotype

scientific article

Impact of Admission Anemia on Coronary Microcirculation and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

scientific article published on 24 June 2015

Impact of Plaque Burden in the Left Main Coronary Artery Determined by Intravascular Ultrasound on Cardiovascular Events in a Japanese Population Undergoing Percutaneous Coronary Intervention ⬇️

scientific article published on November 8, 2011

Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with establis

scientific article published on August 2010

Impact of airflow limitation on carotid atherosclerosis in coronary artery disease patients.

scientific article published on 17 March 2015

Impact of metabolic syndrome on various aspects of microcirculation and major adverse cardiac events in patients with ST-segment elevation myocardial infarction

scientific article published on 23 May 2012

Impact of the low- to high-density lipoprotein cholesterol ratio on composition of angiographically ambiguous left main coronary artery plaque

scientific article published on 04 June 2011

In vivo tracking of transplanted macrophages with near infrared fluorescent dye reveals temporal distribution and specific homing in the liver that can be perturbed by clodronate liposomes

scientific article published on 10 December 2020

Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.

scientific article published on 16 May 2017

Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.

scientific article

Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse

scientific article published on 01 December 2002

Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells

scientific article published in November 2017

Indoxyl sulfate, a uremic toxin, and carotid intima-media thickness in patients with coronary artery disease.

scientific article published on 11 July 2012

Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells

scientific article

Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.

scientific article

Left ventricular hypertrophy and proteinuria in patients with essential hypertension in Andkhoy, Afghanistan.

scientific article published in May 2018

Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency.

scientific article

Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib

scientific article

Measurements of renal shear wave velocities in chronic kidney disease patients

scientific article published in January 2017

Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker.

scientific article published on 16 December 2013

Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice

scientific article published on 5 August 2017

Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy

scientific article published on 18 March 2017

Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice

scientific article published on 22 February 2010

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

scientific article

Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice

scientific article published on 02 October 2006

Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.

scientific article published on 07 February 2011

Plasma indoxyl sulfate and estimated glomerular filtration rate

scientific article published on 11 August 2014

Plasminogen activator inhibitor-1 in aging

scientific article

Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals.

scientific article

Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction

scientific article published on 06 August 2011

Possible involvement of Notch signaling in the pathogenesis of Buerger's disease

scientific article published on 19 April 2013

Predictive value of heart rate recovery after exercise testing in addition to brain natriuretic peptide levels in ambulatory patients with nonischemic dilated cardiomyopathy.

scientific article published on 13 August 2012

Prognostic impact of combined late gadolinium enhancement on cardiovascular magnetic resonance and peak oxygen consumption in ambulatory patients with nonischemic dilated cardiomyopathy.

scientific article

Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone

scientific article

Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction

scientific article published on 8 December 2012

Relationship of myocardial fibrosis to left ventricular and mitochondrial function in nonischemic dilated cardiomyopathy--a comparison of focal and interstitial fibrosis.

scientific article published in August 2013

Renin inhibition reduces atherosclerotic plaque neovessel formation and regresses advanced atherosclerotic plaques

scientific article published on 30 October 2014

Requirement of Rac1 in the development of cardiac hypertrophy.

scholarly article

Sharpening the Focus: Acupuncture Interrupts the Brain-Gut Vicious Cycle Underlying Functional Dyspepsia

scientific article published on 05 February 2020

Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression

scientific article published on 22 March 2004

Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers

scientific article

Sokolow-Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy

scientific article published on 03 February 2017

Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1.

scientific article published on 6 March 2012

Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo

scientific article

Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice

scientific journal article

The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy

scientific article published on 20 October 2017

The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil

scientific article published in December 2002

Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease

scientific article published on 18 October 2017

Usefulness of serum cardiac troponins T and I to predict cardiac molecular changes and cardiac damage in patients with hypertrophic cardiomyopathy

scientific article published in January 2013

Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice

scientific article

[Assessment of cardiac contractile reserve].

scientific article

gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice.

scientific article published on 5 April 2009

List of works by Kyosuke Takeshita

A novel cholesterol absorption inhibitor, ezetimibe, decreases adipose-derived and vascular PAI-1 expression in vivo.

Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy

Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly.

Angiotensin II receptor blocker ameliorates stress-induced adipose tissue inflammation and insulin resistance

Angiotensin receptor blocker improves a stress-induced prothrombotic state in a murine model

Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice

Ankle brachial pressure index but not brachial-ankle pulse wave velocity is a strong predictor of systemic atherosclerotic morbidity and mortality in patients on maintenance hemodialysis

Anxiety and Depression among Hypertensive Outpatients in Afghanistan: A Cross-Sectional Study in Andkhoy City

Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study

Assessment of left ventricular diastolic function during trastuzumab treatment in patients with HER2-positive breast cancer.

Association between Helicobacter pylori Infection and Cardiovascular Risk Factors among Patients in the Northern Part of Afghanistan: a Cross-Sectional Study in Andkhoy City

Association between cardiopulmonary exercise and dobutamine stress testing in ambulatory patients with idiopathic dilated cardiomyopathy: a comparison with peak VO₂ and VE/VCO₂ slope

Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy

Association of cardiorespiratory fitness with characteristics of coronary plaque: assessment using integrated backscatter intravascular ultrasound and optical coherence tomography.

Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men.

Associations between proteinuria and cardiovascular risk factors among hypertensive patients in Andkhoy, Afghanistan.

Asymptomatic left atrial thrombus in a dialysis-dependent patient free of thrombogenic abnormalities

Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients With Hypertrophic Cardiomyopathy

Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.

Cardiopulmonary Exercise Testing as a Tool for Diagnosing Pulmonary Hypertension in Patients with Dilated Cardiomyopathy.

Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: an endothelin receptor antagonist improves the peak PETCO2

Carotidynia with carotid arterial thrombosis

Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.

Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway.

Cathepsin S activity controls ischemia-induced neovascularization in mice.

Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and protease‑activated receptor 2 in a murine model

Circulating omentin is associated with coronary artery disease in men.

Circulatory power and ventilatory power over time under goal-oriented sequential combination therapy for pulmonary arterial hypertension

Coincidental finding of isolated congenital double-orifice mitral valve in two adult patients

Corrigendum to "The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy" [J. Cardiol. 71 (2018) 284-290]

Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt

Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions

Diagnostic usefulness of postexercise systolic blood pressure response for detection of coronary artery disease in patients with echocardiographic left ventricular hypertrophy.

Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress.

Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model

Does angiotensin receptor blockade ameliorate the prothrombotic tendency in hypertensive patients with atrial fibrillation? Breaking the vicious cycle

Effects of bosentan on peripheral endothelial function in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension

Efficacy and safety of radiofrequency catheter ablation for atrial fibrillation in chronic hemodialysis patients.

Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method

Essential role of endothelial Notch1 in angiogenesis

Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Identification of a novel missense mutation (563G>a) in the ABO gene associated with a Bel phenotype

Impact of Admission Anemia on Coronary Microcirculation and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Impact of Plaque Burden in the Left Main Coronary Artery Determined by Intravascular Ultrasound on Cardiovascular Events in a Japanese Population Undergoing Percutaneous Coronary Intervention ⬇️

Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with establis

Impact of airflow limitation on carotid atherosclerosis in coronary artery disease patients.

Impact of metabolic syndrome on various aspects of microcirculation and major adverse cardiac events in patients with ST-segment elevation myocardial infarction

Impact of the low- to high-density lipoprotein cholesterol ratio on composition of angiographically ambiguous left main coronary artery plaque

In vivo tracking of transplanted macrophages with near infrared fluorescent dye reveals temporal distribution and specific homing in the liver that can be perturbed by clodronate liposomes

Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.

Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.

Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse

Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells

Indoxyl sulfate, a uremic toxin, and carotid intima-media thickness in patients with coronary artery disease.

Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells

Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.

Left ventricular hypertrophy and proteinuria in patients with essential hypertension in Andkhoy, Afghanistan.

Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency.

Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib

Measurements of renal shear wave velocities in chronic kidney disease patients

Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker.

Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice

Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy

Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice

Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.

Plasma indoxyl sulfate and estimated glomerular filtration rate

Plasminogen activator inhibitor-1 in aging

Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals.

Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction

Possible involvement of Notch signaling in the pathogenesis of Buerger's disease

Predictive value of heart rate recovery after exercise testing in addition to brain natriuretic peptide levels in ambulatory patients with nonischemic dilated cardiomyopathy.

Prognostic impact of combined late gadolinium enhancement on cardiovascular magnetic resonance and peak oxygen consumption in ambulatory patients with nonischemic dilated cardiomyopathy.

Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone

Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction

Relationship of myocardial fibrosis to left ventricular and mitochondrial function in nonischemic dilated cardiomyopathy--a comparison of focal and interstitial fibrosis.