List of works by Vadim N. Gladyshev

1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2.

scientific article published on 4 October 2008

A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines.

scientific article

A Disease or Not a Disease? Aging As a Pathology

scientific article

A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.

scientific article published on 18 September 2015

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging

scientific article

A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins.

scientific article published on 16 May 2007

A functional link between housekeeping selenoproteins and phase II enzymes

scientific article published on July 2008

A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells

scholarly article

A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts

scientific article published on 20 June 2018

A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.

scientific article published on 27 April 2007

A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.

scientific article

A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila

scientific article published on 04 September 2008

A review of the biomedical innovations for healthy longevity

scientific article

A standard knockout procedure alters expression of adjacent loci at the translational level

scientific article published on 01 November 2021

A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues

scientific article

A whole lifespan mouse multi-tissue DNA methylation clock

scientific article published on 14 November 2018

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.

scientific article published on 3 January 2018

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus

scientific article

Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.

scientific article

Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

scientific article

Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage

article by Lucía Otero et al published 1 October 2014 in RNA

Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage.

scientific article

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

scientific article published on 29 April 2014

Age-associated molecular changes are deleterious and may modulate life span through diet

scientific article published on 17 February 2017

Aging and drug discovery

scientific article published on 01 November 2018

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

scientific article

Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology

scientific article

Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases

scientific article

Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1.

scientific article published in September 2004

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.

scientific article

An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo

scientific article published on 05 June 2020

An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes

scientific article published on 29 March 2005

Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance

scientific article

Analysis and functional prediction of reactive cysteine residues

scientific article published on 6 December 2011

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

scientific article published on 12 August 2016

Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.

scientific article

Biohorology and biomarkers of aging: current state-of-the-art, challenges and opportunities

scientific article published on 06 April 2020

Bioinformatics of selenoproteins

scientific article published on 07 February 2020

Biosynthesis of selenocysteine on its tRNA in eukaryotes

scientific article

Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis

scientific article

Boron stress activates the general amino acid control mechanism and inhibits protein synthesis

scientific article

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice

scientific article

COVID-19 is an emergent disease of aging

scientific article published on 16 April 2020

COVID-19 is an emergent disease of aging

scientific article published on 01 October 2020

CTELS: A Cell-Free System for the Analysis of Translation Termination Rate

scientific article published on 16 June 2020

CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes

scientific article

Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases

scientific article published on November 2006

Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells

scientific article published on 27 February 2015

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

scientific article

Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase

scientific journal article

Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein

scientific journal article

Characterization of mammalian selenoproteomes.

scientific article

Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins

scientific article

Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase

scientific journal article

Characterization of protein targets of mammalian thioredoxin reductases

scientific article

Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae

scientific article published on September 2010

Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec

scientific article

Comparative Genomics and Evolution of Molybdenum Utilization

scientific article

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

scientific article published on 28 January 2015

Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals

scientific article published on 21 November 2007

Comparative genetics of longevity and cancer: insights from long-lived rodents

scientific article

Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen

scientific article

Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization

scientific article

Comparative genomics analysis of the metallomes

scientific article published in January 2013

Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes

scientific article published on 23 November 2011

Comparative genomics of trace element dependence in biology

scientific article

Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function

scientific article published on October 2009

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.

scientific article published on 19 April 2018

Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives

scientific article

Comparison of selenium-containing molybdoenzymes.

scientific article

Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.

scientific article published on 17 January 2017

Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast

scientific article

Composition and evolution of the vertebrate and mammalian selenoproteomes

scientific article published in 2012

Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies

scientific article

Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis

scientific article published on 6 February 2013

Convergent evolution of marine mammals is associated with distinct substitutions in common genes

scientific article

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism

scientific article

CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function

scientific article

Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces

scientific article

Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes

scientific article

DNA METHYLATION CLOCKS IN MOUSE

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

DNA methylation aging clocks: challenges and recommendations

scientific article published on 25 November 2019

DNA repair in species with extreme lifespan differences

scientific article

Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells

scientific article

Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway

scientific article published on 18 December 2014

Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates

scientific article published on 28 September 2015

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

scientific article

Dietary selenium affects host selenoproteome expression by influencing the gut microbiota

scientific article

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

scientific article

Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases

scientific article

Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family

scientific article

Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide

scientific article

Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing

scientific journal article

Dual functions of codons in the genetic code

scientific article

Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues

scientific article published on 20 October 2006

Endogenous hydrogen sulfide production is essential for dietary restriction benefits

scientific article

Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.

