List of works - Kazuhiko Shien

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

scientific article published on 24 June 2019

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.

scientific article published on 29 March 2013

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib

scientific article

Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells

scientific article published on 21 November 2018

Advantage of Induction Chemoradiotherapy for Lung Cancer in Securing Cancer-Free Bronchial Margin

scientific article published on 11 June 2017

Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer

scientific article published on 03 February 2014

Anti-tumor effect of neratinib against lung cancer cells harboring oncogene alterations

scientific article published on 08 January 2019

Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.

scientific article published on 21 February 2018

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

scientific article published on 26 February 2019

Clinical outcome of patients with recurrent non-small cell lung cancer after trimodality therapy

scientific article published on 08 February 2019

Clinicopathological characteristics and lymph node metastasis pathway of non-small-cell lung cancer located in the left lingular division.

scientific article published on 24 March 2015

Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis

scientific article published on 06 October 2018

Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

scientific article published on 01 January 2021

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness

scientific article published on 14 May 2019

DNA copy number gains in malignant pleural mesothelioma

scientific article

Density of tumor-infiltrating FOXP3+ T cells as a response marker for induction chemoradiotherapy and a potential prognostic factor in patients treated with trimodality therapy for locally advanced non-small cell lung cancer

scientific article

Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies

scientific article published on January 2017

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma

scientific article published on 01 April 2019

Drug resistance to EGFR tyrosine kinase inhibitors for non-small cell lung cancer

scientific article

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.

scientific article published on 26 July 2017

Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

scientific article published on 23 November 2015

Extended sleeve lobectomy after induction chemoradiotherapy for non-small cell lung cancer

scientific article published on 12 September 2014

Genetic alterations in lung adenocarcinoma with a micropapillary component

scientific article published on 2 December 2015

Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.

scientific article

Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

scientific article published on 17 October 2012

Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers.

scientific article published on 03 September 2012

Induction chemoradiotherapy using docetaxel and cisplatin with definitive-dose radiation followed by surgery for locally advanced non-small cell lung cancer.

scientific article published in September 2017

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.

scientific article published on 23 December 2016

Is tumor location an independent prognostic factor in locally advanced non-small cell lung cancer treated with trimodality therapy?

scientific article published on May 2017

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

scientific article

Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion

scientific article published on 21 March 2019

Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression

scientific article published on 27 February 2019

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

scientific article published on 14 December 2018

Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

scientific article published on 07 December 2013

Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma.

scientific article published on January 2014

Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer

scientific article

Presence of the minor EGFR T790M mutation is associated with drug-sensitive EGFR mutations in lung adenocarcinoma patients.

scientific article published on 16 May 2014

Primary lung cancer surgery after curative chemoradiotherapy for esophageal cancer patients.

scientific article published on 25 March 2011

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

scientific article published on 03 March 2012

Pulmonary mucosa-associated lymphoid tissue lymphoma with a pulmonary arteriovenous fistula.

scientific article published on 6 May 2011

Pulmonary resection in a prone position for lung cancer invading the spine

scientific article published on 21 March 2019

Role of surgery in N2 NSCLC: pros.

scientific article published on 21 September 2016

Sacrificing the pulmonary arterial branch to the spared lobe is a risk factor of bronchopleural fistula in sleeve lobectomy after chemoradiotherapy

scientific article published on 01 June 2012

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer

scientific article published on 11 October 2011

Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.

scientific article published on 13 January 2017

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma

scientific article published on 10 October 2013

The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.

scientific article published on 5 April 2016

Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.

scientific article

Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations.

scientific article published on 15 April 2018

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.

scientific article published on 13 March 2018

Use of a vessel sealing system versus conventional electrocautery for lung parenchymal resection: a comparison of the clinicopathological outcomes in porcine lungs

scientific article published on 15 March 2013

Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients

scientific article published on 31 October 2013

YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers

scientific article published on 16 January 2020

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

scientific article

exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis

scientific article published on 04 December 2018

ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

scientific article published on 18 September 2017

List of works by Kazuhiko Shien

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib

Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells

Advantage of Induction Chemoradiotherapy for Lung Cancer in Securing Cancer-Free Bronchial Margin

Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer

Anti-tumor effect of neratinib against lung cancer cells harboring oncogene alterations

Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Clinical outcome of patients with recurrent non-small cell lung cancer after trimodality therapy

Clinicopathological characteristics and lymph node metastasis pathway of non-small-cell lung cancer located in the left lingular division.

Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis

Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness

DNA copy number gains in malignant pleural mesothelioma

Density of tumor-infiltrating FOXP3+ T cells as a response marker for induction chemoradiotherapy and a potential prognostic factor in patients treated with trimodality therapy for locally advanced non-small cell lung cancer

Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma

Drug resistance to EGFR tyrosine kinase inhibitors for non-small cell lung cancer

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.

Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Extended sleeve lobectomy after induction chemoradiotherapy for non-small cell lung cancer

Genetic alterations in lung adenocarcinoma with a micropapillary component

Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.

Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers.

Induction chemoradiotherapy using docetaxel and cisplatin with definitive-dose radiation followed by surgery for locally advanced non-small cell lung cancer.

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.

Is tumor location an independent prognostic factor in locally advanced non-small cell lung cancer treated with trimodality therapy?

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion

Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma.

Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer

Presence of the minor EGFR T790M mutation is associated with drug-sensitive EGFR mutations in lung adenocarcinoma patients.

Primary lung cancer surgery after curative chemoradiotherapy for esophageal cancer patients.

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

Pulmonary mucosa-associated lymphoid tissue lymphoma with a pulmonary arteriovenous fistula.

Pulmonary resection in a prone position for lung cancer invading the spine

Role of surgery in N2 NSCLC: pros.

Sacrificing the pulmonary arterial branch to the spared lobe is a risk factor of bronchopleural fistula in sleeve lobectomy after chemoradiotherapy

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer

Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma

The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.

Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.

Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations.

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.

Use of a vessel sealing system versus conventional electrocautery for lung parenchymal resection: a comparison of the clinicopathological outcomes in porcine lungs

Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients

YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis

ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.