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List of works by Paul T. Francis

'Traditional' pharmacotherapy may succeed in Alzheimer's disease

scientific article published on March 1, 1992

5-HT1B and other related serotonergic proteins are altered in APPswe mutation.

scientific article

A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease

scientific article published on 19 February 2011

A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media ⬇️

scientific article published on August 15, 1995

A pilot study of potential brain donor satisfaction and attitudes towards telephone assessment

scientific article

A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?

scientific article

Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors

scientific article published on 9 February 2007

Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia

scientific article published on 09 July 2019

Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease

scientific article

Altered NCAM expression associated with the cholinergic system in Alzheimer's disease.

scientific article published in January 2010

Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients

scientific article

Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

scientific article published on 24 May 2019

Amyloid beta concentrations in older people with Down syndrome and dementia

scientific article published on 24 December 2008

An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias

scientific article published on 11 August 2017

An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease.

scientific article

Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression ⬇️

scientific article published on January 1, 1993

Antipsychotic medication is associated with selective alterations in ventricular cerebrospinal fluid Aβ 40 and tau in patients with intractable unipolar depression

scientific article published on 9 February 2011

Apathy associated with neurocognitive disorders: Recent progress and future directions.

scientific article published on 27 June 2016

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.

scientific article published on 17 June 2014

Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies.

scientific article published on 30 October 2013

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

scientific article

Associations between ZnT3, tau pathology, agitation, and delusions in dementia

scientific article published on 01 June 2018

Brains for Dementia Research: The Importance of Cohorts in Brain Banking

scientific article published on 02 January 2019

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

scientific article published on 2 July 2012

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

scientific article

Changes in hippocampal SNAP-25 expression following afferent lesions

scientific article

Choline acetyltransferase activity in vascular dementia and stroke

scientific article published on 17 September 2009

Cholinergic and other neurotransmitter mechanisms in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies.

scientific article published on September 2007

Cholinergic imbalance in the multiple sclerosis hippocampus

scientific article

Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease.

scientific article published in January 2005

Cholinomimetics Increase Glutamate Outflow via an Action on the Corticostriatal Pathway: Implications for Alzheimer's Disease ⬇️

scientific article published on November 1, 1995

Chronic elevation of amyloid precursor protein in the neocortex or hippocampus of marmosets with selective cholinergic lesions.

scientific article

Clusterin associates specifically with Aβ40 in Alzheimer's disease brain tissue

scientific article

Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia

scientific article published on 8 October 2008

Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.

scientific article published on 18 January 2006

Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia

scientific article published on 30 November 2015

Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias.

scientific article published on 12 July 2013

Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden

scientific article

Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency.

scientific article published on 8 February 2016

Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia

scientific article published on 14 May 2014

Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

scientific article

Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease

scientific article published in January 2015

Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease

scientific article published in February 2004

Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease

scientific article published on 13 July 2010

Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease

scientific article published on 18 January 2017

Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease

scientific article published in August 2006

Dynamin protein in stroke and vascular dementia

scientific article

Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia

scientific article

Effect of psychotropic drugs on excitatory amino acids in patients undergoing psychosurgery for depression

scientific article published on May 1, 1992

Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions

scientific article published in July 2001

Factors affecting withdrawal and donation attrition in the brains for dementia research cohort

scientific article published on 12 September 2018

Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

article

Genetic variation in the 5-HT2A receptor and altered neocortical [3H] ketanserin binding in Alzheimer's disease.

scientific article

Genotyping of the Alzheimer’s Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort

scholarly article by Keeley J. Brookes et al published 19 June 2018 in Journal of Alzheimer's Disease

Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses.

scientific article

Glutamatergic systems in Alzheimer's disease.

scientific article published in September 2003

Imbalance of a serotonergic system in frontotemporal dementia: implication for pharmacotherapy

scientific article published on 18 November 2007

Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes

scientific article published in August 2000

Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease

scientific article published on 29 August 2005

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study

scientific article published on 27 January 2018

Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.

scientific article published on 28 November 2016

Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition.

scientific article

Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias

scientific article published on 08 September 2016

Inflammatory Mediators in the Frontal Lobe of Patients with Mixed and Vascular Dementia

scientific article published in 2008

Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease.

scientific article published on 5 July 2005

Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis

scientific article published on 30 March 2008

Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease

scientific article published on 18 November 2004

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration

scientific article published on 17 October 2018

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

scientific article

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.

scientific article published on 10 January 2012

Memantine potentiates hippocampal θ oscillations at a therapeutic dose in anesthetized mice: a mechanistic link to its cognitive-enhancing properties

scientific article

Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease

scientific article published on 12 December 2017

Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia.

scientific article published on 20 September 2016

NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones

scientific article published on November 20, 1992

NMDA‐induced glutamate and aspartate release from rat cortical pyramidal neurones: evidence for modulation by a 5‐HT1A antagonist ⬇️

scientific article published on August 1, 1995

Neurochemical basis for symptomatic treatment of Alzheimer's disease

scientific article published on 13 February 2010

Neurochemical changes in a double transgenic mouse model of Alzheimer's disease fed a pro-oxidant diet

scientific article published on 30 June 2010

Neuronal Degeneration by Suicide Transport Following Injection of Volkensin into Rat Cerebral Cortex ⬇️

scientific article published on September 1, 1997

Neuronal pathology in relation to molecular biology and treatment of Alzheimer’s disease ⬇️

scientific article published on January 1, 1994

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

scientific article

Neuropsychiatric Symptoms in Patients with Dementias Associated with Cortical Lewy Bodies: Pathophysiology, Clinical Features, and Pharmacological Management ⬇️

scientific article published on August 1, 2013

Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future

scientific article

Noradrenergic changes, aggressive behavior, and cognition in patients with dementia

scientific article published in March 2002

Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia

scientific article

Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease

article

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease

scientific article published on 7 May 2016

Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.

scientific article

Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

scientific article published in November 2008

Postmortem Cortical Transcriptomics of Lewy Body Dementia Reveal Mitochondrial Dysfunction and Lack of Neuroinflammation

scientific article published on 24 June 2019

Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease

scientific article published in July 2002

Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice.

scientific article published on 17 August 2010

Protease 'Clipsin' extract activity reflects demographic characteristics of human brain

scientific article published on August 31, 1992

Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture

article

Protection from dementia

scientific article published on November 27, 1992

Randomized controlled trial of mibampator for behavioral and psychological symptoms of dementia: comments on the trial and thoughts for future studies ⬇️

scientific article published on January 25, 2013

Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease

scientific article published in June 2003

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

scientific article

Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias

scientific article published on 30 October 2014

Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer's disease are not present in diabetic Alzheimer's disease

scientific article published on 06 August 2019

Selective Loss of Cholinergic Receptors Following Unilateral Intracortical Injection of Volkensin ⬇️

scientific article published on September 1, 1997

Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease

scientific article published on 9 February 2006

Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology

scientific article published on 28 May 2008

Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms

scientific article published on September 1, 1992

Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status.

scientific article published on May 2014

Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status

scientific article published on 3 December 2016

Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients

scientific article published in July 2003

Spreading pathologies precede cognitive decline in Alzheimer's disease.

scientific article published in April 2015

Stage-specific changes in neurogenic and glial markers in Alzheimer's disease

scientific article published on 9 June 2014

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

scientific article published on 9 January 2018

Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice

scientific article published on 05 November 2011

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.

scientific article published on 22 May 2016

Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease

scientific article published on 13 December 2010

Tacrine may alter APP-like protein levels in the lumbar CSF of Alzheimer patients

scientific article published on 01 November 2001

Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia.

scientific article published on 3 March 2012

Ticking boxes or meaningful partnership - The experience of lay representation, participant and study partner involvement in Brains for Dementia Research

scientific article published on 01 November 2018

Unfolded protein response is activated in Lewy body dementias.

scientific article published on 17 August 2015

Vesicular glutamate transporter and cognition in stroke: a case-control autopsy study.

scientific article

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.

scientific article published on 27 November 2017

[3H]GR113808 binding to serotonin 5-HT(4) receptors in the postmortem neocortex of Alzheimer disease: a clinicopathological study.

scientific article

d-Cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-d-aspartate receptor-ionophore complex in Alzheimer brain ⬇️

scientific article published on November 29, 1991

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