scientific article published on 25 September 2009

Eukaryotic selenoproteins and selenoproteomes

scientific article

Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery

scientific journal article

Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae

scientific article

Evolution of selenium utilization traits

scientific article

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization

scientific article

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life

scientific article

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner

scientific article published on 17 January 2018

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity

scientific article published on 01 May 2020

Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae

scientific article

Functional characterization of alternatively spliced human SECISBP2 transcript variants

scientific article

Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases

scientific article published on 23 July 2008

Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74

scientific article

Functions and evolution of selenoprotein methionine sulfoxide reductases

scientific article

Gene expression defines natural changes in mammalian lifespan

scientific article

Gene expression signatures of human cell and tissue longevity.

scientific article published on 07 July 2016

General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se.

scientific article

Genetic and functional analysis of mammalian Sep15 selenoprotein.

scientific article

Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

scientific article published in 2021

Genetic code supports targeted insertion of two amino acids by one codon

scientific article

Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii

scientific article

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

scientific article

Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism

scientific article published on January 2014

Genome-wide association study of selenium concentrations

scientific article

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress

scientific article

Genomics perspective on disulfide bond formation

scientific article

Germline burden of rare damaging variants negatively affects human healthspan and lifespan

scientific article published on 07 April 2020

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.

scientific article published on 25 March 2018

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

scientific article published on 26 May 2016

HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia

scientific article

High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis

scientific article

High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin

scientific article published on 15 April 2013

High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.

scientific article published on 22 November 2011

High-throughput identification of catalytic redox-active cysteine residues

scientific article published in January 2007

High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E

scientific article published on 08 May 2020

How selenium has altered our understanding of the genetic code

scientific article

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

scientific article published on 23 May 2020

Hydrogen peroxide probes directed to different cellular compartments

scientific article

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

scientific article

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

scientific article published on 25 July 2019

Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family

scientific article published on March 2006

Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif

scholarly article

Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis

scientific journal article

Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase

scientific journal article

Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast.

scientific article

Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites

scientific article

Identification of trace element-containing proteins in genomic databases.

scientific article published on January 2004

Identity and functions of CxxC-derived motifs

scientific article published in September 2003

In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait

scientific article

In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan

scientific article published in 2022

Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression

scientific article

Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA.

scientific article

Insights into Function, Catalytic Mechanism, and Fold Evolution of Selenoprotein Methionine Sulfoxide Reductase B1 through Structural Analysis

scientific article

Insights into the Chemical Biology of Selenium

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

scientific article published on 22 October 2018

Intrinsic Versus Extrinsic Cancer Risk Factors and Aging

scientific article published on 17 August 2016

Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size

scientific article

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

scientific article published on 18 November 2019

Is there a twenty third amino acid in the genetic code?

scientific article

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

scientific article

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice

scientific article

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

scientific article published on 07 March 2019

Latest advances in aging research and drug discovery

scientific article published on 21 November 2019

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

scientific article

Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.

scientific article

Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems

scientific article

Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism

scientific article

Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration

scientific article published on 16 March 2020

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

scientific article published on 01 February 2019

Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods

scientific article published in January 2002

Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element

scientific article

Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation

scientific article published on 18 May 2005

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets

scientific journal article

Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase.

scientific article published on 12 August 2008

Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins

scientific article

Mechanisms of cancer resistance in long-lived mammals.

scientific article published on 5 April 2018

Methionine restriction and life-span control

scientific article

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

scientific article

Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice

scientific article

Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging

scientific article

Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.

scientific article

Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals

scientific article published on November 2007

Methionine sulfoxide reduction and the aging process

scientific article published on 01 April 2007

Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases

scientific article

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

scientific article published on 10 July 2018

Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells.

scientific article

Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.

scientific article

Molecular signatures of aneuploidy-driven adaptive evolution

scientific article published on 30 January 2020

Molecular signatures of longevity: Insights from cross-species comparative studies.

