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List of works by John A. Williams

A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini ⬇️

scientific article published on September 11, 1998

A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini.

scientific article published on 2 March 2005

A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase.

scientific article

Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice

scientific article

Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation.

scientific article published on 10 June 2013

Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells

scientific article

Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin

scientific article published on 12 November 2012

CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini.

scientific article

CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth

scientific article

CCK-induced pancreatic growth is not limited by mitogenic capacity in mice

scientific article

Calcineurin is required for translational control of protein synthesis in rat pancreatic acini

scientific article published on 24 March 2004

Calcineurin mediates pancreatic growth in protease inhibitor-treated mice

scientific article published on 18 December 2003

Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth

scientific article published on 01 April 2006

Can too much acid sour your pancreas?

scientific article published on 29 July 2009

Catharanthine: a novel stimulator of pancreatic enzyme release

scientific article published on 01 September 1978

Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo

scientific article

Cholecystokinin stimulates formation of shc-grb2 complex in rat pancreatic acinar cells through a protein kinase C-dependent mechanism.

scientific article published on October 1996

Cholecystokinin stimulates heat shock protein 27 phosphorylation in rat pancreas both in vivo and in vitro

scientific article published on 01 April 1997

Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling ⬇️

scientific article published on June 11, 2013

Conversion to Ca(2+)-independent form of Ca2+/calmodulin protein kinase II in rat pancreatic acini

scientific article published on 01 February 1994

Do insulin and the insulin like growth factors (IGFs) stimulate growth of the exocrine pancreas?

scientific article published in January 1987

Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini

scientific article published on 30 September 2003

EPI64B Acts as a GTPase-activating Protein for Rab27B in Pancreatic Acinar Cells ⬇️

scientific article published on May 13, 2013

Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis

scientific article published on 30 March 2006

Effect of extracellular K+ concentration on resting potential, caerulein-induced depolarization and amylase release from mouse pancreatic acinar cells

scientific article published on August 29, 1977

Effects of cytochalasin B on pancreatic acinar cell structure and secretion.

scientific article published on April 1977

Effects of high concentrations of secretagogues on the morphology and secretory activity of the pancreas: A role for microfilaments ⬇️

scientific article published on January 1, 1982

Effects of membrane stabilizers on pancreatic amylase release ⬇️

scientific article published on May 6, 1977

Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice

scientific article published on 12 February 2004

Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA.

scientific article

Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. ⬇️

scientific article published on February 2016

Global topology analysis of pancreatic zymogen granule membrane proteins

scientific article published on 04 August 2008

Glucagon-like peptide-1 receptor is present in pancreatic acinar cells and regulates amylase secretion through cAMP.

scientific article

Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen granules is involved in calcium-regulated amylase secretion

scientific article published on 01 June 1997

Hyperthermia induces multiple pancreatic heat shock proteins and protects against subsequent arginine-induced acute pancreatitis in rats

scientific article published in January 2002

Identification of Rab 5 but not Rab 3A in rat pancreatic zymogen granule membranes

scientific journal article

Induction of early response genes in trypsin inhibitor-induced pancreatic growth

scientific article published on 09 November 2006

International symposium: mechanism of pancreatitis--between bedside and laboratory

scientific article published in May 2002

Intra- and intercellular calcium signaling in human neuroepithelioma cells.

scientific article

Intracellular uptake and α-amylase and lactate dehydrogenase releasing actions of the divalent cation ionophore A23187 in dissociated pancreatic acinar cells ⬇️

scientific article published on April 22, 1977

Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo

scientific article published on 01 March 1996

Localization of ATP-dependent calcium transport activity in mouse pancreatic microsomes

scientific article published on 01 January 1983

Molecular characterization of the endoplasmic reticulum: insights from proteomic studies

scientific article

Multiple effects of Na+ removal on pancreatic secretion in vitro ⬇️

scientific article published on January 1, 1980

Nucleotides regulate the binding affinity of the recombinant type A cholecystokinin receptor in CHO K1 cells

scientific article published on 01 February 1996

Organellar proteomics: analysis of pancreatic zymogen granule membranes

scientific article published on 08 November 2005

Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis

scientific article published in July 2004

Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice.

scientific article published in January 1987

Profiling CCK-mediated pancreatic growth: the dynamic genetic program and the role of STATs as potential regulators ⬇️

scientific article published on October 18, 2011

Proglumide (gastrin and cholecystokinin receptor antagonist) inhibits insulin secretion in vitro

scientific article published on 01 March 1986

Protein phosphatase inhibitors potentiate Ca2+/calmodulin-dependent protein kinase II activity in rat pancreatic acinar cells.

scientific article

Proteomics as a systems approach to pancreatitis.

scientific article published on August 2013

Purification and Characterization of a Novel Physiological Substrate for Calcineurin in Mammalian Cells ⬇️

scientific article published on August 28, 1998

Purification and identification of a 28-kDa calcium-regulated heat-stable protein. A novel secretagogue-regulated phosphoprotein in exocrine pancreas

scientific article published on 01 December 1996

Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas

scientific journal article

Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis

scientific journal article

Rap1 activation plays a regulatory role in pancreatic amylase secretion.

scientific article published on 24 June 2008

Rat pancreatic nucleoside diphosphate kinase, a novel regulator of cholecystokinin receptor affinity. Cloning and expression

scientific article published on 01 March 1994

Receptor biology and signal transduction in pancreatic acinar cells.

scientific article

Receptor-mediated signal transduction pathways and the regulation of pancreatic acinar cell function.

scientific article published on September 2008

Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells

scientific article

Regulation of acinar cell function in the pancreas.

scientific article published on September 2010

Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion

scientific article published on 26 May 2005

Secretin is not necessary for exocrine pancreatic development and growth in mice.

scientific article published on 18 August 2011

Small G proteins as key regulators of pancreatic digestive enzyme secretion.

scientific article published on 16 December 2008

Studies on a possible pituitary effect of monoamines on luteinizing hormone release in ovariectomized rats

scientific article published on 01 September 1980

The effect of the ionophore A23187 on amylase release, cellular integrity and ultrastructure of mouse pancreatic acini ⬇️

scientific article published on January 17, 1978

The nobel pancreas: a historical perspective.

scientific article published on June 2013

Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells

scientific article published on 01 August 1994

Zymogen granules of mouse parotid acinar cells are acidified in situ in an ATP-dependent manner

scientific article published on 01 July 1988

c-Jun/AP-1 is required for CCK-induced pancreatic acinar cell dedifferentiation and DNA synthesis in vitro.

scientific article

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