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List of works by Tomonori Hirose

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

scientific article published on 15 September 2020

ASPP2 regulates epithelial cell polarity through the PAR complex.

scientific article published on 8 July 2010

An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3

scientific article

An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms

scientific article

Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing

scientific article published on 08 January 2019

Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome

scientific journal article

Dynamic changes in protein components of the tight junction during liver regeneration

scientific article published on 01 September 2001

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

scientific article published on 24 February 2010

Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy.

scientific article published on 4 August 2010

Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities

scientific article published on 12 December 2019

Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.

scientific article published on 25 August 2010

Involvement of Runx3 in the basal transcriptional activation of the mouse angiotensin II type 1 receptor-associated protein gene.

scientific article published on 17 May 2011

Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains

scientific article (publication date: 2013)

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice

scientific journal article

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity ⬇️

scientific article published on April 29, 2003

Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation

scientific article (publication date: 14 January 2000)

Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages

scientific article published on 10 November 2006

Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells.

scientific article

PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow

scientific article published on 17 July 2018

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

scientific article

PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.

scientific article

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR3

scientific article published on 22 October 2020

Prepubertal angiotensin blockade exerts long-term therapeutic effect through sustained ATRAP activation in salt-sensitive hypertensive rats

scientific article published on 01 October 2011

Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells

scientific article published in November 2002

Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions

scientific article published in Journal of Biological Chemistry

Spatial regulation of VEGF receptor endocytosis in angiogenesis

scientific journal article

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

scientific article

The role of Mediator and Little Elongation Complex in transcription termination

scientific article published on 26 February 2020

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis

scientific article published in September 2012

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

scientific article published in Nature Communications

aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region.

scientific article published on 28 January 2008

aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.

scientific article published on 3 April 2014

sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.

scientific article published on 9 September 2004

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