scientific article published on 08 August 2017

Molybdoproteomes and evolution of molybdenum utilization

scientific article published on 3 April 2008

Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors

scientific article published on 23 March 2015

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

scientific article published in January 2018

Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development

scientific article

MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form

scientific article

MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation

scientific journal article

Multifaceted deregulation of gene expression and protein synthesis with age

scientific article published on 23 June 2020

N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance

scientific article published on 22 April 2020

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension

scientific article published on 01 June 2018

NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus.

scientific article published on 31 July 2007

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family

scientific article

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera

scientific article published on 13 October 2017

Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen

scientific article published in 2021

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

scientific article published on 5 February 2018

Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?

scientific article

New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea

scientific article published in December 2007

Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics

scientific article

Non-animal origin of animal thioredoxin reductases: implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions

scientific article published on February 2003

Non-enzymatic molecular damage as a prototypic driver of aging

scientific article published on 6 March 2017

Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum

scientific article

Novel metabolism in Chlamydomonas through the lens of genomics

scientific article

On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan

scientific article

Organ-specific translation elongation rates measured by in vivo ribosome profiling

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity

scientific article published on 4 November 2015

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity

scientific article

Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging

scientific article

Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality

scientific article published on 01 December 2019

Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.

scientific article published on 11 April 2008

Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys

scientific article

Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.

scientific article published on 10 April 2018

Position-dependent termination and widespread obligatory frameshifting in Euplotes translation.

scientific article

Postgenomic chemistry (IUPAC Technical Report)

Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.

scientific article published on 23 June 2016

Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs

scientific article published on 20 August 2019

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages

scientific article

Protein synthesis and quality control in aging

Proteomics: mapping reactive cysteines

scientific article published on 01 February 2011

Pyrrolysine and selenocysteine use dissimilar decoding strategies

scientific article

ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase

scientific article published in November 2005

Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase

scientific article

Recode-2: new design, new search tools, and many more genes

scientific article

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution

scientific article

Redox biology: computational approaches to the investigation of functional cysteine residues

scientific article

Redox regulation of cell signaling by thioredoxin reductases

scientific article published on January 2002

Reduced reliance on the trace element selenium during evolution of mammals

scientific article published on 31 March 2008

Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression

scientific article

Regulated methionine oxidation by monooxygenases

scientific article published on 13 February 2017

Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin reductase status

scientific article published on August 2013

Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine

scientific article published on 9 October 2015

Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1

scientific article

Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice.

scientific article

Reprogramming to recover youthful epigenetic information and restore vision

scientific article published on 02 December 2020

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

scientific article published on 31 July 2019

Reversibility of irreversible aging

scientific article published on 01 December 2018

Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS.

scientific article published on December 2002

Ribonuclease selection for ribosome profiling

scientific article published on 15 September 2016

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

scientific article published in May 2018

Role of reactive oxygen species-mediated signaling in aging.

scientific article published on 20 September 2012

Role of selenium-containing proteins in T-cell and macrophage function

scientific article

Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution

scientific article

Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice

scientific article

SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes

scientific article

SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins

scientific article published on 19 June 2013

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

scientific article published on 01 April 2019

SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family

scientific journal article

Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy

scientific article published on 22 August 2011

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium

scientific article

Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.

scientific article published on 17 December 2004

Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.

scientific article published on 11 September 2007

Selenium Deficiency Is Associated with Pro-longevity Mechanisms

scientific article published on 01 May 2019

Selenium and Methionine Sulfoxide Reduction.

scientific article published in October 2014

Selenium and selenocysteine: roles in cancer, health, and development

scientific article published on 28 January 2014

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα

scientific article

Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein

scientific article published on 16 August 2006

Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine

scientific article published on 23 April 2015

SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements

scientific article

SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans

scientific article

Selenocysteine in thiol/disulfide-like exchange reactions

scientific article published on 16 December 2012

Selenocysteine incorporation machinery and the role of selenoproteins in development and health

scientific article published on January 2006

Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli

scientific article

Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila

scientific article published in April 2005

Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing

scientific article published in January 2018

Selenocysteine-containing proteins in mammals

Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation

scientific article published on 30 April 2018

Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis

scientific article published on 09 February 2022

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

scientific article published on 16 May 2016

Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis

scientific journal article

Selenoprotein Gene Nomenclature

scientific article published on 19 September 2016

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern

scientific article published in March 2007

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

scientific article published on September 2016

Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis

scientific article published on 20 October 2011

Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage

scientific article

Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.

scientific article

Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase

scientific article

Selenoprotein S is involved in maintenance and transport of multiprotein complexes

scientific article published on September 2014

Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells

scientific article

Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice.

scientific article published in December 2005

Selenoprotein expression is essential in endothelial cell development and cardiac muscle function

scientific article published on 4 December 2006

Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis

scientific article

Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii

scientific article

Selenoproteins are essential for proper keratinocyte function and skin development

scientific article

Selenoproteins in colon cancer

Selenoproteins mediate T cell immunity through an antioxidant mechanism

scientific article published on 16 May 2008

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression

scientific article

Selenoproteins that function in cancer prevention and promotion

scientific article published on 09 March 2009

Selenoproteins: molecular pathways and physiological roles.

scientific article

Semisynthesis and characterization of mammalian thioredoxin reductase

scientific article published on April 2006

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

scientific article published on 07 May 2016

Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses

scientific article published on September 2009

Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression

scientific article published on 27 August 2009

Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks

scientific article published on 9 July 2015

Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins

scientific article

Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish.

scientific article published in August 2003

Specialized Methods

book chapter published in 2007

Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function

scientific article

Structural Analysis of Glutaredoxin Domain of Mus musculus Thioredoxin Glutathione Reductase

scientific article

Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation

scientific article

Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2

scientific article

Structure and catalytic mechanism of eukaryotic selenocysteine synthase

scientific article

Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins.

scientific article

Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks

scientific article published on 23 April 2020

Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase

scientific article

Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery

scientific article

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication

scientific article

The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways

scientific article

The Chlamydomonas genome reveals the evolution of key animal and plant functions

scientific article

The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development.

scientific article published on December 2003

The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).

scientific article published on 2 May 2017

The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology

scientific article

The Plasmodium selenoproteome

scientific article

The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum

scientific article

The biological significance of methionine sulfoxide stereochemistry

scientific article

The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens

scientific article (publication date: July 2013)

The first international mini-symposium on methionine restriction and lifespan.

scientific article

The free radical theory of aging is dead. Long live the damage theory!

scientific article published on 4 December 2013

The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast

scientific article published on 28 April 2014

The microbial selenoproteome of the Sargasso Sea

scientific article

The naked mole rat genome: understanding aging through genome analysis

scientific article published in December 2011

The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan

scientific article published on 13 June 2013

The prokaryotic selenoproteome

scientific article

The roles of thiol oxidoreductases in yeast replicative aging

scientific article published on 8 October 2010

The second international conference "genetics of aging and longevity".

scientific article published on May 2012

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice

scientific article published on February 2009

The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A

scientific article published on March 2009

The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal

scientific article

Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.

scientific article

Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.

scientific article

Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies.

scientific article

Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths

scientific article

Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds

scientific article published in February 2002

Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites

scientific article

Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

scientific article

Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells

scientific article published on 25 March 2006

Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis

scientific article

Tolerance to Selenoprotein Loss Differs between Human and Mouse

scientific article published on 01 February 2020

Translation fidelity coevolves with longevity

scientific article published on 13 July 2017

Translation inhibitors cause abnormalities in ribosome profiling experiments

scientific article

Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project

scientific article (publication date: 13 June 2008)

UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins

scientific article published on 28 May 2013

Understanding selenoprotein function and regulation through the use of rodent models

scientific article

Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.

scientific article published on April 2017

Utilization of selenocysteine in early-branching fungal phyla

scientific article published on 11 February 2019

X-ray Absorption Spectroscopy of the Molybdenum Site ofEscherichia coliFormate Dehydrogenase

article

X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis

scientific article published on 18 April 2009

dbTEU: a protein database of trace element utilization

scientific article

svist4get: a simple visualization tool for genomic tracks from sequencing experiments

scientific article published on 06 March 2019

¹H, ¹³C, and ¹⁵N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR.

scientific article published on 8 September 2011

Paulina is supported by:

About Paulina

Help