List of works by Edward H Egelman

A DNA Pairing-enhanced Conformation of Bacterial RecA Proteins

scientific article published in Journal of Biological Chemistry

A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature

scientific article

A change in actin conformation associated with filament instability after Pi release.

scientific article

A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments

scientific article

A conformational change in the actin subunit can change the flexibility of the actin filament

scientific article

A new internal mode in F-actin helps explain the remarkable evolutionary conservation of actin's sequence and structure

scientific article

A packing for A-form DNA in an icosahedral virus

scientific article published on 21 October 2019

A structural model of flagellar filament switching across multiple bacterial species

scientific article published on 16 October 2017

A tale of two polymers: new insights into helical filaments

scientific article

A257T linker region mutant of T7 helicase-primase protein is defective in DNA loading and rescued by T7 DNA polymerase

scientific article

ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments

scientific article

ATP-mediated conformational changes in the RecA filament

scientific article (publication date: February 2003)

Acrosomal actin: twists and turns of a versatile filament

scientific article

Actin Filament Structure: The ghost of ribbons past

scientific article published on 01 January 1994

Actin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunits

scientific article

Actin filaments as tension sensors

scientific article

Actin hydrophobic loop 262-274 and filament nucleation and elongation

scientific article

Actin in the inner ear: the remarkable structure of the stereocilium

scientific article published in Nature

Actin polymerization is stimulated by actin cross-linking protein palladin

scientific article

Actin structure and function: what we still do not understand

scientific article

Actin's prokaryotic homologs ⬇️

scientific article published on April 1, 2003

Actin-destabilizing factors disrupt filaments by means of a time reversal of polymerization

scientific article

Allostery, cooperativity, and different structural states in F-actin.

scientific article

Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs

scientific article published on 01 July 2019

Ambiguities in helical reconstruction

scientific article published on 8 December 2014

An algorithm for straightening images of curved filamentous structures.

scientific article published in January 1986

Archaeal actin from a hyperthermophile forms a single-stranded filament

scientific article

Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain

scientific article

Are ParM filaments polar or bipolar?

scientific article

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

scientific article

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

scientific article

Atomic model of a myosin filament in the relaxed state

scientific article published on August 2005

Atomic structure of the Campylobacter jejuni flagellar filament reveals how ε Proteobacteria escaped Toll-like receptor 5 surveillance

scientific article published on 08 July 2020

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

scientific article

BRCA2 BRC motifs bind RAD51-DNA filaments

scientific article

Bacterial conjugation: running rings around DNA.

scientific article

Bacterial flagellar capping proteins adopt diverse oligomeric states

scientific article

Bacterial helicases.

scientific article

Binding of N-Terminus Fragments of Cardiac Myosin-Binding C-protein to Actin

Biochemical and electron microscopic image analysis of the hexameric E1 helicase.

scientific article

Biophysical Journal Special Issue: Focus on Cryo-EM.

scientific article published on February 2016

Cell walls, cell shape, and bacterial actin homologs

scientific article

Changes in the organization of actin filaments in the stereocilia of noise-damaged lizard cochleae

scientific article

Cleavage of bacteriophage lambda cI repressor involves the RecA C-terminal domain

scientific article

Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.

scientific article

Comparison of bacteriophage T4 UvsX and human Rad51 filaments suggests that RecA-like polymers may have evolved independently.

scientific article

Complexes of RecA with LexA and RecX differentiate between active and inactive RecA nucleoprotein filaments

scientific article

Cooperative rigor binding of myosin to actin is a function of F-actin structure

article published in 1997

Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament

scientific article

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

scientific article

Cryo-EM of bacterial pili and archaeal flagellar filaments

scientific article

Cryo-EM structure of the CFA/I pilus rod

scientific article published on 09 July 2019

Cryo-Em Structure of Type 1 Pilus

Cryo-reconstructions of P22 polyheads suggest that phage assembly is nucleated by trimeric interactions among coat proteins

scientific article

Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution

scientific article published in September 2017

Cryoelectron-microscopy structure of the enteropathogenic <i>Escherichia coli</i> type III secretion system EspA filament

scientific article published on 01 January 2021

Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW

scientific article

DNA conformation induced by the bacteriophage T4 UvsX protein appears identical to the conformation induced by the Escherichia coli RecA protein.

scientific article

DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase

scientific article

De novo protein structure determination from near-atomic-resolution cryo-EM maps

scientific article

Direct interaction of actin filaments with F-BAR protein pacsin2.

scientific article

Direct visualization of dynamics and co-operative conformational changes within RecA filaments that appear to be associated with the hydrolysis of adenosine 5'-O-(3-thiotriphosphate).

scientific article published in May 1992

Distinct docking and stabilization steps of the Pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers

scientific article

Divergence of quaternary structures among bacterial flagellar filaments

scientific article

Divergence of the Flagellar Hook and Filament

Do the utrophin tandem calponin homology domains bind F-actin in a compact or extended conformation?

scientific article

Does a stretched DNA structure dictate the helical geometry of RecA-like filaments?

scientific article

Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.

scientific article

Each Actin Subunit Has Three Nebulin Binding Sites

Each actin subunit has three nebulin binding sites: implications for steric blocking

scientific article (publication date: 5 March 2002)

Editorial overview

Electron microscopic studies of the translin octameric ring.

scientific article

Electron microscopy of helical filaments: rediscovering buried treasures in negative stain

scientific article

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

scientific article

Enhancement of the RAD51 Recombinase Activity by the Tumor Suppressor PALB2

F-actin is a helix with a random variable twist

scientific article published in Nature

F-actin retains a memory of angular order

scientific article

Filaments from Ignicoccus hospitalis show diversity of packing in proteins containing N-terminal type IV pilin helices

scientific article

Flexibility of the rings: structural asymmetry in the DnaB hexameric helicase

scientific article

Functional and structural basis for a bacteriophage homolog of human RAD52.

scientific article published on 24 July 2008

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.

scientific article published on 18 January 2018

Helical crystallization on lipid nanotubes: streptavidin as a model protein.

scientific article

Helical disorder and the filament structure of F-actin are elucidated by the angle-layered aggregate

scientific article published on 01 June 1983

Helical filaments of human Dmc1 protein on single-stranded DNA: a cautionary tale

scientific article

Helical structure of the needle of the type III secretion system of Shigella flexneri

scientific article (publication date: 9 May 2003)

Helicity in electron microscopy images—a comment on Wang TF, Chen LT and Wang AH 2008 BioEssays 30:48–56

High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex

scientific article

Homologous-pairing activity of the Bacillus subtilis bacteriophage SPP1 replication protein G35P.

scientific article

Homomorphous hexameric helicases: tales from the ring cycle.

scientific article published on July 1996

Hooked on motility

scientific article published on 01 October 2019

How does ATP hydrolysis control actin's associations?

scientific article

Human Dmc1 protein binds DNA as an octameric ring.

scientific article published on September 1999

Identification of a Defined Epitope on the Surface of the Active RecA-DNA Filament Using a Monoclonal Antibody and Three-dimensional Reconstruction

Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties

scientific article

Image analysis shows that variations in actin crossover spacings are random, not compensatory

scientific article published on November 1992

Implications of the RecA structure ⬇️

scientific article published on January 21, 2009

Integrative Structural Biology of a Type II Secretion Pseudopilus

Integrative Structural Biology of the Calcium Dependent Type 2 Secretion Pseudopilus

Intrastrand cross-linked actin between Gln-41 and Cys-374. III. Inhibition of motion and force generation with myosin.

scientific article published in December 1998

Issues of resolution and polymorphism in single-particle reconstruction

scientific article

Loop 2 in Saccharomyces cerevisiae Rad51 protein regulates filament formation and ATPase activity

scientific article

MDA5 assembles into a polar helical filament on dsRNA.

scientific article

Mapping of drebrin binding site on F-actin

scientific article

Mapping the interaction of cofilin with subdomain 2 on actin

scientific article

Mathematical Ability: Is Sex a Factor?

scientific article published in Science by Egelman et al.

Message from the Editor in Chief

scientific article published on 4 May 2007

Model for a novel membrane envelope in a filamentous hyperthermophilic virus

scientific article published on 22 June 2017

Modulation of yeast F-actin structure by a mutation in the nucleotide-binding cleft ⬇️

scientific article published on August 15, 1997

Molecular evolution: actin's long lost relative found.

scientific article

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.

scientific article

Molecular mechanisms of general genetic recombination: the DNA-binding sites of RecA protein

scientific article published on 01 January 1984

More Insights into Structural Plasticity of Actin Binding Proteins

article by Edward H Egelman published June 2004 in Structure

Motile systems: Tubulin-based motility races ahead.

scientific article

Near-atomic resolution for one state of F-actin

scientific article

New insights into actin filament dynamics

scientific article

Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

scientific article

Only one F-actin model

scientific article published on 01 September 1997

Opening of tandem calponin homology domains regulates their affinity for F-actin

scientific article

Organization of F-actin by Fesselin (avian smooth muscle synaptopodin 2).

scientific article

Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling

scientific article published on 22 May 2020

Outcome of the first electron microscopy validation task force meeting

scientific article (publication date: 8 February 2012)

ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA.

scientific article

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.

scientific article

Probing the structure of F-actin: cross-links constrain atomic models and modify actin dynamics.

scientific article

Problem of light piping in immunofluorescence studies

scientific article published in Nature

Problems in fitting high resolution structures into electron microscopic reconstructions

scientific article

Pumping DNA

scientific article published in Nature

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

scientific article

Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics

scientific article

Real-space processing of helical filaments in SPARX.

scientific article

RecA Assembly, One Molecule at a Time

article published in 2006

RecA-DNA helical complexes in genetic recombination.

scientific article published in April 1986

RecA-like recombination proteins in eukaryotes: functions and structures of RAD51 genes

article

Reconstruction of Helical Filaments and Tubes ⬇️

scientific article published on January 1, 2010

Reducing irreducible complexity: divergence of quaternary structure and function in macromolecular assemblies

scientific article

Refining the Structure of the Halobacterium salinarum Flagellar Filament Using the Iterative Helical Real Space Reconstruction Method: Insights into Polymorphism

Remodeling of actin filaments by ADF/cofilin proteins

scientific article

Removal of the RecA C-terminus results in a conformational change in the RecA-DNA filament

scientific article published on 01 June 1991

Reproducibility of research in biophysics

scientific article published on April 2015

Resolution advances in cryo-EM enable application to drug discovery

scientific article

RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps

scientific article published on 19 June 2017

SV40 large T antigen hexamer structure: domain organization and DNA-induced conformational changes

scientific article

Salmonella SipA polymerizes actin by stapling filaments with nonglobular protein arms

scientific article

Sickle Cell Anemia Research and a Recombinant DNA Technique

scientific article

Similarity of the yeast RAD51 filament to the bacterial RecA filament

scientific article

Single-particle reconstruction from EM images of helical filaments

scientific article

Spatial visualization of DNA in solution

scientific article published on 01 August 1991

Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome

scientific article published in 2022

Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2

scientific article

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

scientific article

Stepwise molecular display utilizing icosahedral and helical complexes of phage coat and decoration proteins in the development of robust nanoscale display vehicles

scientific article

Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly

scientific article

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

scientific article published on 7 November 2017

Structural basis for the destabilization of F-actin by phosphate release following ATP hydrolysis

scientific article published on October 20, 1992

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

scientific article

Structural basis of membrane invagination by F-BAR domains

scientific article

Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile

scientific article published in Nature Communications

Structural data suggest that the active and inactive forms of the RecA filament are not simply interconvertible

scientific article published on September 5, 1992

Structural dynamics of F-actin: I. Changes in the C terminus.

scientific article published in February 1995

Structural dynamics of F-actin: II. Cooperativity in structural transitions.

scientific article published on February 1995

Structural plasticity of helical nanotubes based on coiled-coil assemblies

scientific article

Structural polymorphism in F-actin

scientific article

Structural polymorphism in bacterial EspA filaments revealed by cryo-EM and an improved approach to helical reconstruction

scientific article

Structural polymorphism of Methanothermobacter thermautotrophicus MCM.

scientific article

Structural polymorphism of the ParM filament and dynamic instability

scientific article

Structural polymorphism of the RecA protein from the thermophilic bacterium Thermus aquaticus.

scientific article

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.

scientific article

Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

scientific article published on September 2008

Structure and function of Hib pili from Haemophilus influenzae type b.

