List of works - Andy Mercer

A Broad-Spectrum Chemokine-Binding Protein of Bovine Papular Stomatitis Virus Inhibits Neutrophil and Monocyte Infiltration in Inflammatory and Wound Models of Mouse Skin.

scientific article

A comparison of the anti-inflammatory and immuno-stimulatory activities of orf virus and ovine interleukin-10.

scientific article published on December 2002

A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus

scientific article

A truncated two-alpha-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex.

scientific article published on 4 March 2009

Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors

scientific article

Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway

scientific article

Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2.

scientific article published in March 2007

Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11.

scientific article

Characterization of immunostimulatory components of orf virus (parapoxvirus ovis).

scientific article

Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation

scientific article

Conservation and variation in orf virus genomes.

scientific article

Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins.

scientific article published on 4 March 2009

Conservation of gene structure and arrangement between vaccinia virus and orf virus.

scientific article published on July 1993

Conservation of plasmids among Escherichia coli K1 isolates of diverse origins.

scientific article published on December 1984

Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site.

scientific article published on March 2003

Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae)

scientific article

Cytokines and their inhibitors in orf virus infection

scientific article published in November 1996

Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep

scientific article published on 24 January 2017

Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus

scientific article published in June 2012

Development of orf virus as a bifunctional recombinant vaccine: surface display of Echinococcus granulosus antigen EG95 by fusion to membrane structural proteins

scientific article published on 12 November 2011

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.

scientific article published on 23 December 2014

F-box-like domains are present in most poxvirus ankyrin repeat proteins

scientific article

How viruses affect the cell cycle through manipulation of the APC/C.

scientific article published on 20 June 2012

Identification and characterization of an orf virus homologue of the vaccinia virus gene encoding the major envelope antigen p37K.

scientific article published on August 1994

In vitro recognition of an orf virus early promoter in a vaccinia virus extract

scientific article published in January 1992

In vivo recognition of orf virus early transcriptional promoters in a vaccinia virus recombinant

scientific article published on April 1, 1992

Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models

scientific article

Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus

scientific article published in July 2003

Induction of bacteremia in newborn rats by Escherichia coli K1 is correlated with only certain O (lipopolysaccharide) antigen types.

scientific article

Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor

scientific article published on 01 July 2007

Investigation of orf virus structure and morphogenesis using recombinants expressing FLAG-tagged envelope structural proteins: evidence for wrapped virus particles and egress from infected cells

scientific article published in March 2009

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

scientific article

Lack of cross-protection between vaccinia virus and orf virus in hysterectomy-procured, barrier-maintained lambs

scientific article

Lipopolysaccharide, capsule, and fimbriae as virulence factors among O1, O7, O16, O18, or O75 and K1, K5, or K100 Escherichia coli.

scientific article published on January 1984

Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin

scientific article published on 23 May 2007

Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10.

scientific article published in November 2006

Molecular genetic analysis of orf virus: a poxvirus that has adapted to skin

scientific article

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

scientific article

Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring

scientific article published on May 2014

Orf virus IL-10 reduces monocyte, dendritic cell and mast cell recruitment to inflamed skin

scientific article

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

scientific article

Orf virus and vaccinia virus do not cross-protect sheep

scientific article

Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex

scientific article published on 8 September 2010

Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2.

scientific article published on February 2000

Orf virus immuno-modulation and the host immune response

scientific article published in September 2002

Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway

scientific article

Orf virus interleukin-10 and vascular endothelial growth factor-E modulate gene expression in cultured equine dermal fibroblasts.

scientific article published on 22 August 2016

Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation

scientific article published on June 2007

Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model

scientific article published on 4 March 2009

Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells

scientific article published in May 2003

Ovine diseases. Orf.

scientific article

PARAPOXVIRUSES (POXVIRIDAE)

Parapoxvirus

Parapoxvirus of red deer in New Zealand encodes a variant of viral vascular endothelial growth factor

scientific article published on 15 November 2006

Parapoxvirus of red deer: evidence for its inclusion as a new member in the genus parapoxvirus.

scientific article

Persistent pseudocowpox virus infection of the skin of a foot in a cat.

scientific article published on 28 February 2013

Phylogenetic analysis of the large family of poxvirus ankyrin-repeat proteins reveals orthologue groups within and across chordopoxvirus genera

scientific article

Poxviral ankyrin proteins

scientific article

Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes

scholarly article

Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range function

scientific article published on 11 February 2009

Pseudocowpox virus encodes a homolog of vascular endothelial growth factor

scientific article published in January 2003

Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus

scientific article published in June 2004

Recurrent localised cutaneous parapoxvirus infection in three cats

scientific article published on 01 August 2008

Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2.

scientific article published in March 2007

Sequence analysis of the inverted terminal repetition in the genome of the parapoxvirus, orf virus.

scientific article published on June 1990

Sequence and transcriptional analysis of a near-terminal region of the orf virus genome.

scientific article published on January 1995

Sequence and transcriptional analysis of an orf virus gene encoding ankyrinlike repeat sequences ⬇️

scientific article published on February 1, 1995

Short-term treatment of equine wounds with orf virus IL-10 and VEGF-E dampens inflammation and promotes repair processes without accelerating closure

scientific article published on 29 September 2016

Six widespread bacterial clones among Escherichia coli K1 isolates.

