List of works by Paola Spessotto

Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis

scientific article published on 31 August 2019

Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A.

scientific article published on June 2004

An EMILIN1-negative microenvironment promotes tumor cell proliferation and lymph node invasion.

scientific article published on 24 July 2012

An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development

scientific article

Antigene effect in K562 cells of a PEG-conjugated triplex-forming oligonucleotide targeted to the bcr/abl oncogene

scientific article

Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism.

scientific article

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells.

scientific article

Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease

scientific journal article

Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events.

scientific article

Distribution of PG-M/versican variants in human tissues and de novo expression of isoform V3 upon endothelial cell activation, migration, and neoangiogenesis in vitro

scientific article published on 6 September 2002

EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.

scientific article

Emilin1 deficiency causes structural and functional defects of lymphatic vasculature.

scientific article published on 14 April 2008

Evaluation of neoangiogenesis in locally advanced gastric cancer before and after neoadjuvant radiochemotherapy by probe confocal laser endomicroscopy (PCLE)

scientific article published on 01 July 2019

Expression profiles in malignant fibrous histiocytomas: Clues for differentiating ‘spindle cell’ and ‘pleomorphic’ subtypes

scientific article published in January 2008

Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender

scientific article published on 10 September 2015

Human eosinophil peroxidase enhances tumor necrosis factor and hydrogen peroxide release by human monocyte-derived macrophages

scientific article

Human neutrophils specifically interact with human monocyte-derived macrophage monolayers

scientific article published in 2000

Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9.

scientific article

Identification of Domains Responsible for von Willebrand Factor Type VI Collagen Interaction Mediating Platelet Adhesion under High Flow

scientific article published in Journal of Biological Chemistry

Identification of elastase in human eosinophils: immunolocalization, isolation, and partial characterization.

scientific article published on January 1992

Inhibition of B16 melanoma metastases with the ruthenium complex imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate and down-regulation of tumor cell invasion.

scientific article published on 20 December 2005

Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis

scientific article published on 26 October 2018

Laminin-332 (Laminin-5) is the major motility ligand for B cell chronic lymphocytic leukemia.

scientific article published on 11 April 2007

Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model

scientific article published on 26 February 2016

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

scientific article published in 2018

MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment

scientific article

MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.

scientific article published on 27 October 2011

Multiplex staining depicts the immune infiltrate in colitis-induced colon cancer model

scientific article published on 02 September 2019

Multispectral imaging technology: Visualize, analyze, phenotyping, and quantify immune cells in situ

scientific article published on 01 February 2020

Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity

scientific article published on 11 January 2017

Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1.

scientific article published on 7 February 2014

Preferential locomotion of leukemic cells towards laminin isoforms 8 and 10.

scientific article published in June 2003

Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation

scientific article published on 17 June 2019

Probe-based confocal laser endomicroscopy for in vivo evaluation of the tumor vasculature in gastric and rectal carcinomas.

scientific article

Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.

scientific article published on 25 June 2009

Role of Extracellular Matrix in Gastrointestinal Cancer-Associated Angiogenesis ⬇️

scientific article published on 23 May 2020

Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells

scientific article published on 27 August 2020

The EMILIN/Multimerin family.

scientific article published on January 2011

The Probe Based Confocal Laser Endomicroscopy (pCLE) in Locally Advanced Gastric Cancer: A Powerful Technique for Real-Time Analysis of Vasculature

scientific article published on 13 June 2019

The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis

scientific article published on 20 April 2017

The extracellular matrix protein EMILIN1 silences the RAS-ERK pathway via α4β1 integrin and decreases tumor cell growth.

scientific article

The role of molecular and imaging biomarkers in the evaluation of inflammation in oncology

scientific article published on 01 February 2020

The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the alpha4beta1 integrin

scientific journal article

The α4β1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement

scientific article published on 13 October 2017

Tumor microenvironment in diffuse large B-cell lymphoma: Matrixmetalloproteinases activation is mediated by osteopontin overexpression

scientific article published on 14 September 2015

VE-cadherin is a critical molecule for trophoblast?endothelial cell interaction in decidual spiral arteries

scientific article published in October 2004

Vascular PG-M/versican variants promote platelet adhesion at low shear rates and cooperate with collagens to induce aggregation

scientific article published in December 2002

beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain.

scientific article

p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

scientific journal article

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