scientific article

Structure and function of RecA-DNA complexes.

scientific article

Structure and function of large cellular assemblies

Structure and function of the adhesive type IV pilus of Sulfolobus acidocaldarius

scientific article

Structure and subunit composition of theRuvAB-holliday junction complex 1 1Edited by P. E. Wright

article

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling

scientific article

Structure of a filamentous virus uncovers familial ties within the archaeal virosphere

scientific article published on 01 January 2020

Structure of helical RecA-DNA complexes

scientific article published on 01 March 1988

Structure of helical RecA-DNA complexes. Complexes formed in the presence of ATP-gamma-S or ATP.

scientific article

Structure of helical RecA-DNA complexes. III. The structural polarity of RecA filaments and functional polarity in the RecA-mediated strand exchange reaction.

scientific article

Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex

scientific article

Structure of the Neisseria meningitidis Type IV pilus

scientific article

Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus

scientific article

Structure of the calcium-dependent type 2 secretion pseudopilus

scientific article published on 9 October 2017

Structure of the type VI secretion system contractile sheath

scientific article

Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments

scientific article published on 05 August 2020

The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn

scientific article published on 22 July 2019

The Arg non-receptor tyrosine kinase modifies F-actin structure

scientific article

The CH-domain of calponin does not determine the modes of calponin binding to F-actin

scientific article

The Current Revolution in Cryo-EM.

scientific article

The Escherichia coli RuvB branch migration protein forms double hexameric rings around DNA.

scientific article published on August 1994

The HexamericE. coliDnaB Helicase can Exist in Different Quarternary States

scientific article published on 01 May 1996

The LexA repressor binds within the deep helical groove of the activated RecA filament.

scientific article published in May 1993

The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings

scientific article

The N-terminal domains of myosin binding protein C can bind polymorphically to F-actin

scientific article

The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity

scientific article (publication date: June 2006)

The RecA hexamer is a structural homologue of ring helicases

scientific article

The RecB nuclease domain binds to RecA-DNA filaments: implications for filament loading

scientific article

The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin

scientific article

The bacteriophage phi 29 head-tail connector shows 13-fold symmetry in both hexagonally packed arrays and as single particles

scientific article

The bipolar filaments formed by herpes simplex virus type 1 SSB/recombination protein (ICP8) suggest a mechanism for DNA annealing

scientific article

The hexameric ring structure of the Escherichia coli RuvB branch migration protein

scientific article

The iterative helical real space reconstruction method: surmounting the problems posed by real polymers

scientific article

The location of DNA in RecA-DNA helical filaments.

scientific article

The location of ubiquitin in Lethocerus arthrin

scientific article

The molecular basis for flexibility in the flexible filamentous plant viruses

scientific article

The stalk region of dynamin drives the constriction of dynamin tubes

scientific article

The structure of F-pili

scientific article

The structure of a filamentous bacteriophage

scientific article

The structure of an archaeal pilus

scientific article

The structure of bacterial ParM filaments

scientific article

The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage

scientific article published on 24 April 2020

The structure of the CS1 pilus of enterotoxigenic Escherichia coli reveals structural polymorphism

scientific article

The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system

scientific article

The structures of two archaeal type IV pili illuminate evolutionary relationships

scientific article published on 09 July 2020

The utrophin actin-binding domain binds F-actin in two different modes: implications for the spectrin superfamily of proteins

scientific article

Three-dimensional reconstruction of a co-complex of F-actin with antibody Fab fragments to actin's NH2 terminus.

scientific article

Three-dimensional reconstruction of helical polymers

scientific article

Three-dimensional reconstruction of transcription termination factor rho: orientation of the N-terminal domain and visualization of an RNA-binding site.

scientific article published in June 2000

Two conformations of G-actin related to two conformations of F-actin.

scientific article

Two modes of binding of DinI to RecA filament provide a new insight into the regulation of SOS response by DinI protein

scientific article

Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions

scientific article published on September 2006

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

scientific article

Virology. A virus that infects a hyperthermophile encapsidates A-form DNA

scientific article

What is the structure of the RecA-DNA filament?

scientific article

Xin-repeats and nebulin-like repeats bind to F-actin in a similar manner

scientific article

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