scientific article published on January 1983

Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity

scientific article

The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1

scientific article published on 11 December 2007

The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo

scientific article published on September 2003

The establishment of a genetic map of orf virus reveals a pattern of genomic organization that is highly conserved among divergent poxviruses.

scientific article published on October 1995

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

scientific article published on 27 January 2010

The immune and inflammatory response to orf virus.

scientific article published on June 1997

The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon-inducible, double-stranded RNA-dependent kinase

scientific article published in March 1998

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.

scientific article published on November 2009

The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein.

scientific article

The structure and cloning of orf virus DNA.

scientific article

The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses

scientific article

The vascular endothelial growth factor (VEGF)-E encoded by orf virus regulates keratinocyte proliferation and migration and promotes epidermal regeneration

scientific article published on 15 May 2012

Therapeutic immunomodulation using a virus--the potential of inactivated orf virus.

scientific article

Transcriptional repression of E-cadherin by human papillomavirus type 16 E6.

scientific article

Vaccinia virus as a vaccine delivery system for marsupial wildlife

scientific article

Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: intra-nasal vaccination

scientific article published on 04 December 2007

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

scientific article

Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens

scientific article published in Journal of Biological Chemistry

Viral vascular endothelial growth factor plays a critical role in orf virus infection.

scientific article published on November 2000

List of works by Andy Mercer

A Broad-Spectrum Chemokine-Binding Protein of Bovine Papular Stomatitis Virus Inhibits Neutrophil and Monocyte Infiltration in Inflammatory and Wound Models of Mouse Skin.

A comparison of the anti-inflammatory and immuno-stimulatory activities of orf virus and ovine interleukin-10.

A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus

A truncated two-alpha-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex.

Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors

Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway

Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2.

Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11.

Characterization of immunostimulatory components of orf virus (parapoxvirus ovis).

Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation

Conservation and variation in orf virus genomes.

Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins.

Conservation of gene structure and arrangement between vaccinia virus and orf virus.

Conservation of plasmids among Escherichia coli K1 isolates of diverse origins.

Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site.

Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae)

Cytokines and their inhibitors in orf virus infection

Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep

Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus

Development of orf virus as a bifunctional recombinant vaccine: surface display of Echinococcus granulosus antigen EG95 by fusion to membrane structural proteins

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.

F-box-like domains are present in most poxvirus ankyrin repeat proteins

How viruses affect the cell cycle through manipulation of the APC/C.

Identification and characterization of an orf virus homologue of the vaccinia virus gene encoding the major envelope antigen p37K.

In vitro recognition of an orf virus early promoter in a vaccinia virus extract

In vivo recognition of orf virus early transcriptional promoters in a vaccinia virus recombinant

Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models

Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus

Induction of bacteremia in newborn rats by Escherichia coli K1 is correlated with only certain O (lipopolysaccharide) antigen types.

Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor

Investigation of orf virus structure and morphogenesis using recombinants expressing FLAG-tagged envelope structural proteins: evidence for wrapped virus particles and egress from infected cells

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

Lack of cross-protection between vaccinia virus and orf virus in hysterectomy-procured, barrier-maintained lambs

Lipopolysaccharide, capsule, and fimbriae as virulence factors among O1, O7, O16, O18, or O75 and K1, K5, or K100 Escherichia coli.

Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin

Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10.

Molecular genetic analysis of orf virus: a poxvirus that has adapted to skin

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring

Orf virus IL-10 reduces monocyte, dendritic cell and mast cell recruitment to inflamed skin

Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

Orf virus and vaccinia virus do not cross-protect sheep

Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex

Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2.

Orf virus immuno-modulation and the host immune response

Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway

Orf virus interleukin-10 and vascular endothelial growth factor-E modulate gene expression in cultured equine dermal fibroblasts.

Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation

Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model

Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells

Ovine diseases. Orf.

PARAPOXVIRUSES (POXVIRIDAE)

Parapoxvirus

Parapoxvirus

Parapoxvirus of red deer in New Zealand encodes a variant of viral vascular endothelial growth factor

Parapoxvirus of red deer: evidence for its inclusion as a new member in the genus parapoxvirus.

Persistent pseudocowpox virus infection of the skin of a foot in a cat.

Phylogenetic analysis of the large family of poxvirus ankyrin-repeat proteins reveals orthologue groups within and across chordopoxvirus genera

Poxviral ankyrin proteins

Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes

Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range function

Pseudocowpox virus encodes a homolog of vascular endothelial growth factor

Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus

Recurrent localised cutaneous parapoxvirus infection in three cats

Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2.

Sequence analysis of the inverted terminal repetition in the genome of the parapoxvirus, orf virus.

Sequence and transcriptional analysis of a near-terminal region of the orf virus genome.

Sequence and transcriptional analysis of an orf virus gene encoding ankyrinlike repeat sequences ⬇️

Short-term treatment of equine wounds with orf virus IL-10 and VEGF-E dampens inflammation and promotes repair processes without accelerating closure

Six widespread bacterial clones among Escherichia coli K1 isolates.

Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity

The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1

The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo

The establishment of a genetic map of orf virus reveals a pattern of genomic organization that is highly conserved among divergent poxviruses.

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

The immune and inflammatory response to orf virus.

The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon-inducible, double-stranded RNA-dependent kinase

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.

The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein.