List of works - Silvia Ortega-Gutiérrez

2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.

scientific article published on 27 February 2018

2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.

scientific article

A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

scientific article published on 22 April 2015

A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration

scientific article published on 16 December 2019

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

scientific article published on 19 June 2019

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

scientific article published on 08 October 2014

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington's disease.

scientific article published on 09 May 2016

A fluorescent probe to unravel functional features of cannabinoid receptor CB1 in human blood and tonsil immune system cells

scientific article published on 9 January 2018

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

scientific article published on 16 December 2011

Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis

scientific article published on 7 June 2005

Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons

scientific article published on 23 March 2019

Blocking Ras inhibition as an antitumor strategy

scientific article

CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches

scientific article

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.

scientific article published on 12 January 2004

Chemical probes for the recognition of cannabinoid receptors in native systems

scientific article

Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake

scientific article

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

scientific article published in April 2003

Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.

scientific article

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

scientific article published on 14 May 2010

Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-HT1A Receptor in Native Cells of the Immune System

article

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

scientific article

Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors

scientific article published on 27 June 2011

Development of molecular probes for the human 5-HT(6) receptor.

scientific article published on October 2010

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy

scientific article published on 27 January 2011

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

scientific article

Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.

scientific article

Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures.

scientific article published in November 2005

Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels

scientific article published in August 2005

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

scientific article published on 15 June 2015

Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin

scientific article published in June 2003

Ligand chain length drives activation of lipid G protein-coupled receptors

scientific article published on 17 May 2017

Mitochondrial CB₁ receptors regulate neuronal energy metabolism

scientific article published on 4 March 2012

Neurochemical effects of the endocannabinoid uptake inhibitor UCM707 in various rat brain regions.

scientific article published on 23 November 2006

New inhibitors of angiogenesis with antitumor activity in vivo

scientific article published on 4 May 2015

New synthetic inhibitors of fatty acid synthase with anticancer activity

scientific article published on 16 May 2012

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

scientific article published on 01 December 2009

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

scientific article

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

scientific article

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

scientific article

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

scientific article

The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation.

scientific article published on December 2010

The expression of cannabinoid receptor 1 is significantly increased in atopic patients

scientific article published on 31 January 2014

The medicinal chemistry of agents targeting monoacylglycerol lipase.

scientific article published on January 2008

Therapeutic perspectives of inhibitors of endocannabinoid degradation.

scientific article

UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide

scientific article published in August 2002

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

scientific article published on 11 July 2005

Unique pharmacological properties of serotonergic G-protein coupled receptors from cestodes.

scientific article published on 9 February 2018

VR1 Receptor Modulators as Potential Drugs for Neuropathic Pain ⬇️

scientific article published on November 1, 2003

[Cannabinoid system and neuroinflammation:therapeutic perspectives in multiple sclerosis]

scientific article published on 01 November 2006

List of works by Silvia Ortega-Gutiérrez

2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.

2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.

A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington's disease.

A fluorescent probe to unravel functional features of cannabinoid receptor CB1 in human blood and tonsil immune system cells

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis

Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons

Blocking Ras inhibition as an antitumor strategy

CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.

Chemical probes for the recognition of cannabinoid receptors in native systems

Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-HT1A Receptor in Native Cells of the Immune System

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors

Development of molecular probes for the human 5-HT(6) receptor.

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.

Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures.

Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin

Ligand chain length drives activation of lipid G protein-coupled receptors

Mitochondrial CB₁ receptors regulate neuronal energy metabolism

Neurochemical effects of the endocannabinoid uptake inhibitor UCM707 in various rat brain regions.

New inhibitors of angiogenesis with antitumor activity in vivo

New synthetic inhibitors of fatty acid synthase with anticancer activity

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation.

The expression of cannabinoid receptor 1 is significantly increased in atopic patients

The medicinal chemistry of agents targeting monoacylglycerol lipase.

Therapeutic perspectives of inhibitors of endocannabinoid degradation.

UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

Unique pharmacological properties of serotonergic G-protein coupled receptors from cestodes.

VR1 Receptor Modulators as Potential Drugs for Neuropathic Pain ⬇️

[Cannabinoid system and neuroinflammation:therapeutic perspectives in multiple sclerosis]