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List of works by Graham Rook

16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis

scientific article published on 9 December 2004

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: darwinian medicine and the 'hygiene' or 'old friends' hypothesis

scientific article published on 01 April 2010

A comparative analysis of disease-associated changes in the galactosylation of serum IgG

article

A longitudinal study of per cent agalactosyl IgG in tuberculosis patients receiving chemotherapy, with or without immunotherapy

scientific article published on 01 January 1994

A model for the investigation of factors influencing haemorrhagic necrosis mediated by tumour necrosis factor in tissue sites primed with mycobacterial antigen preparations

scientific article

A monoclonal antibody raised by immunising mice with group A streptococci binds to agalactosyl IgG from rheumatoid arthritis

scientific article published on March 1988

A reappraisal of the evidence that rheumatoid arthritis and several other idiopathic diseases are slow bacterial infections.

scientific article

A sensitive, non-radioactive quantitative method for measuring IL-4 and IL-4delta2 mRNA in unstimulated cells from multiple clinical samples, using nested RT-PCR.

scientific article

Adrenal function and the hypothalamo-pituitary adrenal axis in immunodeficiency virus-associated tuberculosis.

scientific article published in June 1997

Advances in immunotherapy for tuberculosis treatment

scientific article published on December 2009

Advances in the immunopathogenesis of pulmonary tuberculosis.

scientific article

Aetiology of tuberculids

scientific article published in The Lancet

Agalactosyl IgG and Antibody Specificity in Rheumatoid Arthritis, Tuberculosis, Systemic Lupus Erythematosus and Myasthenia Gravis

scientific article published on 01 January 1995

Agalactosyl IgG and materno-fetal transmission of autoimmune neonatal lupus

article

Agalactosyl IgG in inflammatory bowel disease: correlation with C-reactive protein.

scientific article

Agalactosyl IgG in pristane-induced arthritis. Pregnancy affects the incidence and severity of arthritis and the glycosylation status of IgG

scientific article published on September 1, 1992

Agalactosyl IgG is elevated in patients with active spondyloarthropathy

scientific article published on 01 January 1999

An association between Gc (vitamin D-binding protein) alleles and susceptibility to rheumatic fever.

scientific article

An inhibitor of the toxicity of tumour necrosis factor in the serum of patients with sarcoidosis, tuberculosis and Crohn's disease ⬇️

scientific article published on June 1, 1990

An investigation of patients with pulmonary tuberculosis in Kuwait in preparation for studies of immunotherapy with Mycobacterium vaccae.

scientific article

Analysis of glycosylation changes in IgG using lectins

article

Antibodies to Heat Shock Protein 65 kD in Type 1 Diabetes Mellitus

scientific article published on 01 January 1994

Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. bovis in rheumatoid arthritis

article

Antilymphocyte Serum and Tissue Culture Used to Investigate Role of Cell-mediated Response in Viral Encephalitis in Mice ⬇️

scientific article published on October 24, 1970

Attachment of mycobacteria to fibronectin-coated surfaces

scientific article published on 01 May 1988

Autoimmune reactions to heat-shock proteins in pristane-induced arthritis.

scientific article

CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts.

scientific article published on 19 January 2011

Can nerve damage disrupt neuroendocrine immune homeostasis? Leprosy as a case in point.

scientific article

Can we vaccinate against depression?

scientific article published on 07 April 2012

Cat allergen and sensitization

scientific article published in The Lancet

Changes in IgG glycoform levels are associated with remission of arthritis during pregnancy

scientific article published on 01 October 1991

Changes in cellular response to mycobacterial antigens and cytokine production patterns in leprosy patients during multiple drug therapy

article

Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG

scientific article

Chemoprophylaxis for tuberculosis

scientific article published on 01 July 1993

Childhood microbial experience, immunoregulation, inflammation and adult susceptibility to psychosocial stressors and depression in rich and poor countries

scientific article

Clean living increases more than just atopic disease

scientific article published on 01 May 2000

Comment on the article by Tomana et al

scientific article published on 01 February 1989

Comments on the new analysis of the Chingleput BCG trial

scientific article published on 01 February 2006

Cortisol metabolism, cortisol sensitivity and the pathogenesis of leprosy reactions.

