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Authors whose works are in public domain in at least one jurisdiction

List of works by Bruno Lomonte

12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages

scientific article published on 04 December 2019

A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A2 on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A2α

scientific article published on 10 June 2020

A Lys49 phospholipase A(2) homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line

scientific article

A Lys49 phospholipase A2, isolated from Bothrops asper snake venom, induces lipid droplet formation in macrophages which depends on distinct signaling pathways and the C-terminal region

scientific article published on 24 December 2012

A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling.

scientific article

A Representative GIIA Phospholipase A<sub>2</sub> Activates Preadipocytes to Produce Inflammatory Mediators Implicated in Obesity Development

scientific article published on 24 November 2020

A Secreted Phospholipase A2 Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State

scientific article published on 06 September 2019

A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis.

scientific article published on 14 June 2018

A bright future for integrative venomics

scientific article published on 2 November 2015

A catalytically-inactive snake venom Lys49 phospholipase A₂ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages

scientific article published on 14 February 2013

A constant area monolayer method to assess optimal lipid packing for lipolysis tested with several secreted phospholipase A2

scientific article published on 04 June 2015

A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina

scientific article published on 27 April 2018

A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).

scientific article published on January 1989

A novel pentameric phospholipase A 2 myotoxin (PophPLA 2 ) from the venom of the pit viper Porthidium ophryomegas

scholarly article by Julio Vindas published in October 2018

A novel pentameric phospholipase A myotoxin (PophPLA) from the venom of the pit viper Porthidium ophryomegas

scientific article published in 2018

A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis

article

A structure-based proposal for a comprehensive myotoxic mechanism of phospholipase A2-like proteins from viperid snake venoms

scientific article published on 30 September 2014

Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions

scientific article published on 23 October 2007

Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms

scientific article published on 01 April 2020

Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A(2).

scientific article published in October 2005

Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro.

scientific article published on April 1994

Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model

scientific article published on 16 July 2010

Aggregation behavior of sodium 3-(octyloxy)-4-nitrobenzoate in aqueous solution

Amino acid sequence and biological characterization of BlatPLA₂, a non-toxic acidic phospholipase A₂ from the venom of the arboreal snake Bothriechis lateralis from Costa Rica

scientific article

An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-κB, p38MAPK, and PKC in macrophages

scientific article

An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies

scientific article published in May 1993

An acidic phospholipase A₂ with antibacterial activity from Porthidium nasutum snake venom

scientific article

An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes

scientific article published on 01 August 1992

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

scientific article published on 24 June 2020

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action

scientific article published on December 2003

Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations

scientific article published on 20 February 2006

Antibodies toHelicobacter pyloriin dyspeptic patients, asymptomatic adults, and children from Costa Rica

scholarly article by GISELLE Bartels et al published January 1995 in Acta Pathologica et Microbiologica Scandinavica

Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)

scientific article published on 01 January 1987

Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols

scientific article published in January 2005

Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region

scientific article published in June 2005

Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms

scientific article published on 16 November 2006

Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities

scientific article published on 30 September 2010

Antivenomics: A Proteomics Tool for Studying the Immunoreactivity of Antivenoms

Antivenoms for Snakebite Envenomings ⬇️

scientific article published on October 1, 2011

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

scientific article published on 23 March 2017

Assessing Target Specificity of the Small Molecule Inhibitor MARIMASTAT to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling

scientific article published in 2024

Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics

scientific article

Autocatalytic acylation of phospholipase-like myotoxins.

scientific article published in April 1995

Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom--synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region

scientific article published in April 1998

Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2.

scientific article

Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper ⬇️

scientific article published on September 15, 1997

Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro

article

Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper

scientific article published on 16 December 2008

Biological and Proteolytic Variation in the Venom of Crotalus scutulatus scutulatus from Mexico

scientific article published on 8 January 2018

Biological and biochemical activities of Vipera berus (European viper) venom

scientific article published on 01 June 1993

Biological and structural characterization of crotoxin and new isoform of crotoxin B PLA(2) (F6a) from Crotalus durissus collilineatus snake venom

scientific article published in June 2007

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

scientific article

Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom

scientific article

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors.

scientific article published on May 2009

Cardiac effect induced by Crotalus durissus cascavella venom: morphofunctional evidence and mechanism of action

scientific article published on 22 November 2020

Catalytically inactive phospholipase A2homologue binds to vascular endothelial growth factor receptor-2 via a C-terminal loop region

scientific article published on 01 May 2008

Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A and mediates its toxic activity

scientific article published in Scientific Reports

Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action.

