List of works - Morgane Bomsel

A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs.

scholarly article

A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients

scientific article

Alpha6beta1 integrin expressed by sperm is determinant in mouse fertilization

scientific article

Annexin expressions are temporally and spatially regulated during rat hepatocyte differentiation ⬇️

scientific article published on October 1, 2001

B7 cosignal potentiates apoptosis of uninfected CD4+ T lymphocytic cell lines primed by HIV envelope proteins.

scientific article published on April 1999

Biochemical and functional characterization of three types of coated vesicles in bovine adrenocortical cells: implication in the intracellular traffic

scientific article published on 01 September 1988

Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR.

scientific article

Both lipid environment and pH are critical for determining physiological solution structure of 3-D-conserved epitopes of the HIV-1 gp41-MPER peptide P1.

scientific article

Both the Gsα and βγ subunits of the heterotrimeric G protein, Gs, control the sorting of the polymeric immunoglobulin receptor into transcytotic vesicles

scientific article published on 01 May 1994

CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion

scientific article published on 17 January 2006

Calcitonin gene-related peptide induces HIV-1 proteasomal degradation in mucosal Langerhans cells.

scientific article published on 13 September 2017

Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission

scientific article published on 30 September 2013

Calcitonin gene-related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism.

scientific article

Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection

scientific article

Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing.

scientific article

Clustering in coated vesicles of polyunsaturated phospholipids segregated from plasma and Golgi membranes of adrenocortical cells

scientific article published on 01 July 1987

Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition.

scientific article published on 11 August 2005

Cyclic QDE peptide increases fertilization rates and provides healthy pups in mouse

scientific article

Dictyostelium discoideum cells shed vesicles with associated DNA and vital stain Hoechst 33342 ⬇️

scientific article published on May 1, 1998

Early events in HIV transmission through a human reconstructed vaginal mucosa

scientific article

Endocytosis in filter-grown Madin-Darby canine kidney cells.

scientific article

Evolution of cytoplasmic and membrane parameters during human oocyte maturation

scientific article published in July 1996

GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium.

scientific article published on 05 March 2010

Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte derived dendritic cells to autologous T cells

article

Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins

scientific article published on 17 May 2011

HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis

scientific article published on 8 July 2009

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

scientific article published on 04 February 2019

HIV-1 transmission in the male genital tract

scientific article

HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer.

scientific article published on 22 June 2005

High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160.

scientific article published in September 1997

Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity

article

Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteins

Human gamete fusion can bypass beta1 integrin requirement ⬇️

scientific article published on March 1, 1998

Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR(649-684), a mucosal subunit HIV/AIDS vaccine candidate

scientific article

Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy

scientific article published on 28 September 2018

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis.

scientific article published on 29 March 2018

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

article

In adrenocortical tissue, annexins II and VI are attached to clathrin coated vesicles in a calcium-independent manner1In memoriam: This last work as well as my scientific accomplishment are dedicated to the memory of Jeffries Wyman who was my best te

scientific article published on 01 March 1998

Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations.

scientific article published on 08 January 2014

Intracellular Neutralization of HIV Transcytosis across Tight Epithelial Barriers by Anti-HIV Envelope Protein dIgA or IgM

article

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

scientific article

Ligand-blotting visualization of the LDL receptor in plasma membranes and in two classes of coated vesicles from adrenocortical cells

scientific article published on 01 May 1985

Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection.

scientific article

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

scientific article

Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery

scientific article published on 01 February 1997

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

scientific article published on August 1990

Modifications of the human oocyte plasma membrane protein pattern during preovulatory maturation

scientific article published in May 1997

Mouse offspring after microinjection of heated spermatozoa

scientific article

Mucosal IgA in exposed, uninfected subjects: evidence for a role in protection against HIV infection

scientific article

Mucosal gatekeepers: Selecting HIV viruses for early infection

article

Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells

scientific article

OA011-01. Early events of human immunodeficiency virus type 1 (HIV-1) ex vivo penetration in the foreskin mimicking HIV-1 sexual transmission

article

P11-20. HIV-1 gp41-specific mucosal IgAs from highly exposed but IgG seronegative women block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection

article

P12-16. Biochemical and immunological characterization of the plant-derived candidate HIV-1 mucosal vaccine CTB-MPR.

scientific article published on 22 October 2009

P19-02. High protection of female macaques from repeated intravaginal challenges with SHIV-162P3 upon mucosal vaccination with Gp41 subunits-virosomes

scientific article published on 22 October 2009

Partial purification of the maturation-promoting factor MPF from unfertilized eggs of Xenopus laevis

scientific article published in December 1986

Peptide P5 (residues 628-683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection

scientific article published on 16 October 2008

Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

scientific article

Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression

scientific article published on 01 March 2020

Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor.

scientific article published on December 1993

Protecting the initial site of viral entry: an alternative HIV vaccine target ⬇️

scientific article published on September 1, 2011

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes

scientific article

Role of heterotrimeric G proteins in membrane traffic ⬇️

scientific article published on December 1, 1992

Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1.

scientific article published in May 2001

Short Communication: Decreased Plasma Calcitonin Gene-Related Peptide as a Novel Biomarker for HIV-1 Disease Progression

scientific article published on 02 January 2019

Sorting of plasma membrane proteins in epithelial cells ⬇️

scientific article published on August 1, 1991

Specific lipid protein interactions characterize 3 populations of clathrin coated vesicles involved in the LDL receptor traffic

scientific article published on 01 June 1996

Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA.

scientific article

The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals

scientific article published on 14 December 2020

The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry

scientific article published on 26 April 2017

The Human Penis Is a Genuine Immunological Effector Site

scientific article published on 14 December 2017

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages.

scientific article published on 28 November 2012

The binding of HIV-1 gp41 membrane proximal domain to its mucosal receptor, galactosyl ceramide, is structure-dependent

article

The broadly neutralizing HIV-1 IgG 2F5 elicits gp41-specific antibody-dependent cell cytotoxicity in a FcγRI-dependent manner.

scientific article published on March 2011

The immunoglobulin CH1 constant region modulates antigen binding affinity and functional activities of the broadly neutralizing 2F5 HIV specific antibody

scientific article published on 11 May 2010

Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes.

scientific article published on May 2008

Transfer of oocyte membrane fragments to fertilizing spermatozoa

scientific article

Unusual feeding behavior in wild great apes, a window to understand origins of self-medication in humans: Role of sociality and physiology on learning process ⬇️

scientific article published on August 23, 2011

Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41.

scientific article published on 2 June 2012

Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans–T cell conjugates

article

[Homology between antigenic determinants of bovine clathrin and clathrin from the brown alga Laminaria digitata]

scientific article published on 01 January 1987

List of works by Morgane Bomsel

A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs.

A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients

Alpha6beta1 integrin expressed by sperm is determinant in mouse fertilization

Annexin expressions are temporally and spatially regulated during rat hepatocyte differentiation ⬇️

B7 cosignal potentiates apoptosis of uninfected CD4+ T lymphocytic cell lines primed by HIV envelope proteins.

Biochemical and functional characterization of three types of coated vesicles in bovine adrenocortical cells: implication in the intracellular traffic

Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR.

Both lipid environment and pH are critical for determining physiological solution structure of 3-D-conserved epitopes of the HIV-1 gp41-MPER peptide P1.

Both the Gsα and βγ subunits of the heterotrimeric G protein, Gs, control the sorting of the polymeric immunoglobulin receptor into transcytotic vesicles

CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion

Calcitonin gene-related peptide induces HIV-1 proteasomal degradation in mucosal Langerhans cells.

Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission

Calcitonin gene-related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism.

