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List of works by Leen M 't Hart

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

scientific article published on October 2016

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

scientific article published on 10 May 2017

A SNP panel for identification of DNA and RNA specimens

scientific article

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

scientific article

Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels

scientific article published on 4 November 2009

BclI Glucocorticoid Receptor Polymorphism Is Associated With Greater Body Fatness: The Hoorn and CODAM Studies

BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies

scientific article published on 17 January 2017

BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies

scientific article published on 2 July 2015

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

CONQUER: an interactive toolbox to understand functional consequences of GWAS hits

scientific article published on 27 October 2020

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study

scientific article published on 17 October 2020

Cohort Profile: The Hoorn Studies

scientific article published on 13 December 2017

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk ⬇️

scientific article published on 17 June 2009

Combined gene and protein expression of hormone-sensitive lipase and adipose triglyceride lipase, mitochondrial content, and adipocyte size in subcutaneous and visceral adipose tissue of morbidly obese men.

scientific article published on 14 October 2011

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

scientific article

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp

scientific article (publication date: 2012)

Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

scientific article published on 13 June 2012

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

scientific article published on 10 August 2021

Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control

scientific article published on 13 February 2013

Evaluation of the importance of maternal history of diabetes and of mitochondrial variation in the development of NIDDM.

scientific article

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

scientific article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

scientific article published on 19 November 2012

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

scientific article

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

scientific article

Genetic association analysis of LARS2 with type 2 diabetes

scientific article (publication date: 2010)

Genetic factors and insulin secretion: gene variants in the IGF genes

scientific article published in February 2004

Genetic influences on the insulin response of the beta cell to different secretagogues

scientific article published on 3 October 2009

HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness

scientific article published on 01 December 2000

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes.

scientific article

Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging

article

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

scientific article published in 2023

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

scientific article

Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention.

scientific article

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

scientific article published on 2 January 2018

Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus

scientific article

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

scientific article

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

scientific article

Maternally inherited diabetes and deafness (MIDD): unusual occult exocrine pancreatic manifestation in an affected German family

scientific article published in January 2000

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

scientific article published on 21 September 2017

Metformin and statin use associate with plasma protein N-glycosylation in people with type 2 diabetes

scientific article published on 01 July 2020

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

scientific article

Mitochondrial diabetes: molecular mechanisms and clinical presentation

scientific article published on February 2004

Molecular mechanisms of mitochondrial diabetes (MIDD).

scientific article

Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study

scientific article published on 28 November 2007

New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome

scientific article

Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study

scientific article published on 28 September 2021

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

scientific article published on 19 June 2020

Progressive sensorineural hearing impairment in maternally inherited diabetes mellitus and deafness (MIDD).

scientific article published in September 2006

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study ⬇️

scientific article published on 10 June 2021

SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus

scientific article

Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.

scientific article published on 18 May 2010

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

scientific article

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

scientific article published on 14 May 2013

The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study

scientific article published in November 2006

The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands

scientific article published on 06 June 2017

The association between the -374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies

scientific article published in February 2010

The association of mitochondrial content with prevalent and incident type 2 diabetes.

scientific article published on 11 February 2010

The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease

scientific article published on 20 January 2020

The heritability of beta cell function parameters in a mixed meal test design

scientific article

The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia

scientific article published on 8 September 2010

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype.

scientific article published on January 1996

Tumor necrosis factor-alpha plays an important role in restenosis development

scientific article published in December 2005

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

scientific article

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

scientific article published on 11 July 2008

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

scientific article published on 08 August 2016

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

scientific article published in March 2002

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell

scientific article published in October 2002

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