List of works - Minna Nyström

A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one

scientific article published on 01 September 2011

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

scientific article

Agenesis of the corpus callosum and gray matter heterotopia in three patients with constitutional mismatch repair deficiency syndrome.

scientific article

Assessing how reduced expression levels of the mismatch repair genes MLH1, MSH2, and MSH6 affect repair efficiency

scientific article

Assessment of the InSiGHT Interpretation Criteria for the Clinical Classification of 24 MLH1 and MSH2 Gene Variants.

scientific article

Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice

scientific article

Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations.

scientific article

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

scientific article published on 22 July 2015

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

scientific article published on 18 December 2018

Diet and epigenetics in colon cancer.

scientific article published on January 2009

Functional Significance and Clinical Phenotype of Nontruncating Mismatch Repair Variants of MLH1

scientific article published in August 2005

Functional characterization of MLH1 missense variants identified in Lynch syndrome patients.

scientific article published on 23 July 2012

Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients.

scientific article published on 21 August 2009

Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome.

scientific article

Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6.

scientific article published on 2 November 2016

Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome

scientific article

Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR).

scientific article

Mechanisms of pathogenicity in human MSH2 missense mutants.

scientific article published in November 2008

Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.

scientific article published on 11 June 2012

Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer.

scientific article published in May 2018

PMS2 expression decrease causes severe problems in mismatch repair

scientific article published on 18 April 2019

Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein

scientific article published on 22 August 2006

Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein

scientific article published on 01 August 2003

The first functional study of MLH3 mutations found in cancer patients

scientific article published on 01 September 2008

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.

scientific article published in August 2008

Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon.

scientific article published on 17 April 2017

Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity.

scientific article published on 11 October 2016

List of works by Minna Nyström

A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

Agenesis of the corpus callosum and gray matter heterotopia in three patients with constitutional mismatch repair deficiency syndrome.

Assessing how reduced expression levels of the mismatch repair genes MLH1, MSH2, and MSH6 affect repair efficiency

Assessment of the InSiGHT Interpretation Criteria for the Clinical Classification of 24 MLH1 and MSH2 Gene Variants.

Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice

Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations.

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Diet and epigenetics in colon cancer.

Functional Significance and Clinical Phenotype of Nontruncating Mismatch Repair Variants of MLH1

Functional characterization of MLH1 missense variants identified in Lynch syndrome patients.

Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients.

Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome.

Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6.

Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome

Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR).

Mechanisms of pathogenicity in human MSH2 missense mutants.

Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.

Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer.

PMS2 expression decrease causes severe problems in mismatch repair

Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein

Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein

The first functional study of MLH3 mutations found in cancer patients

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.

Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon.

Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity.