List of works by Ross A. McKinnon

A Fragment-Based Approach for the Computational Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes.

scientific article published on 19 August 2016

A functional screen with metformin identifies microRNAs that regulate metabolism in colorectal cancer cells

scientific article published on 21 February 2022

A novel approach for the simultaneous quantification of 18 small molecule kinase inhibitors in human plasma: A platform for optimised KI dosing

scientific article

A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.

scientific article published on 17 December 2014

Absence of type 1 11beta-hydroxysteroid dehydrogenase enzyme in koala liver.

scientific article published in January 2002

Baseline tumor size and survival outcomes in lung cancer patients treated with immune checkpoint inhibitors

scientific article published on 01 August 2019

Biosimilarity and Interchangeability: Principles and Evidence: A Systematic Review

scientific article published on 17 January 2018

CYP2C19 genotype has a greater effect on adverse cardiovascular outcomes following percutaneous coronary intervention and in Asian populations treated with clopidogrel: a meta-analysis

scientific article published on 25 September 2014

Characterisation of tolbutamide hydroxylase activity in the common brushtail possum, (Trichosurus vulpecula) and koala (Phascolarctos cinereus): inhibition by the eucalyptus terpene 1,8-cineole

scientific article published on 01 December 2000

Cloning and expression of koala (Phascolarctos cinereus) liver cytochrome P450 CYP4A15.

scientific article

Cloning and expression of koala (Phascolarctos cinereus) liver cytochrome P450 reductase

scientific article published in July 2009

Combination breast cancer chemotherapy with doxorubicin and cyclophosphamide damages bone and bone marrow in a female rat model

scientific article

Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats

scientific article published on 9 June 2015

Comparison data sets for benchmarking QSAR methodologies in lead optimization

scientific article published in July 2009

Comparison of linear and nonlinear classification algorithms for the prediction of drug and chemical metabolism by human UDP-glucuronosyltransferase isoforms

scientific article published on November 2003

Complementary and alternative medicines and dietary interventions in multiple sclerosis: what is being used in South Australia and why?

scientific article published on 21 April 2009

Computational Prediction of the Site(s) of Metabolism and Binding Modes of Protein Kinase Inhibitors Metabolized by CYP3A4

scientific article published on 22 March 2019

Cooperative regulation of intestinal UDP-glucuronosyltransferases by CDX2 and HNF4α is mediated by a novel composite regulatory element

scientific article published on 8 March 2018

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

scientific journal article

Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver

scientific article published on 01 December 2000

Cytochrome P450 CYP3A in marsupials: cloning and characterisation of the second identified CYP3A subfamily member, isoform 3A78 from koala (Phascolarctos cinereus).

scientific article published on 23 July 2011

Cytochrome P450 structure-function: insights from molecular dynamics simulations

scientific article

Cytochrome P450: evolution and functional diversity.

scientific article published on January 1994

Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma

scientific article published on 21 December 2018

Effect of early adverse events resulting in ado-trastuzumab emtansine dose adjustments on survival outcomes of HER2+ advanced breast cancer patients

scientific article published on 09 August 2019

Effectiveness of the Pharmacist-Involved Multidisciplinary Management of Heart Failure to Improve Hospitalizations and Mortality Rates in 4630 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

scientific article published on 24 July 2019

Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells.

scientific article

Exploration of the perceptions, barriers and drivers of pharmacogenomics practice among hospital pharmacists in Adelaide, South Australia

scientific article published on 10 September 2013

Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials

scientific article published on 12 August 2014

Flavonoids from the leaves and stems of Dodonaea polyandra: a Northern Kaanju medicinal plant

scientific article

Function and localization of cytochromes P450 involved in the metabolic activation of food-derived heterocyclic amines

scientific article published on 01 January 1995

Generic substitution in the treatment of epilepsy: patient attitudes and perceptions

scientific article published on 07 December 2012

Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance.

scientific article

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

scientific article published on February 2016

Hepatic cytochrome P450 enzymes belonging to the CYP2C subfamily from an Australian marsupial, the koala (Phascolarctos cinereus).

scientific article

Hepatic microsomal enzyme activity in the koala and tammar wallaby: high 17beta-hydroxysteroid oxidoreductase activity in koala liver microsomes

scientific article published on 01 May 1999

Hepatic nuclear receptor PPARalpha in the koala (Phascolarctos cinereus): cloning and molecular characterisation

scientific article published on 03 May 2007

Human thiopurine methyltransferase: no evidence of activation by its substrates.

scientific article published in January 1998

Identification and cloning of two forms of liver peroxisomal fatty Acyl CoA Oxidase from the koala (Phascolarctos cinereus).

scientific article published in May 2003

Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review

scientific article published on 25 August 2015

In silico insights: chemical and structural characteristics associated with uridine diphosphate-glucuronosyltransferase substrate selectivity

scientific article published in November 2003

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.

scientific article published on 14 July 2016

Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells

scientific article published on 20 March 2015

Induction of human UDP-Glucuronosyltransferase 2B7 gene expression by cytotoxic anticancer drugs in liver cancer HepG2 cells.

scientific article

Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia

scientific article published on 5 January 2017

Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective

scientific article published on 5 August 2015

Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective

scientific article published on 03 August 2015

Integrated care in cancer: What is it, how is it used and where are the gaps? A textual narrative literature synthesis.

scientific article published on 20 April 2017

Intergenic Splicing between Four AdjacentUGTGenes (2B15, 2B29P2, 2B17, 2B29P1) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions

scientific article published on 29 June 2018

Interventions Targeting the Prescribing and Monitoring of Vancomycin for Hospitalized Patients: A Systematic Review Protocol.

scientific article published on 27 October 2017

Interventions targeting the prescribing and monitoring of vancomycin for hospitalized patients: a systematic review with meta-analysis

scientific article published on 31 October 2018

Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy

scientific article

Junior doctors' preparedness to prescribe, monitor, and treat patients with the antibiotic vancomycin in an Australian teaching hospital.

scientific article published on 7 June 2017

Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure.

scientific article

Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization

scientific article published on 01 November 1991

Low adoption of pharmacogenetic testing: an exploration and explanation of the reasons in Australia

scientific article published on 01 May 2007

Low-molecular-weight heparin biosimilars: potential implications for clinical practice. Australian Low-Molecular-Weight Heparin Biosimilar Working Group (ALBW).

scientific article published on May 2014

Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency

scientific article

Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats.

scientific article published on 19 February 2016

Measurement of cytochrome P450 activation of xenobiotics using the Ames Salmonella test.

scientific article published in January 1991

Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours.

scientific article

Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer

scientific article

Metabolic differences in colon mucosal cells.

scientific article

Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids ⬇️

scientific article (publication date: April 1992)

Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer

scientific article

Micromanaging aerobic respiration and glycolysis in cancer cells

scientific article published on 06 February 2019

Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity

scientific article published in February 2004

Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells

scientific article published on 27 December 2016

Nuances to precision dosing strategies of targeted cancer medicines

scientific article published on 01 August 2020

Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9.

scientific article published in January 2004

PPAR-alpha cloning, expression, and characterization

scientific article published in January 2013

Palliative care is everyone's business, including pharmacists

scientific article published on March 2013

Partial charge calculation method affects CoMFA QSAR prediction accuracy

scientific article published in March 2009

Pharmacogenomics in a Global World: A Roadmap for Australia, Prospects and Challenges

article

Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates

scientific article published in November 2002

Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity.

scientific article

Polyandric Acid A, a Clerodane Diterpenoid from the Australian Medicinal Plant Dodonaea polyandra, Attenuates Pro-inflammatory Cytokine Secretion in Vitro and in Vivo

article

Polymorphisms and haplotypes of the UDP-glucuronosyltransferase 2B7 gene promoter.

scientific article published on 21 February 2014

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.

scientific article

Possible role of cytochromes P450 in lupus erythematosus and related disorders.

scientific article

Predicting response and toxicity to immune checkpoint inhibitors using routinely available blood and clinical markers.

scientific article published on 24 August 2017

Prediction of metabolism by cytochrome P450 2C9: alignment and docking studies of a validated database of substrates

scientific article published in February 2008

Predictors of Long-Term Disease Control and Survival for HER2-Positive Advanced Breast Cancer Patients Treated With Pertuzumab, Trastuzumab, and Docetaxel

scientific article published on 22 August 2019

Premenstrual syndrome and spironolactone

scientific article published on 01 November 1991

Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii) ⬇️

scientific article published on September 6, 2010

Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines

scientific article published on 10 July 2015

Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in prostate cancer cells involves canonical and non-canonical target sites

scientific article published on 24 January 2018

Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells.

scientific article published on 7 April 2017

Reply: Comment on 'Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal-antibody therapy for RAS wild-type metastatic colorectal cancer'.

scientific article published on 10 September 2015

Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse

scientific article published on 01 June 1998

Role of the Pharmacist for Improving Self-care and Outcomes in Heart Failure

scientific article published on 23 February 2017

Safety considerations of biosimilars

scientific article published on 5 December 2016

Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice

scientific article published on 01 November 1997

Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans

scientific article

Sustained improvement in vancomycin dosing and monitoring post-implementation of guidelines: Results of a three-year follow-up after a multifaceted intervention in an Australian teaching hospital.

scientific article published on 13 October 2017

The Routine Clinical use of Pharmacogenetic Tests: What it Will Require?

scientific article published on 24 February 2017

The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms

scientific article published on 01 April 2019

The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism

scientific article published on 21 October 2019

The effect of the UGT1A1*28 allele on survival after irinotecan-based chemotherapy: a collaborative meta-analysis

scientific article published on 08 April 2014

The effects of Eucalyptus terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARalpha) in the common brush tail possum (Trichosurus vulpecula).

scientific article published in October 2003

The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila.

scientific article published in August 2005

The impact of a pilot continuing professional development module on hospital pharmacists' preparedness to provide contemporary advice on the clinical use of vancomycin

scientific article

The importance of local chemical structure for chemical metabolism by human uridine 5'-diphosphate-glucuronosyltransferase.

scientific article published in November 2006

The role and utility of measuring red blood cell methotrexate polyglutamate concentrations in inflammatory arthropathies--a systematic review.

scientific article

Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases.

scientific article published on July 2004

Transcriptional regulation of human UDP-glucuronosyltransferase genes.

scientific article

Xenobiotic metabolism in Australian marsupials.

scientific article

miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells

scientific article

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