Cell-to-cell contact results in a selective translocation of maternal human immunodeficiency virus type 1 quasispecies across a trophoblastic barrier by both transcytosis and infection

Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing.

Clustering in coated vesicles of polyunsaturated phospholipids segregated from plasma and Golgi membranes of adrenocortical cells

Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition.

Cyclic QDE peptide increases fertilization rates and provides healthy pups in mouse

Dictyostelium discoideum cells shed vesicles with associated DNA and vital stain Hoechst 33342 ⬇️

Early events in HIV transmission through a human reconstructed vaginal mucosa

Endocytosis in filter-grown Madin-Darby canine kidney cells.

Evolution of cytoplasmic and membrane parameters during human oocyte maturation

GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium.

Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte derived dendritic cells to autologous T cells

Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins

HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

HIV-1 transmission in the male genital tract

HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer.

High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160.

Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity

Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteins

Human gamete fusion can bypass beta1 integrin requirement ⬇️

Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR(649-684), a mucosal subunit HIV/AIDS vaccine candidate

Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis.

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

In adrenocortical tissue, annexins II and VI are attached to clathrin coated vesicles in a calcium-independent manner1In memoriam: This last work as well as my scientific accomplishment are dedicated to the memory of Jeffries Wyman who was my best te

Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations.

Intracellular Neutralization of HIV Transcytosis across Tight Epithelial Barriers by Anti-HIV Envelope Protein dIgA or IgM

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

Ligand-blotting visualization of the LDL receptor in plasma membranes and in two classes of coated vesicles from adrenocortical cells

Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection.

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

Modifications of the human oocyte plasma membrane protein pattern during preovulatory maturation

Mouse offspring after microinjection of heated spermatozoa

Mucosal IgA in exposed, uninfected subjects: evidence for a role in protection against HIV infection

Mucosal gatekeepers: Selecting HIV viruses for early infection

Natural mucosal antibodies reactive with first extracellular loop of CCR5 inhibit HIV-1 transport across human epithelial cells

OA011-01. Early events of human immunodeficiency virus type 1 (HIV-1) ex vivo penetration in the foreskin mimicking HIV-1 sexual transmission

P11-20. HIV-1 gp41-specific mucosal IgAs from highly exposed but IgG seronegative women block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection

P12-16. Biochemical and immunological characterization of the plant-derived candidate HIV-1 mucosal vaccine CTB-MPR.

P19-02. High protection of female macaques from repeated intravaginal challenges with SHIV-162P3 upon mucosal vaccination with Gp41 subunits-virosomes

Partial purification of the maturation-promoting factor MPF from unfertilized eggs of Xenopus laevis

Peptide P5 (residues 628-683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection

Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression

Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor.

Protecting the initial site of viral entry: an alternative HIV vaccine target ⬇️

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes

Role of heterotrimeric G proteins in membrane traffic ⬇️

Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1.

Short Communication: Decreased Plasma Calcitonin Gene-Related Peptide as a Novel Biomarker for HIV-1 Disease Progression

Sorting of plasma membrane proteins in epithelial cells ⬇️

Specific lipid protein interactions characterize 3 populations of clathrin coated vesicles involved in the LDL receptor traffic

Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA.

The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals

The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry

The Human Penis Is a Genuine Immunological Effector Site

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages.

The binding of HIV-1 gp41 membrane proximal domain to its mucosal receptor, galactosyl ceramide, is structure-dependent

The broadly neutralizing HIV-1 IgG 2F5 elicits gp41-specific antibody-dependent cell cytotoxicity in a FcγRI-dependent manner.

The immunoglobulin CH1 constant region modulates antigen binding affinity and functional activities of the broadly neutralizing 2F5 HIV specific antibody

Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes.

Transfer of oocyte membrane fragments to fertilizing spermatozoa

Unusual feeding behavior in wild great apes, a window to understand origins of self-medication in humans: Role of sociality and physiology on learning process ⬇️

Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41.