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List of works by Gabriele Saretzki

A DNA damage checkpoint response in telomere-initiated senescence

scientific article (publication date: 13 November 2003)

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

scientific article

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

scientific article

Accelerated telomere shortening in fibroblasts after extended periods of confluency.

scientific article published on April 1998

Adult-onset, short-term dietary restriction reduces cell senescence in mice.

scientific article published on September 2010

Airway epithelial cell senescence in the lung allograft

scientific article published on 01 July 2008

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure. ⬇️

scientific article published on 15 September 2017

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism

scientific article published on 4 August 2014

BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

scientific article

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

scientific article published in May 2013

Cellular senescence in the development and treatment of cancer.

scientific article published on January 2010

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

scientific article

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

scientific article

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

scientific article

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease

scientific article published on April 2012

Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype.

scientific article published on 17 July 2014

Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium.

scientific article published on 30 April 2015

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells

scientific article published on 29 November 2007

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

scientific article published on 08 January 2007

Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts

scientific article published on 01 September 2005

Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study

scientific article published on 09 December 2020

Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.

scientific article published on 2 May 2008

Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress.

scientific article published on January 2014

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

scientific article

Feedback between p21 and reactive oxygen production is necessary for cell senescence

scientific article

Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism ⬇️

scientific article published on January 2, 2012

Human cell senescence as a DNA damage response.

scientific article

Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis.

scientific article published on 25 October 2015

Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.

scientific article published on 26 September 2017

Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

scientific article published on 01 April 2010

Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome

scientific article published on 01 October 1997

Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts

scientific article published on 15 July 2010

Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen

scientific article published on 01 August 2003

Implications of telomeres and telomerase in endometrial pathology

scientific article

Improvement of biological age by physical activity

scientific article published on 12 August 2014

Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress

scientific article published on 12 October 2016

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

scientific article

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

scientific article published on 01 September 1995

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

scientific article published on 01 April 2003

Mitochondria are required for pro-ageing features of the senescent phenotype.

scientific article

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

scientific article

Mitochondrial dysfunction and cell senescence: cause or consequence?

scientific article

Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis

scientific article

Molecular mechanisms of senescence in cell culture

scientific article

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

scientific article

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts ⬇️

scientific article published on February 25, 1998

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage

scientific article published on 20 August 2007

Replicative aging, telomeres, and oxidative stress

scientific article

Replikative Seneszenz als Alternsmodell: Die Rolle von oxidativem Streß und Telomerenverkürzung - eine übersicht

scientific article published on 01 April 1999

Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells ⬇️

scientific article published on October 1, 2001

SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis

scientific article published on 11 July 2013

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

scientific article published in November 2000

Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts

scientific article published in November 1998

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span

scientific article published on 12 February 2004

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

scientific article

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts

scientific article

Telomerase Activity is Downregulated Early During Human Brain Development.

scientific article published on 16 June 2016

Telomerase activity in cervical smears.

scientific article published in January 2001

Telomerase and mTOR in the brain: the mitochondria connection.

scientific article published on March 2017

Telomerase as a promising target for human cancer gene therapy.

scientific article

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

scientific article published on 11 March 2008

Telomerase inhibition as cancer therapy.

scientific article

Telomerase inhibition by induced expression of antisense RNA.

scientific article published on January 1998

Telomerase, mitochondria and oxidative stress.

scientific article published on 18 May 2009

Telomere length as a marker of oxidative stress in primary human fibroblast cultures

article

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3'-overhang

scientific article published in June 2004

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

scientific article published on September 1999

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult

scientific article

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

scientific article

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.

scientific article published on 17 October 2016

The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families ⬇️

scientific article published on September 6, 2010

The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

scientific article

The role of telomeres in Etoposide induced tumor cell death.

scientific article published on 13 September 2004

Tumour-cell apoptosis after cisplatin treatment is not telomere dependent

scientific article published on June 2006

Well-known signaling proteins exert new functions in the nucleus and mitochondria.

scientific article published on August 2010

hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines

article

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