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List of works by Alan V. Boddy

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours.

scientific article

A Retinol Isotope Dilution Equation Predicts Both Group and Individual Total Body Vitamin A Stores in Adults Based on Data from an Early Postdosing Blood Sample

scientific article

A Strategy to Refine the Phenotyping Approach and Its Implementation to Predict Drug Clearance: A Physiologically Based Pharmacokinetic Simulation Study

scientific article published on 24 October 2018

A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT.

scientific article published on 26 March 2009

A phase I and pharmacokinetic study of ixabepilone in combination with Carboplatin in patients with advanced solid malignancies.

scientific article

A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules

scientific article published in November 2005

A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.

scientific article

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours

scientific article published on 28 September 2016

A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin

scientific article

A phase I study of nolatrexed dihydrochloride in children with advanced cancer. A United Kingdom Children's Cancer Study Group Investigation

scientific article

A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study

scientific article

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.

scientific article published on December 2016

A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia

scientific article published on 8 February 2017

A study to determine the minimum volume of blood necessary to be discarded from a central venous catheter before a valid sample is obtained in children with cancer

scientific article published in June 2007

Adaptive dosing and platinum-DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours.

scientific article published on 13 February 2007

Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma.

scientific article

Age-Dependent Pharmacokinetics of Doxorubicin in Children with Cancer.

scientific article published on 30 April 2015

An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion, and vitamin A status in humans

scientific article

An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.

scientific article published on 24 May 2006

Application of a linear recirculation model to drug targeting

scientific article published in June 1991

Biliary excretion of etoposide in children with cancer.

scientific article published on 18 January 2006

Binding of sulfonamides to carbonic anhydrase: influence on distribution within blood and on pharmacokinetics

scientific article published on 01 March 1989

Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study

scientific article published on 25 October 2015

Carboplatin dosing in infants with retinoblastoma: a case for therapeutic drug monitoring.

scientific article published on 30 July 2012

Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

scientific article

Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer

scientific article

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

scientific article published on 11 October 2012

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP‐glucuronosyltransferases ⬇️

scientific article published on February 1, 2011

Chemotherapy in newborns and preterm babies.

scientific article published on 28 March 2012

Chemotherapy individualization.

scientific article

Cisplatin pharmacokinetics in children with cancer

scientific article published on 01 October 1997

Clinical Pharmacokinetic and Pharmacodynamic Considerations in the (Modern) Treatment of Melanoma

scientific article published on 01 August 2019

Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma

scientific article published on March 13, 1992

Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol

scientific article published on June 1, 1992

Comparison of continuous infusion and bolus administration of ifosfamide in children

scientific article published on 01 January 1995

Comparison of methods for the estimation of carboplatin pharmacokinetics in paediatric cancer patients

scientific article published in October 1995

Comparison of nonlinear mixed-effect and non-parametric expectation maximisation modelling for Bayesian estimation of carboplatin clearance in children.

scientific article

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions.

scientific article published on 4 August 2017

Cyclophosphamide metabolism in children following a 1-h and a 24-h infusion.

scientific article published in March 2001

Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma

scientific article published in January 2004

Cyclophosphamide pharmacokinetics and pharmacogenetics in children with B-cell non-Hodgkin's lymphoma

scientific article published on 11 January 2016

Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometry.

scientific article published in October 2003

Development and validation of cell-based ELISA for the quantification of trastuzumab in human plasma.

scientific article published on 17 April 2009

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

scientific article published on 4 January 2016

Dosing of cancer patients with low or absent renal function

scientific article published on 01 March 2007

Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.

scientific article published on 5 October 2015

Efficiency of drug targeting: steady-state considerations using a three-compartment model

scientific article published on 01 May 1989

Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokinetics

scientific article published on January 2004

Estimation of renal function and its potential impact on carboplatin dosing in children with cancer

scientific article published on September 2008

Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer

scientific article published on 3 August 2015

Genetic Polymorphisms Affecting Cardiac Biomarker Concentrations in Children with Cancer: an Analysis from the "European Paediatric Oncology Off-patents Medicines Consortium" (EPOC) Trial

scientific article published on 24 January 2020

Genetic variants in the HER2 gene: Influence on HER2 overexpression and loss of heterozygosity in breast cancer

scientific article published on 7 January 2016

Genetics of cisplatin ototoxicity: confirming the unexplained?

scientific article published in August 2013

High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers

scientific article published on 14 July 2015

Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics

scientific article published on 01 June 1996

Imagestream detection and characterisation of circulating tumour cells - A liquid biopsy for hepatocellular carcinoma?

scientific article published on 27 April 2016

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

scientific article published on 01 January 2019

In vitro and in vivo investigations of dihydropyridine-based chemical delivery systems for anticonvulsants

scientific article published in June 1991

Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells

scientific article published on February 2005

Influence of antibiotics on the recovery and kinetics of Saccharomyces boulardii in rats

scientific article published in June 1991

Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

scientific article

Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

scientific article

Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration

scientific article published on 01 January 1996

Investigating the heterogeneity of alkylating agents' efficacy and toxicity between sexes: A systematic review and meta-analysis of randomized trials comparing cyclophosphamide and ifosfamide (MAIAGE study).

scientific article published on 23 January 2017

Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.

scientific article published on 12 January 2018

Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate

scientific article published on 09 April 2010

Minimization of the preanalytical error in pharmacokinetic analyses and therapeutic drug monitoring: focus on IV drug administration

scientific article

Minimization of the preanalytical error in plasma samples for pharmacokinetic analyses and therapeutic drug monitoring--using doxorubicin as an example

scientific article published on 01 December 2011

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

scientific article published on 8 May 2007

Monte Carlo simulations of the clinical benefits from therapeutic drug monitoring of sunitinib in patients with gastrointestinal stromal tumours

scientific article published on 13 June 2016

NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism

scientific article published on 01 March 2007

Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia

scientific article published on 25 December 2019

Pharmacogenetic association of MBL2 and CD95 polymorphisms with grade 3 infection following adjuvant therapy for breast cancer with doxorubicin and cyclophosphamide.

scientific article published on 8 December 2016

Pharmacogenetics of adjuvant breast cancer treatment with cyclophosphamide, epirubicin and 5-fluorouracil

scientific article published on 24 July 2014

Pharmacogenetics of genes across the doxorubicin pathway.

scientific article published on October 2011

Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia

scientific article published on 19 January 2019

Pharmacokinetic and pharmacodynamic study of doxorubicin in children with cancer: results of a "European Pediatric Oncology Off-patents Medicines Consortium" trial

scientific article published on 21 October 2016

Pharmacokinetic consequences of product stereoselectivity in the metabolism of nafimidone: estimation of fraction metabolized

scientific article published on 01 August 1991

Pharmacokinetic investigation of imatinib using accelerator mass spectrometry in patients with chronic myeloid leukemia

scientific article published in July 2007

Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy

scientific article published on 04 May 2004

Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma - a study of the United Kingdom Children's Cancer Study Group.

scientific article published on 16 January 2007

Pharmacokinetics and metabolism of cyclophosphamide in paediatric patients

scientific article published on 01 January 1992

Pharmacokinetics and pharmacogenetics of 13-cis-retinoic acid in the treatment of neuroblastoma

scientific article published on 01 March 2007

Pharmacokinetics of Anticancer Drugs Used in Treatment of Older Adults With Colorectal Cancer: A Systematic Review

scientific article published on 01 October 2019

Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients

scientific article

Pharmacokinetics of cyclophosphamide and its metabolites in paediatric patients receiving high-dose myeloablative therapy

scientific article

Pharmacokinetics of dabrafenib in a patient with metastatic melanoma undergoing haemodialysis.

scientific article published on 10 November 2016

Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients

scientific article published on 01 January 1995

Pharmacological study of paclitaxel duration of infusion combined with GFR-based carboplatin in the treatment of ovarian cancer

scientific article published on 01 July 2001

Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer

scientific article published on 22 March 2016

Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.

scientific article published on 26 May 2016

Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee

scientific article published on 01 January 1998

Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma

scientific article published in August 2002

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

scientific article

Phase I study of temozolomide plus paclitaxel in patients with advanced malignant melanoma and associated in vitro investigations.

scientific article published on March 2005

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

scientific article published on December 2008

Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort

scientific article published on 01 July 2019

Plasma Retinol Kinetics and β-Carotene Bioefficacy Are Quantified by Model-Based Compartmental Analysis in Healthy Young Adults with Low Vitamin A Stores

scientific article published on 10 August 2016

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

scientific article

Population pharmacokinetics of adjuvant cyclophosphamide, methotrexate and 5-fluorouracil (CMF).

scientific article

Population pharmacokinetics of carboplatin in children

scientific article published on 01 April 1996

Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function

scientific article published on 04 November 2018

Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years

scientific article published on 13 January 2013

Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically-based pharmacokinetic modelling approach

scientific article published on 06 April 2020

Recent developments in the clinical pharmacology of classical cytotoxic chemotherapy.

scientific article published in July 2006

Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor

scientific article published on 10 October 2006

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

scientific article published on 26 April 2010

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

scientific article

Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: a pharmacokinetic study in advanced sarcoma patients. Swiss Group for Clinical Cancer Research (SAKK).

scientific article

Sources of preanalytical error in pharmacokinetic analyses - focus on intravenous drug administration and collection of blood samples.

scientific article published on 16 April 2014

Stereoselectivity in pharmacokinetics: a general theory

scientific article published on May 1, 1991

Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

scientific article

The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide

scientific article published on 01 September 1993

The implications of genetic variation for the pharmacokinetics and pharmacodynamics of aromatase inhibitors

scientific article published on 2 June 2016

The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

scientific article published on 01 January 1995

The path to implementation of personalized medicine of aromatase inhibitors in patients with breast cancer.

scientific article

The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients

scientific article published on 30 August 2018

Therapeutic monitoring of carboplatin dosing in a premature infant with retinoblastoma.

scientific article published on 8 July 2008

Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues.

scientific article

Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.

scientific article

Topotecan in combination with carboplatin: phase I trial evaluation of two treatment schedules.

scientific article

Towards a Model-Based Dose Recommendation for Doxorubicin in Children.

scientific article published on 19 September 2016

Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules

scientific article published on 20 February 2014

Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy

scientific article published on 01 December 2011

Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort

scientific article published on 16 November 2019

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