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List of works by Christopher J. Welch

A competitive and reversible deactivation approach to catalysis-based quantitative assays.

scientific article published on 19 February 2016

A miniature mass spectrometer for liquid chromatography applications

scientific article published on 01 November 2011

A simple parallel gas chromatography column screening system

article

Accelerated Forced Degradation of Pharmaceuticals in Levitated Microdroplet Reactors

scientific article published on 30 April 2018

An Asymmetric, Catalytic (4 + 3) Cycloaddition Reaction of Cyclopentenyl Oxyallylic Cations.

scientific article published on 25 July 2017

Antenna Biphenols: Development of Extended Wavelength Chiroptical Reporters

article

Are We Approaching a Speed Limit for the Chromatographic Separation of Enantiomers?

scientific article published on 7 August 2017

Asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes as key components of substance p antagonists

scientific article published in August 2002

Benzophenone and its analogs bind to human glyoxalase 1.

scientific article published on 15 September 2015

Capture of reactive monophosphine-ligated palladium(0) intermediates by mass spectrometry

scientific article published on 28 October 2015

Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at α2-adrenoceptors

article

Christopher J. Welch, Mirlinda Biba, Joseph R. Gouker, Gary Kath, Paul Augustine, Paul Hosek, Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool,Chirality (2007) 19(3)184 – 189

scholarly article published 2007 in Chirality

Chromatographic resolution of closely related species in pharmaceutical chemistry: dehalogenation impurities and mixtures of halogen isomers.

scientific article published on 20 December 2013

Chromatographic resolution of closely related species: drug metabolites and analogs

scientific article published on 10 April 2014

Chromatographic resolution of closely related species: separation of warfarin and hydroxylated isomers

scientific article

Chromatographic separation and assignment of absolute configuration of hydroxywarfarin isomers.

scientific article published on 13 December 2013

Cyclic sulfamide gamma-secretase inhibitors.

scientific article published in October 2005

Design and synthesis of C2-symmetric N-heterocyclic carbene precursors and metal carbenoids

scientific article

Design, Synthesis, and Characterization of Mesogenic Amine-Capped Nematic Gold Nanoparticles with Surface-Enhanced Plasmonic Resonances

scientific article published on 07 March 2012

Design, synthesis and evaluation of stationary phases for improved achiral supercritical fluid chromatography separations.

scientific article published on 24 June 2013

Detection of dehalogenation impurities in organohalogenated pharmaceuticals by UHPLC–DAD–HRESIMS

scientific article published on 07 January 2014

Determination of enantiomeric composition of (-)-(R)-2-tert-butyltetrahydroimidazolidin-4-one by polarimetry, 1H NMR, and chiral SFC.

scientific article published in May 2005

Determination of the enantiomeric excess of an M3 antagonist drug substance by chemometric analysis of the IR spectra of different guest-host complexes

scientific article published in May 2006

Development of LC chiral methods for neutral pharmaceutical related compounds using reversed phase and normal phase liquid chromatography with different types of polysaccharide stationary phases

article

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

scientific article published on 3 October 2011

Effect of extra-column volume on practical chromatographic parameters of sub-2-μm particle-packed columns in ultra-high pressure liquid chromatography

scientific article published on 04 July 2012

Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography

scientific article published on 12 July 2014

Effect of pressure on the chromatographic separation of enantiomers under reversed-phase conditions

scientific article published on 28 May 2014

Effective use of preparative chiral HPLC in a preclinical drug synthesis

scientific article published on 01 November 2004

Enantioseparation of benzazoles and benzanilides on polysaccharide-based chiral columns.

scientific article published in May 2010

Estimating chromatographic enantioselectivity (α) from gradient enantioselective chromatography data.

scientific article

Estimating optimal time for fast chromatographic separations

article

Evaluation of C18 monolithic columns for radiochemical purity measurement

scientific article published on 13 July 2016

Evaluation of a compact mass spectrometer for routine support of pharmaceutical chemistry

scientific article published on 29 January 2014

Evaluation of core-shell particle columns for ion-pair reversed-phase liquid chromatography analysis of oligonucleotides.

scientific article published on 16 September 2012

Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography

scientific article published on 31 December 2013

Experimental Limiting Oxygen Concentrations for Nine Organic Solvents at Temperatures and Pressures Relevant to Aerobic Oxidations in the Pharmaceutical Industry

scientific article

Extended Length Heterobifunctional Coupling Agents for Protein Conjugations

scientific article published on 01 January 1996

Extending the range of supercritical fluid chromatography by use of water-rich modifiers

article

Factors influencing the interconversion of a new class of dibenzodiazepine sulfonamide atropisomers

scientific article published on 01 January 2009

Factors influencing the separation of oligonucleotides using reversed-phase/ion-exchange mixed-mode high performance liquid chromatography columns ⬇️

scientific article published on June 27, 2013

Fast methods of enantiopurity determination for the Soai reaction: towards a general enantioenrichment detector?