scientific article published on September 2008

Characterization of a basic phospholipase A2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarará chica) from Argentina

article

Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii

scientific article published on 10 March 2016

Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect

scientific article published on 01 August 1994

Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens

scientific article published on 21 July 2018

Comparative analysis of membranotropic properties of various phospholipases A2 from venom of snakes of the family viperidae

scientific article

Comparative biochemical study of the venoms of scorpions Tityus asthenes and Centruroides edwardsii from Costa Rica

scientific article published on 01 April 2020

Comparative characterization and synergism between two basic phospholipases A2 from Bothrops diporus snake venom

scientific article published on 01 April 2020

Comparative characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression

scientific article published on 30 May 2020

Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms

scientific article published in September 2003

Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro

scientific article published on January 1999

Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom

scientific article published on 8 September 2011

Comparative study of the edema-forming activity of costa rican snake venoms and its neutralization by a polyvalent antivenom

article

Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom

scientific article published on 01 February 2000

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions

scientific article published on 01 June 2001

Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles).

scientific article

Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico

scientific article

Computational biology in Costa Rica: the role of a small country in the global context of bioinformatics

scientific article

Correction to “Snake Venomics of Crotalus tigris: The Minimalist Toxin Arsenal of the Deadliest Nearctic Rattlesnake Venom. Evolutionary Clues for Generating a Pan-Specific Antivenom against Crotalid Type II Venoms”

scholarly article published in Journal of Proteome Research

Corrigendum to “Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment” published in Toxicon 54 (7), (2009), 1012–1028

scholarly article by Bruno Lomonte et al published June 2010 in Toxicon

Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

scientific article published on 22 April 2016

Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-secreted phospholipase A2 from snake venom

scientific article

Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping

scientific article published on 14 July 2017

Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative "myotoxic cluster".

scientific article

Crystallization of the Lys49 PLA2 homologue, myotoxin II, from the venom of Atropoides nummifer

scientific article published in December 2004

Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium

scientific article

Cytotoxicity of Lachesis muta muta snake (bushmaster) venom and its purified basic phospholipase A2 (LmTX-I) in cultured cells

scientific article

Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

scientific article published on 30 September 2021

Danger in the canopy. Comparative proteomics and bioactivities of the venoms of the South American palm pitviper Bothrops bilineatus subspecies bilineatus and smaragdinus, and antivenomics of B. b. bilineatus (Rondônia) venom against the Brazilian p

scientific article published on 18 July 2020

Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis

scientific article published on 11 July 2015

Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

scientific article published on 20 September 2018

Depletion of Complement Enhances the Clearance of Brucella abortus in Mice

scientific article published on 21 September 2018

Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms

scientific article published on 01 January 1987

Development of Nanobodies Against Hemorrhagic and Myotoxic Components of Bothrops atrox Snake Venom

scientific article published on 07 May 2020

Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species)

article

Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms.

scientific article

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

scientific article published in 2023

Discovery of cross-reactive and recyclable human monoclonal antibodies for new recombinant antivenoms

scientific article published on 01 April 2020

Dissociation of enzymatic and toxic activities by the use of antibodies

scientific article published on 01 January 1990

Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii.

scientific article published on 2 July 2016

Edema-forming activity of bushmaster (Lachesis muta stenophrys) and Central American rattlesnake (Crotalus durissus durissus) venoms and neutralization by a polyvalent antivenom

scientific article published on 01 January 1985

Editorial: Novel Immunotherapies Against Envenomings by Snakes and Other Venomous Animals

scientific article published on 22 May 2020

Effect of a recombinant Lys49PLA2 myotoxin and Lys49PLA2-derived synthetic peptides from Agkistrodon species on membrane permeability to water

scientific article published in August 2004

Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro.

scientific article

Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica

scientific article published on 01 January 1990

Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro.

scientific article published on December 1994

Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation

scientific article

Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum

article

Electrophoretic and immunochemical studies of Micrurus snake venoms

scientific article published on 01 June 1994

Envenomations by Bothrops and Crotalus snakes induce the release of mitochondrial alarmins

scientific article

Enzymatic labelling of snake venom phospholipase A2 toxins

scientific article published on 26 September 2019

Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability

scientific article published on 01 January 1990

Estudio comparativo de los venenos de serpiente Cascabel (Crotalus durissus durissus) de ejemplares adultos y recien nacidos

article

Estudio de la capacidad ofiofaga y la resistencia de la zopilota (Clelia clelia, Colubridae) de Costa Rica a los venenos de serpiente

scientific article published on 01 January 1982

Evaluacion de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica

scientific article published on 01 September 1995

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

scientific article published on 24 January 2017

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca

scientific article published in September 2016

Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs

scientific article published on 23 September 2005

First crotoxin-like phospholipase A(2) complex from a New World non-rattlesnake species: nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis

scientific article published on 28 November 2014

First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: Proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom

article

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

scientific article published on 22 June 2016

Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum

scientific article

Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom

scientific article published on 08 June 2020

Fungicidal activity of a phospholipase-A2-derived synthetic peptide variant against Candida albicans

scientific article published in September 2007

Genetic and toxinological divergence among populations of Tityus trivittatus Kraepelin, 1898 (Scorpiones: Buthidae) inhabiting Paraguay and Argentina

scientific article published on 14 December 2020

Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom

scientific article published on 07 April 2017

Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment

article

High-density peptide microarray exploration of the antibody response in a rabbit immunized with a neurotoxic venom fraction

scientific article

High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays

scientific article

Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice

scientific article published on 01 January 1989

Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture

article

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

scientific article published on 13 August 2019

Host response to Bothrops asper snake venom. Analysis of edema formation, inflammatory cells, and cytokine release in a mouse model

scientific article published on April 1993

Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration

scientific article published on 18 June 2008

Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants

scientific article published in May 2003

Identification of linear B-cell epitopes on myotoxin II, a Lys49 phospholipase A2 homologue from Bothrops asper snake venom ⬇️

scientific article published on June 4, 2012

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.

scientific article published on August 2000

Identification of the myotoxic site of the Lys49 phospholipase A(2) from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities

scientific article

Immunochemical characterization and role in toxic activities of region 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom

scientific article

Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies

scientific article published on 01 June 1994

Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A(2) from Bothrops asper snake venom

scientific article

Immunoenzymatic quantitation of antibodies to Bothrops asper myotoxins after polyvalent antivenom administration in mice

scientific article published on 01 January 1992

Immunoglobulin G and F(ab′)2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom

scientific article published on 01 November 1997

Immunohistochemical demonstration of the binding of Bothrops asper myotoxin to skeletal muscle sarcolemma

scientific article

Immunological cross-recognition and neutralization studies of Micrurus mipartitus and Micrurus dumerilii venoms by two therapeutic equine antivenoms

scientific article published on 11 September 2020

Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays

scientific article published on 28 February 2014

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

scientific article published in Nature Communications

Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops asper

scientific article published on 01 June 1992

Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin.

scientific article published in July 2005

Inhibition of the myotoxic activity of Bothrops asper myotoxin II in mice by immunization with its synthetic 13-mer peptide 115–129

scientific article published on 01 April 1999

Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2

scientific article published on 01 November 2003

Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle

scientific article published in May 2005

Innovative Immunization Strategies for Antivenom Development

article

Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom.

scientific article

Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies

scientific article published on 29 May 2013

Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profiles of hemolytic and non-hemolytic isoforms

scientific article

Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: identification of directly hemolytic phospholipases A2.

scientific article published in August 2014

Isolation and Characterization of a Myotoxic Phospholipase A2from the Venom of the Arboreal SnakeBothriechis(Bothrops)schlegeliifrom Costa Rica

scientific article published on 01 March 1997

Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom

scientific article published on 31 August 2012

Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom

scientific article published on 01 October 1992

Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus

scientific article

Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue

article

Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer

scientific article published on 01 January 1986

Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom

scientific article published on 01 January 1985

Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper)

scientific article published on 01 January 1990

Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization☆

scientific article published on 22 December 2009

Isolation of basic myotoxins from Bothrops Moojeni and Bothrops Atrox snake venoms

scientific article published on 01 January 1990

Isolation of bothrasperin, a disintegrin with potent platelet aggregation inhibitory activity, from the venom of the snake Bothrops asper.

scientific article published in March 2003

Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: Comparative characterization and synergism between Asp49 and Lys49 variants

scientific article published on 18 July 2019

Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae)

scientific article published on 26 September 2006

Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2.

scientific article published on 6 June 2016

Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species

article

Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom

scientific article published in December 1995

Lys49 myotoxins: Emerging insights into their modes of action

scientific article published on 01 April 2020

Lys‐49‐phospholipases A2 as active enzyme for β‐arachidonoyl phospholipid bilayer membranes ⬇️

scientific article published on 01 September 1997

Medicinal plants with inhibitory properties against snake venoms

scientific article

Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper

scientific article published on 19 April 2011

MipLAAO, a new L-amino acid oxidase from the redtail coral snake Micrurus mipartitus.

scientific article published on 8 June 2018

Mipartoxin-I, a novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae).

scientific article

Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From <i>Bothrops asper</i> Venom

scientific article published on 01 January 2021

Mortality due to Hymenoptera stings in Costa Rica, 1985-2006.

scientific article published in May 2009

Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A₂ myotoxins--distinct mechanisms of action

scientific article published on 12 July 2013

Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica

article

Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation

scientific article published in September 2005

Myotoxic and hemorrhagic effects of fractions obtained from the venom of lionfish (pterois volitans) in mice and identification of potentially toxic components

scientific article published on 01 April 2020

Myotoxic phospholipases A(2) in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.

scientific article

Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2.

scientific article published in February 1991

N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils

scientific article published on 21 March 2016

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

scientific article

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

scientific article

Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: contributions to understanding snakebite envenomings and their treatment

scientific article published on 24 March 2009

Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom

scientific article published on 01 January 1991

Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment

scientific article published in January 2005

Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia

article

Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom

scientific article

Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice

scientific article published on 01 May 1996

Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies

scientific article published on 01 March 1992

Neutralization of the cytolytic and myotoxic activities of phospholipases A 2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family

scientific article published on 01 April 1994

Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling.

scientific article

Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2

scientific article published on 14 November 2018

New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America

scientific article published on 01 April 2019

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

scientific article

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

scientific article published on 19 August 2020

Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: Phylogenetic relationships and characterization of Clarkitoxin-I-Mdum

scientific article published on 23 September 2019

Nucleolin internalizesBothrops asperLys49 phospholipase A2forming cell surface amyloid-like assemblies

Omics meets biology: application to the design and preclinical assessment of antivenoms

scientific article

Ontogenetic changes in the venom of Metlapilcoatlus nummifer, the mexican jumping viper

scientific article published on 26 June 2020

Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica

scientific article published on 01 January 1990

Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice

scientific article published on February 1986

Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation

scientific article

Pharmacokinetics of whole IgG equine antivenom: Comparison between normal and envenomed rabbits

scientific article published on 14 June 2006

Pharmacological activities of a toxic phospholipase a isolated from the venom of the snake Bothrops Asper

article

Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis

scientific article

Phospholipase A2 and inflammation

scientific article published on 01 April 1995

Phospholipase A2 myotoxins from Bothrops snake venoms

scientific article

Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?

scientific article published on December 1, 2011

Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins ⬇️

scientific article published on September 28, 2012

Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms

scientific article published on 4 November 2014

Pitfalls to avoid when using phage display for snake toxins.

scientific article

Potent virucidal activity against Flaviviridae of a group IIA phospholipase A2 isolated from the venom of Bothrops asper

scientific article published on 12 December 2019

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead

scientific article

Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays

scientific article published on 10 January 2013

Primary structures and partial toxicological characterization of two phospholipases A2 from Micrurus mipartitus and Micrurus dumerilii coral snake venoms.

scientific article published on 14 March 2017

Production and partial characterization of monoclonal antibodies to Bothrops asper (terciopelo) myotoxin

scientific article published in January 1988

Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

scientific article

Pros and cons of different therapeutic antibody formats for recombinant antivenom development

article

Protein-species quantitative venomics: looking through a crystal ball

scientific article

Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential

scientific article published on 13 January 2020

Proteolytic activity of snake venoms of Costa Rica on casein

scientific article published on 01 June 1983

Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase

scientific article

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).

scientific article

Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica

scientific article published on 23 September 2011

Proteomic and functional analyses of the venom of Porthidium lansbergii lansbergii (Lansberg's hognose viper) from the Atlantic Department of Colombia

scientific article

Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom

scientific article

Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia

scientific article published in August 2014

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus

scientific article published on 12 April 2018

Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica

scientific article published on 01 March 2019

Publisher Correction: In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

scientific article published in Nature Communications

Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom

scientific article published on 01 January 1995

Quantitation by enzyme-immunoassay of antibodies against bothrops myotoxins in four commercially-available antivenoms

scientific article published on 01 January 1991

Resurrexit, sicut dixit, alleluia. Snake venomics from a 26-year old polyacrylamide focusing gel

scientific article published on 02 October 2011

Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?

scientific article published on 16 September 2014

SImilar effectiveness of fab and f(ab′)2 antivenoms in the neutralization of hemorrhagic activity of Vipera berus snake venom in mice

scientific article published on 01 October 1996

Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach

scientific article published on 20 May 2016

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

article

Serum immunoglobulin levels in Cabécar and Guaymí Indians in Southeastern Costa Rica

scientific article published on 01 November 1987

Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice

scientific article

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management

scientific article published on 26 January 2011

Snake venom Lys49 myotoxins: From phospholipases A(2) to non-enzymatic membrane disruptors.

