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List of works by Antonio Di Cristofano

A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice

scientific article published in March 2008

Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice

scientific article

Characterization and genomic mapping of chimeric ERV9 endogenous retroviruses-host gene transcripts ⬇️

scientific article published on January 5, 1998

Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retrovrial family ⬇️

scientific article published on August 11, 1995

Class reunion: PTEN joins the nuclear crew.

scientific article

Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.

scientific article

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

scientific article

Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner.

scientific article

Endometrial Carcinoma

scientific article published on 01 January 2007

Establishment and Characterization of Cell Lines from a Novel Mouse Model of Poorly Differentiated Thyroid Carcinoma: Powerful Tools for Basic and Preclinical Research ⬇️

scientific article published on July 18, 2011

GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.

scientific article

Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer

scientific article

Identification of regulatory elements within the minimal promoter region of the human endogenous ERV9 proviruses: accurate transcription initiation is controlled by an Inr-like element ⬇️

scientific article published on August 25, 1992

Impaired Fas response and autoimmunity in Pten+/- mice

scientific article published on 01 September 1999

In vivo adenovirus-mediated gene transduction into mouse endometrial glands: a novel tool to model endometrial cancer in the mouse

article

Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.

scientific article

MCM5 as a target of BET inhibitors in thyroid cancer cells

scientific article published on 24 February 2016

Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium

scientific article

Mobilization of an ERV9 human endogenous retroviral element during primate evolution.

scientific article published on October 1995

Modeling anaplastic thyroid carcinoma in the mouse.

scientific article

Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins

scientific article

Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer.

scientific article published on 10 June 2013

Mouse Models of Follicular and Papillary Thyroid Cancer Progression ⬇️

scientific article published on January 10, 2012

New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes

scientific article published in July 2011

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

scientific article published on 30 April 2016

Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression.

scientific article

Obesity and thyroid cancer: is leptin the (only) link?

scientific article published on August 2013

PI3K blockage synergizes with PLK1 inhibition preventing endoreduplication and enhancing apoptosis in anaplastic thyroid cancer

scientific article published on 19 September 2018

PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway

scientific article published in October 2002

PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation

scientific article

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

scientific article

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

scientific article published on 01 February 2001

Pten dose dictates cancer progression in the prostate

scientific article

Pten is essential for embryonic development and tumour suppression

scientific journal article

Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis

scientific article published in February 2007

Role of Dok-1 and Dok-2 in leukemia suppression

scientific article

SGK1: The Dark Side of PI3K Signaling

scientific article

Somatic acquisition and signaling of TGFBR1*6A in cancer

scientific article

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

scientific article published in June 2005

Structural and functional organization of the human endogenous retroviral ERV9 sequences

scientific article published on November 1, 1992

The PLK1 Inhibitor GSK461364A Is Effective in Poorly Differentiated and Anaplastic Thyroid Carcinoma Cells, Independent of the Nature of Their Driver Mutations ⬇️

scientific article published on July 25, 2013

Three-dimensional nuclear telomere architecture changes during endometrial carcinoma development

scientific article published on 30 April 2013

Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT

scientific article published on 01 September 2007

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