scientific article published in January 2007

Formation of highly enantioenriched microenvironments by stochastic sorting of conglomerate crystals: A plausible mechanism for generation of enantioenrichment on the prebiotic earth

scientific article published on 01 August 2001

High-throughput metal screening in pharmaceutical samples by ICP-MS with automated flow injection using a modified HPLC configuration

scientific article published on 15 August 2009

Hydroxypyridyl Imines: Enhancing Chromatographic Separation and Stereochemical Analysis of Chiral Amines via Circular Dichroism

article

Identification and Characterization of Isomeric Intermediates in a Catalyst Formation Reaction by Means of Speciation Analysis Using HPLC−ICPMS and HPLC−ESI-MS

scientific article published on 01 February 2006

Improved chiral SFC screening for analytical method development

scientific article published on 15 August 2013

Improved method for rapid evaluation of chiral stationary phase libraries.

scientific article

Improving sensitivity in chiral supercritical fluid chromatography for analysis of active pharmaceutical ingredients

article

Investigation of a new core–shell particle column for ion-pair reversed-phase liquid chromatography analysis of oligonucleotides

scientific article published on 26 March 2014

Investigation of the stability of Chiralpak AD chiral stationary phase under various solvent conditions and development of a method to identify stationary phase-derived polymer contamination

article

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers

scientific article

Is it possible to estimate the enantioselectivity of a chiral catalyst from its racemic mixture?

scientific article

Liquid chromatographic resolution of racemic amines, amino alcohols and related compounds on a chiral crown ether stationary phase

scientific article

Looking forward in pharmaceutical process chemistry.

scientific article

MISER chiral supercritical fluid chromatography for high throughput analysis of enantiopurity

scientific article

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS

scientific article published on 24 May 2018

Mass Activated Droplet Sorting (MADS) Enables High-Throughput Screening of Enzymatic Reactions at Nanoliter Scale

scientific article published on 28 January 2020

Mechanistic study of enantiomeric recognition with native gamma-cyclodextrin by capillary electrophoresis, reversed-phase liquid chromatography, nuclear magnetic resonance spectroscopy, electrospray mass spectrometry and circular dichroism technique

scientific article

Microscale HPLC enables a new paradigm for commercialization of complex chiral stationary phases

scientific article published on 01 July 2008

Mining Chromatographic Enantioseparation Data Using Matched Molecular Pair Analysis.

scientific article

Multiparallel chiral method development screening using an 8-channel microfluidic HPLC system

article

Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis

article

Multiple-injection high-throughput gas chromatography analysis

scientific article published on 13 June 2016

New chiral crown ether stationary phase for the liquid chromatographic resolution of alpha-amino acid enantiomers.

scientific article published in March 2001

Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.

scientific article published in June 2009

Optical Chirality Sensing with a Stereodynamic Aluminum Biphenolate Probe

scientific article published on 27 July 2018

Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

scientific article published on 20 November 2014

Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study.

scientific article

Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0.

scientific article published on 27 October 2005

Professor André Collet 1945-1999.

scientific article published in January 2000

Pushing the speed limit in enantioselective supercritical fluid chromatography

scientific article published on 17 July 2015

Rapid Catalyst Identification for the Synthesis of the Pyrimidinone Core of HIV Integrase Inhibitors

article

Reactive resin facilitated preparation of an enantiopure fluorobicycloketone

scientific article

Removal of common organic solvents from aqueous waste streams via supercritical C02 extraction: a potential green approach to sustainable waste management in the pharmaceutical industry.

scientific article published on March 2009

Search for improved fluorinated stationary phases for separation of fluorine-containing pharmaceuticals from their desfluoro analogs

scientific article published on 17 December 2014

Selective Removal of a Pharmaceutical Process Impurity Using a Reactive Resin

Serendipitous discovery of a pH-dependant atropisomer bond rotation: toward a write-protectable chiral molecular switch?

scientific article published in November 2008

Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool

article

Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist

scientific article published on 30 June 2004

Strategic use of preparative chiral chromatography for the synthesis of a preclinical pharmaceutical candidate

article

Studies on the racemization of a stereolabile 5-aryl-thiazolidinedione

scientific article published on 01 February 2003

Supercritical fluid chromatography for GMP analysis in support of pharmaceutical development and manufacturing activities

article

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry.

scientific article published on April 2014

Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent

scientific article

Systematic approach to conformational sampling for assigning absolute configuration using vibrational circular dichroism

scientific article published on 02 January 2014

Systematic evaluation of new chiral stationary phases for supercritical fluid chromatography using a standard racemate library

scientific article

The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

scientific article published on 24 March 2012

Toward structure-based predictive tools for the selection of chiral stationary phases for the chromatographic separation of enantiomers

scientific article published on 20 May 2016

Ultrafast Chiral Chromatography as the Second Dimension in Two-Dimensional Liquid Chromatography Experiments.

scientific article

Ultrafast separation of fluorinated and desfluorinated pharmaceuticals using highly efficient and selective chiral selectors bonded to superficially porous particles

scientific article published on 28 November 2015

Use of Chiral HPLC-MS for Rapid Evaluation of the Yeast-Mediated Enantioselective Bioreduction of a Diaryl Ketone

scientific article published on 01 October 2001

Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity

scientific article published on 18 April 2016

Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development.

scientific article published on 20 June 2016

Virtual conferences becoming a reality

scientific article published on 01 March 2010

William H. Pirkle: Stereochemistry pioneer

scientific article published on 10 May 2020

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