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List of works by Philip Seeman

"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

scientific article

"Extended" Antipsychotic Dosing

scientific article published on 01 December 2005

"Extended" antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial

scientific article published on 07 September 2010

Alcohol-withdrawn animals have a prolonged increase in dopamine D2high receptors, reversed by general anesthesia: relation to relapse?

scientific article published in May 2004

Alzheimer's disease: β‐amyloid plaque formation in human brain ⬇️

scientific article published on December 1, 2011

Amphetamine sensitization elevates CaMKIIbeta mRNA.

scientific article published in October 2007

Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges

scientific article published in December 2002

Anesthetics inhibit high-affinity states of dopamine D2 and other G-linked receptors

scientific article published in October 2003

Antiparkinson concentrations of pramipexole and PHNO occupy dopamine D2(high) and D3(high) receptors

scientific article published in November 2005

Antiparkinson therapeutic potencies correlate with their affinities at dopamine D2(High) receptors

scientific article published in December 2007

Antipsychotic Dosing: Extended, and Transient

scientific article published on July 1, 2012

Antipsychotic drug binding in the substantia nigra: an examination of high metoclopramide binding in the brains of normal, Alzheimer's disease, Huntington's disease, and Multiple Sclerosis patients, and its relation to tardive dyskinesia

scientific article published in February 2011

Antipsychotic pathway genes with expression altered in opposite direction by antipsychotics and amphetamine

scientific article published in August 2006

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

scientific article

Blockade of G protein-coupled receptors and the dopamine transporter by a transmembrane domain peptide: novel strategy for functional inhibition of membrane proteins in vivo

scientific article published on 11 September 2003

Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans

scientific article

Cell membrane lytic action of metoclopramide and its relation to tardive dyskinesia ⬇️

scientific article published on November 29, 2011

Cocaine self-administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer-based analysis

scientific article published in July 2010

Consistent with dopamine supersensitivity, RGS9 expression is diminished in the amphetamine-treated animal model of schizophrenia and in postmortem schizophrenia brain

scientific article published in May 2007

Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus

scientific article

Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo

scientific article published on 19 November 2007

Dopamine D2(High) receptors moderately elevated by bifeprunox and aripiprazole

scientific article published on December 2008

Dopamine D2(High) receptors moderately elevated by sertindole

scientific article

Dopamine D2(High) receptors on intact cells

scientific article published in April 2008

Dopamine D2High receptors measured ex vivo are elevated in amphetamine-sensitized animals

scientific article

Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil

scientific article (publication date: August 2009)

Dopamine agonist action of phencyclidine

scientific article

Dopamine agonist radioligand binds to both D2High and D2Low receptors, explaining why alterations in D2High are not detected in human brain scans ⬇️

scientific article published on November 3, 2011

Dopamine and serotonin receptors: amino acid sequences, and clinical role in neuroleptic parkinsonism

scientific article published on July 1996

Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine

scientific article published on 14 December 2005

Dopamine displaces [3H]domperidone from high-affinity sites of the dopamine D2 receptor, but not [3H]raclopride or [3H]spiperone in isotonic medium: Implications for human positron emission tomography

scientific article

Dopamine partial agonist action of (-)OSU6162 is consistent with dopamine hyperactivity in psychosis

scientific article

Dopamine partial agonist actions of the glutamate receptor agonists LY 354,740 and LY 379,268.

scientific article

Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis

scientific article

Elevated dopamine D2High receptors in alpha-1b-adrenoceptor knockout supersensitive mice

scientific article published on 01 July 2007

Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity

scientific article published on November 2010

First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study

scientific article published on 4 April 2007

Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor

scientific article published in October 2009

Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors

scientific article

Glutamate drug reduces dopamine inhibition of phosphorylation

scientific article published on 19 November 2015

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

scientific article published in March 2009

High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO.

scientific article published on 20 December 2005

Hyperactive mice show elevated D2(High) receptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts

scientific article published in October 2010

Increase of dopamine D2(High) receptors in the striatum of rats sensitized to caffeine motor effects

scientific article

Increased dopamine D2(High) receptors in amphetamine-sensitized rats, measured by the agonist [(3)H](+)PHNO.

scientific article published in May 2007

Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity.

scientific article published in July 2007

Increased dopamine D2High receptors in rats reared in social isolation

scientific article published in June 2009

Increased proportion of high-affinity dopamine D2 receptors in rats with excitotoxic damage of the entorhinal cortex, an animal model of schizophrenia

scientific article published on 28 July 2005

Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive-compulsive disorder (OCD).

scientific article

Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery

scientific article

Link between dopamine D1 and D2 receptors in rat and human striatal tissues

scientific article published in March 2003

Memantine agonist action at dopamine D2High receptors

scientific article

Parkinson's disease treatment may cause impulse-control disorder via dopamine D3 receptors

scientific article

Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2High receptors: D2 basis for schizophrenia

scientific article

Psychosis pathways converge via D2high dopamine receptors

scientific article

Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.

scientific article published in June 2005

Radiosynthesis, ex vivo and in vivo evaluation of [11C]preclamol as a partial dopamine D2 agonist radioligand for positron emission tomography.

scientific article published in September 2006

Rats with persistently high exploratory activity have both higher extracellular dopamine levels and higher proportion of D(2) (High) receptors in the striatum

scientific article published in May 2009

Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene

scientific article published in October 2003

Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization

scientific journal article

Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [(18)F]F-PHNO.

scientific article published on 17 January 2007

The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia

scientific article

The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors.

scientific article

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