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List of works by Christine J Harrison

A cell line from Wilms' tumour with deletion in short arm of chromosome 11

scientific article published on 01 October 1987

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

scientific article

A diminutive chromosome 21 centromere in acute lymphoblastic leukemia

scientific article published on May 2006

A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1. ⬇️

scientific article published on 03 October 2016

A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device

scientific article published in February 2007

A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia.

scientific article published on 20 May 2010

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia.

scientific article published on 23 June 2014

A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin

scientific article published on 25 September 2008

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.

scientific article published on December 2016

A scanning electron microscopy study of double minutes from a human tumour cell line.

scientific article published in January 1987

A unique variant of ETV6/AML1 fusion in a child with acute lymphoblastic leukemia

scientific article published on 01 May 2003

AN INTERSTITIAL DELETION IN THE REARRANGED T-CELL RECEPTOR γCHAIN LOCUS IN A CASE OF T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA

scientific article published on 01 March 1995

Abnormal cytogenetic clones in patients with aplastic anaemia: response to immunosuppressive therapy

article

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.

scientific article published on 18 October 2012

Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia

scientific article published on 08 January 2010

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

scientific article published on 12 November 2009

Acute Lymphoblastic Leukaemia

scientific article published on 01 January 2011

Acute Lymphoblastic Leukemia

article

Acute lymphoblastic leukaemia.

scientific article

Acute monocytic leukaemia and t(2;6) (p21;q26) translocation

scientific article published on 01 January 1989

Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma

scientific article published on 01 September 2005

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

scientific article published on 01 November 2003

Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.

scientific article

Amplification of the ABL gene in T-cell acute lymphoblastic leukemia

article

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

scientific article

Analysis of ETV6/AML1 abnormalities in acute lymphoblastic leukaemia: incidence, alternative spliced forms and minimal residual disease value

article

Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy

scientific article published on 12 April 2011

Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

scientific article published in Nature Communications

BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia

scientific article published on 17 July 2012

Blood Spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease

scientific article

Burkitt's lymphoma

scientific article

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response.

scientific article published on 15 December 2016

Cell Surface Morphology After Trypsinisation Depends on Initial Cell Shape

scientific article published on 01 January 1979

Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells.

scientific article

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia

scientific article

Chromosomal evidence of a common stem cell in acute lymphoblastic leukemia and chronic granulocytic leukemia

article

Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature

scientific article published on May 2013

Chronic myeloid leukemia: reminiscences and dreams

scientific article

Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group

scientific article

Clinical relevance of failed and missing cytogenetic analysis in acute myeloid leukaemia

scientific article published on 23 January 2017

Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia

article

Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia.

scientific article

Complex chromosomal abnormalities in utero, 5 years before leukaemia*

scientific article published on 01 August 2004

Constitutional abnormalities of chromosome 21 predispose to iAMP21-acute lymphoblastic leukaemia

scientific article published on 30 January 2016

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

scientific article

Cytogenetic and genomic characterization of cell line ARH77.

scientific article published on February 2008

Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study

scientific article

Cytogenetics and molecular genetics of acute lymphoblastic leukemia.

scientific article

Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.

scientific article

Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.

scientific article

Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia

scientific article published on 01 March 2010

Cytogenetics of multiple myeloma: interpretation of fluorescence in situ hybridization results

scientific article published on 01 March 2003

Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia.

scientific article

Del (9q) AML: clinical and cytological characteristics and prognostic implications

scientific article published in April 2005

Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia

article

Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma

scientific article published on 06 July 2006

Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia

scientific article published on 05 May 2016

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

scientific article published on 24 November 2010

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

scientific article published on 29 July 2009

Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia

scientific article published on 01 April 2005

Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission

article

Disruption of ETV6 in intron 2 results in upregulatory and insertional events in childhood acute lymphoblastic leukaemia

scientific article published in November 2007

Distinct patterns of gained chromosomes in high hyperdiploid acute lymphoblastic leukemia with t(1;19)(q23;p13), t(9;22)(q34;q22) or MLL rearrangements

scientific article published on 11 September 2012

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

scientific article

EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications

scientific article published on 12 February 2016

ETV6/RUNX1 fusion at diagnosis and relapse: Some prognostic indications

article

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia

scientific article

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia

scientific article

Evaluation of multiplex ligation-dependent probe amplification as a method for the detection of copy number abnormalities in B-cell precursor acute lymphoblastic leukemia

scientific article published on 01 December 2010

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

scientific article

Fluorescence In Situ Hybridization Analysis of Masked (8;21)(q22;q22) Translocations

article

Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia

scientific article

Frequent upregulation of MYC in plasma cell leukemia

scientific article published in July 2009

Functional studies of bone marrow haemopoietic and stromal cells in the myelodysplastic syndrome (MDS)

scientific article published on 01 May 1990

Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features ⬇️

scientific article published on March 18, 2013

Genetic aberrations in paediatric acute leukaemias and implications for management of patients.

scientific article published on 07 May 2010

Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations

scientific article published on 30 September 2014

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia ⬇️

scientific article published on 9 April 2018

Genomic Analysis Drives Tailored Therapy in Poor Risk Childhood Leukemia ⬇️

scientific article published on August 14, 2012

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia ⬇️

scientific article published on April 28, 2011

HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention

scientific article published on 12 July 2007

Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy

scientific article

Heterogeneity of VH–JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL

article

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

scientific article published on 16 October 2008

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome.

scientific article published on 19 December 2013

Hyperdiploidy with 49–65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome

scientific article published on 01 July 2013

Hyperfibrotic myelodysplasia

scientific article

IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome

scientific article

IGH@ translocations co-exist with other primary rearrangements in B-cell precursor acute lymphoblastic leukemia.

scientific article

IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia

scientific article

IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL.

scientific article

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.

scientific article published on 23 August 2013

Influence of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the susceptibility of K562 to natural cytotoxicity: evidence for clonal variation in differentiation-induced changes of lytic sensitivity

scientific article

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

scientific article published on 26 May 2016

Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study

scientific article

Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle

scientific article published in April 2007

Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia

article

Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?

scientific article published on 01 January 2004

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial

scientific article

Key pathways as therapeutic targets

article

Localization of the estrogen receptor locus (ESR) to chromosome 6q25.1 by FISH and a simple post-FISH banding technique.

scientific article published on July 1993

Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor

scientific article published on 2 May 2013

Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia

scientific article published on 14 August 2012

MLL translocations with concurrent 3' deletions: interpretation of FISH results

scientific article published in November 2004

MYELODYSPLASIA PRESENTING AS AUTOIMMUNE HAEMOLYTIC ANAEMIA

scientific article published on 01 September 1991

Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia

scientific article

Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia

scientific article published in May 2007

Molecular tracking of leukemogenesis in a triplet pregnancy.

scientific article published on July 2001

Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study

scientific article published on 13 February 2007

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

scientific article published in August 2008

New Genetics and Diagnosis of Childhood B-Cell Precursor Acute Lymphoblastic Leukemia ⬇️

scientific article published on June 22, 2011

No chromosome arm unturned: in memory of Roland Berger 1934-2012.

scientific article published in February 2014

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

scientific article published on 01 April 2005

Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.

scientific article

Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia

scientific article published on 26 June 2003

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

scientific article published on 22 March 2012

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia

scientific article published in May 2007

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia.

scientific article

PHF6 mutations in T-cell acute lymphoblastic leukemia

scientific article (publication date: 14 March 2010)

Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group.

scientific article

Philadelphia-positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia

scientific article published on 01 June 1986

Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins.

scientific article published on November 2003

Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21).

scientific article published on 9 November 2006

Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial

scientific article published on 19 April 2010

Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study

scientific article

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition

scientific article published on 27 August 2015

RECONSTITUTION OF HAEMOPOIETIC SYSTEM WITH AUTOLOGOUS MARROW TAKEN DURING RELAPSE OF ACUTE MYELOBLASTIC LEUKAEMIA AND GROWN IN LONG-TERM CULTURE

scientific article published in The Lancet

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

scientific article

Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia.

scientific article published on 17 March 2015

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

scientific article published on 12 April 2010

Residual Ph−cells in chronic myeloid leukemia: Detection and usefulness

scientific article published on 01 May 1993

Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 tr

scientific article published on 12 August 2013

Scanning electron microscopy of the G-banded human karyotype

scientific article published on 01 July 1981

Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome

scientific article published on 01 April 2004

Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia

scientific article

Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601.

scientific article published on 15 January 2009

Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172).

scientific article published in January 2004

T cell non-Hodgkin's lymphoma with uveitis, pancreatitis, digital gangrene and multiple chromosomal abnormalities.

scientific article

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

scientific article (publication date: October 2015)

Targeting signaling pathways in acute lymphoblastic leukemia: new insights

scientific article

The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A ⬇️

scientific article

The Eighth International Childhood Acute Lymphoblastic Leukemia Workshop ('Ponte di legno meeting') report: Vienna, Austria, April 27-28, 2005.

scientific article published in January 2006

The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: a valuable resource for patient management. Annotation

scientific article published on 01 April 2001

The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial

scientific article published on 24 January 2013

The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1.

scientific article

The genetics of childhood acute lymphoblastic leukaemia

article

The importance of cytogenetics and associated molecular techniques in the management of patients with leukaemia

scientific article published in January 1998

The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc

scientific article published on 01 December 1994

The management of patients with leukaemia: the role of cytogenetics in this molecular era.

scientific article

The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.

scientific article published on 06 May 2015

The prognostic significance of trisomy 4 in acute myeloid leukaemia is dependent on age and additional abnormalities

scientific article published on 25 July 2016

The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

scientific article

Three cases of the myelodysplastic syndrome with pericentric inversion of chromosome 16

scientific article published on 01 September 1993

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

article

Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia

scientific article published on 01 August 2001

Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis

scientific article published on 01 May 2002

Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.

scientific article published in May 2002

Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

scientific article

Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials

scientific article published on 01 December 2005

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.

scientific article published on 28 June 2017

Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia

scientific article

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

scientific article

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

scientific article

t(14;19)(q32;q13): A recurrent translocation in B-cell precursor acute lymphoblastic leukemia

scientific article published on 01 January 2004

t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

scientific article

t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients

scientific article

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