List of works - Dorian B McGavern

A little 'help' from IL-21 during persistent viral infection

scientific article

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

scientific article published on 08 September 2021

A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells

scientific article published on July 2008

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica

scientific article

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

scientific article published on November 2004

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

scientific article published on February 1998

Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus.

scientific article

Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection

scientific article

Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.

scientific article

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

scientific article published in December 2003

Antimicrobial immunity impedes CNS vascular repair following brain injury

scientific article published on 23 September 2021

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells

scientific article published on 11 February 2021

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection

scientific article published on 20 July 2018

Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.

scientific article

CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective

scientific article published on 10 March 2006

Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.

scientific article published on March 2002

Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification.

scientific article published on 6 June 2007

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

scientific article published in Science

Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging

scientific article

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury.

scientific article

Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest

scientific article

Gut-educated IgA plasma cells defend the meningeal venous sinuses

scientific article published on 04 November 2020

HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis

scientific article

IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection

scientific article published on 10 March 2008

Illuminating viral infections in the nervous system

scientific article

Immunotherapeutic relief from persistent infections and amyloid disorders.

scientific article

In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells

scientific article published on 10 February 2022

In vivo dynamics of innate immune sentinels in the CNS.

scientific article

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity

scientific article published on 18 March 2019

Inflammation and neuroprotection in traumatic brain injury

scientific article

Inflammation on the mind: visualizing immunity in the central nervous system.

scientific article published on January 2009

Interleukin-10 determines viral clearance or persistence in vivo

scientific article (publication date: November 2006)

Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.

scientific article

Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection

scientific article

MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis

scientific article

Microglia development and function

scientific article

Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection

scientific article

Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan.

scientific article published on 15 October 2001

Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes

scientific article

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

scientific article

Optimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED).

scientific article

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

scientific article published on 25 March 2013

Perforin-dependent neurologic injury in a viral model of multiple sclerosis.

scientific article published in September 1998

Primary demyelination in transgenic mice expressing interferon-gamma

scientific article published on September 1997

Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination.

scientific article

Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis

scientific article published on October 2000

Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells.

scientific article published on October 2004

Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection

scientific article

Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway

scientific article

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

scientific article published on 17 June 2019

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

scientific article published on 29 April 2015

T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection

scientific article published on 01 June 2020

T cells in the central nervous system: the delicate balance between viral clearance and disease

scientific article

Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody

scientific article published on 01 February 2005

Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury

scientific article published on 18 January 2021

The anatomy and immunology of vasculature in the central nervous system

scientific article published on 01 July 2019

Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection.

scientific article published on 24 June 2009

Transcranial amelioration of inflammation and cell death after brain injury.

scientific article

Two-photon imaging of microbial immunity in living tissues ⬇️

scientific article published on August 1, 2012

Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system

scientific article (publication date: 2013)

Viral diseases of the central nervous system

scholarly article by Phillip A Swanson published in April 2015

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells ⬇️

scientific article published on May 2, 2011

Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection.

scientific article published in May 2004

List of works by Dorian B McGavern

A little 'help' from IL-21 during persistent viral infection

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus.

Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection

Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

Antimicrobial immunity impedes CNS vascular repair following brain injury

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells

BST-2 controls T cell proliferation and exhaustion by shaping the early distribution of a persistent viral infection

Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.

CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective

Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.

Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification.

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury.

Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest

Gut-educated IgA plasma cells defend the meningeal venous sinuses

HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis

IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection

Illuminating viral infections in the nervous system

Immunotherapeutic relief from persistent infections and amyloid disorders.

In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells

In vivo dynamics of innate immune sentinels in the CNS.

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity

Inflammation and neuroprotection in traumatic brain injury

Inflammation on the mind: visualizing immunity in the central nervous system.

Interleukin-10 determines viral clearance or persistence in vivo

Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.

Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection

MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis

Microglia development and function

Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection

Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan.

Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

Optimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED).

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

Perforin-dependent neurologic injury in a viral model of multiple sclerosis.

Primary demyelination in transgenic mice expressing interferon-gamma

Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination.

Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis

Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells.

Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection

Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection

T cells in the central nervous system: the delicate balance between viral clearance and disease

Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody

Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury

The anatomy and immunology of vasculature in the central nervous system

Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection.

Transcranial amelioration of inflammation and cell death after brain injury.

Two-photon imaging of microbial immunity in living tissues ⬇️

Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system

Viral diseases of the central nervous system

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells ⬇️

Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection.