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List of works by John P. Hegarty

A general model for multilocus epistatic interactions in case-control studies

scientific article

A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease.

scientific article published in September 2013

Advances in therapeutic bacterial antisense biotechnology

scientific article published on 5 December 2017

An interleukin-4 polymorphism is associated with susceptibility to Clostridium difficile infection in patients with inflammatory bowel disease: results of a retrospective cohort study

scientific article published on October 2014

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

scientific article published on 10 January 2018

Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease

scientific article published on 10 June 2009

Association of the haem oxygenase-1 gene with inflammatory bowel disease

scientific article published on 02 August 2017

Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study

scientific article published on 25 May 2016

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile.

scientific article

Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile.

scientific article published on 19 April 2018

Characterization of Clostridium difficile isolates from human fecal samples and retail meat from Pennsylvania

scientific article published on 01 October 2014

Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study.

scientific article

DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility

scientific article published on 8 November 2011

Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene

scientific article published on 15 March 2011

Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1 ⬇️

scientific article published on June 1, 2012

Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease.

scientific article

Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell lines.

scientific article

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

scientific article published on July 2017

Genetic risk profiling and gene signature modeling to predict risk of complications after IPAA.

scientific article published in March 2012

Identification of disease-associated DNA methylation in B cells from Crohn's disease and ulcerative colitis patients.

scientific article

Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease

scientific article published in November 2012

Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease

article

NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells

scientific article

NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes

scientific article published on 26 May 2013

NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.

scientific article published on November 2010

Occurrence of Helicobacter pylori in surface water in the United States

scientific article published on 01 November 1999

Phage tail-like particles kill Clostridium difficile and represent an alternative to conventional antibiotics

scientific article

Predicting recurrence of C. difficile colitis using bacterial virulence factors: binary toxin is the key

scientific article published on 20 October 2012

Presence of Helicobacter pylori in drinking water is associated with clinical infection

scientific article published on 01 January 2001

Proton pump inhibitors induce changes in colonocyte gene expression that may affect Clostridium difficile infection.

scientific article published on 21 August 2014

Single nucleotide polymorphisms of the tcdC gene and presence of the binary toxin gene predict recurrent episodes of Clostridium difficile infection

scientific article published in August 2014

T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease

scientific article published on 17 January 2014

The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients

scientific article published on 16 August 2017

The TNFSF15 gene single nucleotide polymorphism rs7848647 is associated with surgical diverticulitis

scientific article published in June 2014

Ulcerative colitis neoplasia is not associated with common inflammatory bowel disease single-nucleotide polymorphisms.

scientific article

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