scientific article

Crohn's disease and MAP.

scientific article

Cytokine analysis at the single cell level and lymphoproliferative responses to mycobacterial antigens in HIV-1 patients with successful virologic response to potent antiretrovirals

scientific article published on 01 November 2000

Cytokines, lymphokines, mycobacteria and AIDS

scientific article published on May 1, 1992

DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway

scientific article (publication date: April 2011)

Dangers of therapeutic manipulation of the Th1–Th2 balance

scientific article published on 01 March 2002

Development of IgG responses to mycobacterial antigens.

scientific article

Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

scientific article

Does antibody to mycobacterial antigens, including lipoarabinomannan, limit dissemination in childhood tuberculosis?

scientific article published on November 1, 1992

Effect of sample handling on analysis of cytokine responses to Mycobacterium tuberculosis in clinical samples using ELISA, ELISPOT and quantitative PCR.

scientific article published in March 2005

Elevated IgG Antibody Levels to the Mycobacterial 65-kDa Heat Shock Protein Are Characteristic of Patients with Rheumatoid Arthritis

scientific article published on 01 November 1989

Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis.

scientific article published in November 1998

Endocrine and cytokine responses in humans with pulmonary tuberculosis

scientific article published on 20 September 2006

Erasures from the “Register”.

scientific article

Ex vivo cytokine mRNA levels correlate with changing clinical status of ethiopian TB patients and their contacts over time

scientific article

Expression of IL-4 mRNA in peripheral blood mononuclear cells from normal donors in relation to expression of TLR2

Expression of a novel cytokine, IL-4delta2, in HIV and HIV-tuberculosis co-infection.

scientific article

Expression of apoptosis-related genes in an Ethiopian cohort study correlates with tuberculosis clinical status

scientific article published in January 2010

Extrapulmonary locations of mycobacterium tuberculosis DNA during latent infection.

scientific article

FOXP3 gene expression in a tuberculosis case contact study.

scientific article

Focus: Tuberculosis

article

GALACTOSYLATION OF IgG ASSOCIATED OLIGOSACCHARIDES

scientific article published in The Lancet

Galactosylation of human IgG monoclonal anti-D produced by EBV-transformed B-lymphoblastoid cell lines is dependent on culture method and affects Fc receptor-mediated functional activity.

scientific article published on January 1994

Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosis

article

Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins ⬇️

scientific article published on August 1, 1991

Give us this day our daily germs

scientific article published on 01 August 2002

Glycosylation of lgG during potentially arthritogenic lentiviral infections

scientific article published on 01 January 1995

Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile? ⬇️

scientific article published on June 21, 1997

HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state

article

HLA-DR-associated isotype-specific regulation of antibody levels to mycobacteria in rheumatoid arthritis

scientific article published in April 1988

HLA-DR4, mycobacteria, heat-shock proteins, and rheumatoid arthritis

scientific article published on 01 December 1992

Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2.

scientific article published in June 2004

Higher tuberculosis mortality in India seen in those who have ever smoked.

scientific article published in February 2004

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance.

scientific article published on July 1994

Hygiene Hypothesis and Autoimmune Diseases ⬇️

scientific article published on February 1, 2012

Hygiene and Other Early Childhood Influences on the Subsequent Function of the Immune System ⬇️

scientific article published on 05 July 2011

Hygiene and other early childhood influences on the subsequent function of the immune system.

scientific article

INCREASED LEVELS OF PROLACTIN DURING, BUT NOT AFTER, THE IMMUNISATION WITH RAT COLLAGEN II ENHANCES THE COURSE OF ARTHRITIS IN DBA/1 MICE

scientific article published on 01 January 1992

Identification of an antigenic domain on Mycobacterium leprae protein antigen 85B, which is specifically recognized by antibodies from patients with leprosy

scientific article published in January 1994

IgG glycosylation in autoimmune-prone strains of mice

scientific article published on 01 January 1994

Il-4 influences apoptosis of mycobacterium-reactive lymphocytes in the presence of TNF-alpha.

scientific article published in August 2001

Immunoendocrinological hypothesis of HIV infection

scientific article published in The Lancet

Immunological and endocrinological characteristics of tuberculosis that provide opportunities for immunotherapeutic intervention

scientific article published on 01 January 1998

Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis

article

Immunotherapeutics for tuberculosis in experimental animals: is there a common pathway activated by effective protocols?

scientific article published on 5 June 2007

Immunotherapy with Mycobacterium vaccae as an addition to chemotherapy for the treatment of pulmonary tuberculosis under difficult conditions in Africa.

scientific article

Immunotherapy with Mycobacterium vaccae as an adjunct to chemotherapy in the treatment of pulmonary tuberculosis

scientific article published on 01 June 1990

Immunotherapy with mycobacteria ⬇️

scientific article published on December 1, 2003

Increased Cortisol

article

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

scientific article

Induction of delayed-type hypersensitivity responses to PPD: dendritic cells in synergy with 5-hydroxytryptamine can substitute for macrophages ⬇️

scientific article published on April 1, 1988

Infection, immunoregulation, and cancer.

scientific article

Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression.

scientific article published on December 2010

Inflammatory bowel disease

scientific article published in The Lancet

Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae

scientific article published in March 1998

Innate immune responses to mycobacteria and the downregulation of atopic responses.

scientific article published on October 2003

Interferon gamma assays for tuberculosis

scientific article published on 01 June 2005

Interleukin-4 and Its Alternatively Spliced Variant (IL-4 δ 2) in Patients with Atopic Asthma

scientific article published on 01 September 2001

Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results

scientific article published on 19 April 2007

Intractable mycobacterial infections associated with genetic defects in the receptor for interferon gamma: what does this tell us about immunity to mycobacteria? ⬇️

scientific article published on August 1, 1997

Intragastric administration of Mycobacterium vaccae inhibits severe pulmonary allergic inflammation in a mouse model

scientific article

Is the Gulf War syndrome an immunologically mediated phenomenon?

scientific article published on 01 January 1998

Is the adherent, non-specific 'suppressor' cell from rodent spleens an in vitro artefact? ⬇️

scientific article published on June 1, 1978

Is the macrophage the site of the immunosuppressive action of rifampicin?

scientific article published in December 1973

Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomized, double-blind, placebo-controlled trial

scientific article published on 01 September 2006

Local regulation of glucocorticoid activity in sites of inflammation. Insights from the study of tuberculosis.

scientific article

Long-Term Protective and Antigen-Specific Effect of Heat-Killed Mycobacterium vaccae in a Murine Model of Allergic Pulmonary Inflammation

article

Lymphocytes in neuroprotection, cognition and emotion: is intolerance really the answer?

scientific article published on 16 December 2010

Mechanisms of disease: the hygiene hypothesis revisited.

scientific article

Microbes, immunoregulation, and the gut.

scientific article

Microbial 'Old Friends', immunoregulation and stress resilience.

scientific article published on January 2013

Microbial 'old friends', immunoregulation and socioeconomic status.

scientific article

Mobilising the appropriate T-cell subset: the immune response as taxonomist? ⬇️

scientific article published on December 1, 1991

Modelling gene-environment interactions in Th1- and Th2-dominated diseases of laboratory animals.

scientific article

Modulation of cell death by M. tuberculosis as a strategy for pathogen survival

scientific article published on 04 January 2011

Modulation of pristane-induced arthritis by mycobacterial antigens

scientific article published in January 1991

Mycobacteria and allergies.

scientific article published on 17 April 2007

Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders.

scientific article

Mycobacteria and rheumatoid arthritis

article

Mycobacteria and sarcoidosis: Authors' reply.

scientific article published in May 1993

Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice

scientific article published in March 2004

Mycobacterium vaccae: a study of safety and outcome measures

scientific article published on 01 March 1998

Neonatal Myasthenia Gravis and the Role of Agalactosyl IgG

scientific article published on 01 January 1995

New meanings for an old word: adjuvanticity, cytokines and T cells.

scientific article published in February 1993

Old friends for breakfast

scientific article published on 01 July 2005

Old plague, new plague, and a treatment for both?

scientific article published on 01 September 1993

Oral treatment with SRP299 (killed Mycobacterium vaccae) inhibits experimental periodontal disease in Wistar rats

scientific article published in November 2003

Orally administered Mycobacterium vaccae modulates expression of immunoregulatory molecules in BALB/c mice with pulmonary tuberculosis

scientific article published on 30 September 2008

Pathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte before infection ⬇️

scientific article published on August 1, 1997

Pathogenetic role, in human and murine tuberculosis, of changes in the peripheral metabolism of glucocorticoids and antiglucocorticoids

scientific article published on 01 January 1997

Pathways underlying afferent signaling of bronchopulmonary immune activation to the central nervous system.

scientific article published on 26 June 2012

Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count

article

Peripheral T cell interferon-gamma responses and latent tuberculosis

scientific article published in July 2004

Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection

scientific article published in The Lancet

Phage display of functional αβ single-chain T-cell receptor molecules specific for CD1b:Ac₂SGL complexes from Mycobacterium tuberculosis-infected cells

scientific article

Possible improved survival of patients with stage IV AJCC melanoma receiving SRL 172 immunotherapy: Correlation with induction of increased levels of intracellular interkukin-2 in peripheral blood lymphocytes

scientific article published on 01 July 1999

Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients

scientific article published in October 1976

Preliminary taxonomic studies on the leprosy bacillus ⬇️

scientific article published on December 1, 1975

Presence of hsp65 in bacterial extracts (OM-89): a possible mediator of orally-induced tolerance?

scientific article published on August 1995

Prevention of Experimental Myointimal Hyperplasia by Immunomodulation

scientific article published on 01 January 2002

Production of tumor necrosis factor-alpha by blood and lung mononuclear phagocytes from patients with human immunodeficiency virus-related lung disease

scientific article published in August 1991

Progress and hindrances in tuberculosis vaccine development

scientific article published in The Lancet

Pulmonary bovine-type tuberculosis in rabbits: bacillary virulence, inhaled dose effects, tuberculin sensitivity, and Mycobacterium vaccae immunotherapy.

scientific article

Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis

scientific article published in January 2004

RELATIONSHIP BETWEEN INTERLEUKIN 6, AGALACTOSYL IgG AND PRISTANE-INDUCED ARTHRITIS

scientific article published on 01 January 1992

Raised agalactosyl IgG and antimycobacterial humoral immunity in Takayasu's arteritis

scientific article published on 01 October 1994

Raised levels of agalactosyl IgG in childhood tuberculosis

scientific article published on 01 March 1996

Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.

scientific article

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis

scientific article

Regulation of inflammation by interleukin-4: a review of “alternatives” ⬇️

scientific article published on July 10, 2012

Regulation of the immune system by biodiversity from the natural environment: an ecosystem service essential to health

scientific article

Rheumatoid arthritis: how well do the theories fit the evidence?

scientific article published in 1993

Role of activated macrophages in the immunopathology of tuberculosis.

scientific article published on July 1988

Search for mycobacterial DNA in granulomatous tissues from patients with sarcoidosis using the polymerase chain reaction

scientific article published on 01 March 1993

Selective expression of V beta families by T cells in the blood and salivary gland infiltrate of patients with primary Sjögren's syndrome

scientific article published on 01 October 1994

Skin-test responses to mycobacteria in atopy and asthma

article

Smoking is not beneficial for tuberculosis

scientific article published in October 2004

Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn's disease.

scientific article

Specificity of primers based on IS6110 to Mycobacterium tuberculosis complex DNA

scientific article published on 01 December 1993

Steroid Metabolism and Immunity

article

Stop TB: a long way to go, but new twists & turns in the science

scientific article published on 01 February 2007

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

scientific article published on 01 June 2002

TH1/TH2 switching and loss of CD4+ T cells in chronic infections: an immunoendocrinological hypothesis not exclusive to HIV

article

TNFα-mediated tissue damage in mouse footpads primed with mycobacterial preparations

scientific article published on 01 July 1992

Taxonomic studies on the leprosy bacillus

scientific article published on 01 January 1976

Terminal N-acetylglucosamine in chronic synovitis

scientific article published on 01 February 1990

Th1- or Th2-cell commitment during infectious disease: an oversimplification?

scientific article published in September 2001

Th2 cytokines in susceptibility to tuberculosis.

scientific article published on May 2007

The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon

scientific article

The Koch phenomenon and the immunopathology of tuberculosis.

scientific article published on January 1996

The Role of Vitamin D in Tuberculosis

scientific article published on 01 October 1988

The TGF-β1 paradox in asthma

scientific article published on 01 June 2001

The changing microbial environment and chronic inflammatory disorders.

scientific article

The development of monoclonal antibodies to the human mitochondrial 60-kd heat-shock protein, and their use in studying the expression of the protein in rheumatoid arthritis

scientific article

The dissociation of adjuvant properties of mycobacterial components from mitogenicity, and from the ability to induce the release of mediators from macrophages

scientific article published on 01 September 1976

The effect of Mycobacterium tuberculosis on the susceptibility of human cells to the stimulatory and toxic effects of tumour necrosis factor.

scientific article published on December 1992

The effect of lymph-node cells from specifically sensitised mice, on the growth of the BP8 ascites tumor "in vivo" and "in vitro".

scientific article

The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma

scientific article published in February 2003

The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice

article

The hygiene hypothesis and psychiatric disorders

scientific article published on 6 March 2008

The immunological consequences of antigen overload in experimental mycobacterial infections of mice ⬇️

scientific article published on January 1, 1975

The importance of models of infection in the study of disease resistance.

scientific article

The interaction of Tamm-Horsfall protein with the extracellular matrix

scientific article published on 01 June 1993

The molecular mechanisms of severe typhoid fever.

scientific article published on July 2001

The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products ⬇️

scientific article published on July 1, 1975

The protective effect of immunoglobulin in murine tuberculosis is dependent on IgG glycosylation.

scientific article

The relevance to protection of three forms of delayed skin-test response evoked by M. leprae and other mycobacteria in mice. Correlation with the classical work in the guinea-pig ⬇️

scientific article published on January 1, 1979

The role of IgG glycoforms in the pathogenesis of rheumatoid arthritis

scientific article published on January 1988

The role of TNF-alpha in T-cell-mediated inflammation depends on the Th1/Th2 cytokine balance

scientific article published on 01 August 1994

The role of activated macrophages in protection and immunopathology in tuberculosis

scientific article published in February 1990

The role of cytokines in the immunopathology of tuberculosis, and the regulation of agalactosyl IgG.

scientific article

The role of oil and agalactosyl IgG in the induction of arthritis in rodent models

scientific article published on 01 April 1991

The secreted antigens of Mycobacterium tuberculosis and their relationship to those recognized by the available antibodies

scientific article published on 01 February 1988

The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not

scholarly article by Keertan Dheda et al published May 2007 in Tuberculosis

The use of antigen-bearing nitrocellulose particles derived from Western blots to study proliferative responses to 27 antigenic fractions from Mycobacterium leprae in patients and controls

article

Three forms of delayed skin-test response evoked by mycobacteria ⬇️

scientific article published on January 5, 1978

Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice

scientific article published in June 2000

Treatment with SRL172 (heat-killed Mycobacterium vaccae) inhibits progression of established experimental periodontal disease in Wistar rats

scientific article published on 01 June 2002

Tuberculosis and HIV: light after darkness.

scientific article published on June 1994

Tuberculosis and cancer: parallels in host responses and therapeutic approaches?

scientific article published on May 1995

Tuberculosis due to high-dose challenge in partially immune individuals: a problem for vaccination?

scientific article published in March 2009

Tuberculosis in children

scientific article published on 01 February 1995

Tumour necrosis factor production by alveolar macrophages in pulmonary sarcoidosis and tuberculosis

scientific article published on March 1, 1992

Tumours and Coley's toxins

scientific article

Type 2 Cytokine Gene Activation and Its Relationship to Extent of Disease in Patients with Tuberculosis

article

Vaccination and skin test studies on children living in villages with differing endemicity for leprosy and tuberculosis

scientific article published on 01 March 1989

Validation of housekeeping genes for normalizing RNA expression in real-time PCR.

scientific article

Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar

scientific article

Variation within Mycobacterium scrofulaceum

scientific article published on 01 November 1997

[ON THE ANTIBODY RESPONSE TO ANTIPOLIOMYELITIC VACCINE (SABIN TYPE) IN A GROUP OF CHILDREN OF THE PROVINCE OF PISA.]

scientific article published on 01 September 1964

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