scientific article published on 03 March 2012

Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide

scientific article published in March 2004

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism

article

Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii

scientific article published on 30 April 2008

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

scientific article published on 21 January 2009

Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.

scientific article

Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose

scientific article published in August 2010

Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia

scientific article published on 22 January 2014

Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi

scientific article

Snake venomics of Crotalus tigris: the minimalist toxin arsenal of the deadliest Nearctic rattlesnake venom. Evolutionary Clues for generating a pan-specific antivenom against crotalid type II venoms [corrected]

scientific article

Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids.

scientific article published on 28 August 2015

Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins

scientific article published on 11 March 2015

Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America

scientific article

Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom

scientific article

Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis

Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights

scientific article published on 23 December 2011

Snake venomics, experimental toxic activities and clinical characteristics of human envenomation by Bothrocophias myersi (Serpentes: Viperidae) from Colombia

scientific article published on 01 April 2020

South American snake venom proteins antigenically related to Bothrops asper myotoxins

scientific article published on 01 January 1990

Standardization of assays for testing the neutralizing ability of antivenoms

article

Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

scientific article

Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom

scientific article published in June 2000

Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom.

scientific article published in January 2000

Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox

scientific article published in July 2004

Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus

scientific article published on 15 December 2006

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

scientific article published on 20 November 2019

Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue

scientific article

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom

scientific article published on 12 April 2006

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo

scientific article

Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from viperidae snake venoms: biomimetic activities and potential applications

scientific article published on January 2010

Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue

scientific article published on 29 August 2007

Systemic cytokine response in children bitten by snakes in Costa Rica

scientific article published in December 2001

The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes

scientific article published on 14 October 2009

The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: An intravital and electron microscopic study

scientific article published on 01 January 1994

The earless monitor lizard Lanthanotus borneensis - A venomous animal?

scientific article published on 25 November 2020

The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities

article

The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles

scientific article published on January 2009

The serum of newborn Clelia clelia (Serpentes: Colubridae) neutralizes the hemorrhagic action of Brothrops asper venom (Serpentes: Viperidae)

scientific article published on 01 November 1990

The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms

article

Three-finger toxins from the venom of Micrurus tschudii tschudii (desert coral snake): Isolation and characterization of tschuditoxin-I

scientific article published on 15 June 2019

Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?

scientific article published on 20 August 2009

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).

scientific article

Trends in snakebite envenomation therapy: scientific, technological and public health considerations

scientific article

Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom

scientific article published on 3 April 2014

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.

scientific article published on March 2000

Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect

scientific article published on 01 November 1999

Understanding structural and functional aspects of PII snake venom metalloproteinases: characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis

scientific article published on 21 January 2014

Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A2 and Cytotoxins

scientific article published on 07 May 2020

Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms

scientific article published on 23 April 2018

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development

scientific article published on 14 February 2015

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

scientific article published on 20 February 2020

Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): Composition, biochemical activities and in vivo toxicity for potential prey

scientific article published on 01 October 2019

Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin

scientific article published on 08 September 2018

Venom diversity in the Neotropical scorpion genus Tityus: Implications for antivenom design emerging from molecular and immunochemical analyses across endemic areas of scorpionism

scientific article published on 23 January 2020

Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin.

scientific article published on 05 May 2016

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A2 homologue and neutralization by two antivenoms

scientific article published on 01 June 2001

Venom variation in Bothrops asper lineages from north-western South America

scientific article published on 20 August 2020

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA₂ Dichotomy across Micrurus Venoms

scientific article

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).

scientific article published on 25 February 2011

Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon

scientific article

Venomics of the Central American Lyre Snake Trimorphodon quadruplex (Colubridae: Smith, 1941) from Costa Rica

scientific article published on 04 April 2020

Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models

scientific article published on 26 June 2020

Venomics of the colubrid snake Trimorphodon quadruplex from Costa Rica

scientific article published on 01 April 2020

Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics

scientific article

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.

scientific article published on 15 September 2016

Venoms, venomics, antivenomics

scientific article published on 20 March 2009

Why myotoxin-containing snake venoms possess powerful nucleotidases?

scientific article published on 19 December 2012

[Changes in the electrophoretic pattern of the venom of the bushmaster (Lachesis muta stenophrys) stored under various conditions]

scientific article published on 01 June 1985

[Scientific publications of Costa Rica in Science Citation Index bibliometric analysis of the period 1999-2001]

scientific article published on 01 September 2002

p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities

scientific article published in September 1993

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