List of works - Nicole Kleinstreuer

3S - Systematic, systemic, and systems biology and toxicology

scientific article published in January 2018

A C. elegans screening platform for the rapid assessment of chemical disruption of germline function

scientific article

A Curated Database of Rodent Uterotrophic Bioactivity.

scientific article published on 2 October 2015

A Vision of Toxicity Testing in the 21st Century

article

A computational model predicting disruption of blood vessel development

scientific article

A design thinking approach to primary ovarian insufficiency

scientific article published on 9 November 2016

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

scientific article published on 18 January 2011

Adverse outcome pathways: From research to regulation scientific workshop report

scientific article published on 14 January 2016

An Integrated Chemical Environment to Support 21st-Century Toxicology

scientific article published on 24 May 2017

An evaluation framework for new approach methodologies (NAMs) for human health safety assessment

scientific article published on 01 February 2020

An integrated chemical environment with tools for chemical safety testing

scientific article published on 14 June 2020

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

scientific article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Bringing Big Data to Bear in Environmental Public Health: Challenges and Recommendations

scientific article published on 15 May 2020

Chronic inflammation in the etiology of disease across the life span

scientific article published on 05 December 2019

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

scientific article published on 07 February 2020

Computational Toxicology

scientific article published on 01 March 2020

Correction to Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

scientific article

Development and Validation of a Computational Model for Androgen Receptor Activity

scientific article

Development of a curated Hershberger database

article

Disruption of embryonic vascular development in predictive toxicology

scientific article published on December 2011

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

scientific article published on 17 September 2013

Dynamic myogenic autoregulation in the rat kidney: a whole-organ model.

scientific article published on 19 March 2008

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences.

scientific article published on 17 May 2017

Embryonic vascular disruption adverse outcomes: Linking high-throughput signaling signatures with functional consequences

scientific article published on 13 April 2017

Environmental impact on vascular development predicted by high-throughput screening

scientific article

Evaluation and Optimization of Pharmacokinetic Models for in Vitro to in Vivo Extrapolation of Estrogenic Activity for Environmental Chemicals.

scientific article published in September 2018

Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay

scientific article

Evaluation of androgen assay results using a curated Hershberger database

scientific article published on 08 September 2018

Exploring current read-across applications and needs among selected U.S. Federal Agencies

scientific article published on 10 May 2019

Exploring drug space with ChemMaps.com

scientific article published on 01 November 2018

Hierarchical Quantitative Structure-Activity Relationship Modeling Approach for Integrating Binary, Multiclass, and Regression Models of Acute Oral Systemic Toxicity

scientific article published on 05 February 2020

High-Throughput Screening to Identify Chemical Cardiotoxic Potential

scientific article published on 21 December 2020

High-Throughput Screening to Predict Chemical-Assay Interference

scientific article published on 04 March 2020

Highlight report: 'Big data in the 3R's: outlook and recommendations', a roundtable summary.

scientific article

Identification and Profiling of Environmental Chemicals That Inhibit the TGFβ/SMAD Signaling Pathway

scientific article published on 11 November 2019

Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium

scientific article published in November 2018

Identification of potential endocrine disrupting chemicals using gene expression biomarkers

scientific article published on 17 July 2019

Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells.

scientific article published on 9 November 2016

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics.

scientific article

Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform

scientific article

Immediate and long-term consequences of vascular toxicity during zebrafish development.

scientific article published on 4 June 2014

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

scientific article published on 22 December 2016

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

scientific article

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

scientific article published in December 2017

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

article

Integrated Testing Strategies (ITS) for safety assessment.

scientific article published on 19 November 2014

Integrated decision strategies for skin sensitization hazard

scientific article

Integrated decision strategies for skin sensitization hazard

scientific article published on 29 November 2017

Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

scientific article published on 04 May 2016

InterPred: a webtool to predict chemical autofluorescence and luminescence interference

scientific article published on 18 May 2020

International regulatory requirements for skin sensitization testing

scientific article published on 5 March 2018

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

scientific article published on 30 April 2020

Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations

scientific article

Mathematical modeling of renal autoregulation ⬇️

2009 doctoral thesis by Nicole Churchill Kleinstreuer at University of Canterbury

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

scientific article published on 13 November 2018

Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing

scientific article published on 01 July 2019

Multivariate Models for Prediction of Human Skin Sensitization Hazard

scientific article (publication date: 2 August 2016)

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database

scientific article published on 23 February 2018

Non-animal methods to predict skin sensitization (II): an assessment of defined approaches *.

scientific article published on 23 February 2018

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

scientific article

Open-source QSAR models for pKa prediction using multiple machine learning approaches

scholarly article

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

scientific article

Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals.

scientific article published on May 2017

Pred-Skin: A web portal for accurate prediction of human skin sensitizers

scientific article published on 16 July 2020

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

scientific article

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

scientific article published on 3 January 2015

Prediction of skin sensitization potency using machine learning approaches

scientific article published on 10 January 2017

Predictive Models for Acute Oral Systemic Toxicity: A Workshop to Bridge the Gap from Research to Regulation

article

Predictive modeling and computational toxicology

Predictive models and computational toxicology

scientific article

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

scientific article

QSAR models of human data can enrich or replace LLNA testing for human skin sensitization

scientific article

Regulatory acceptance of read-across

scientific article published on 01 January 2018

SAR and QSAR modeling of a large collection of LD rat acute oral toxicity data

scientific article published on 30 August 2019

Saagar-A New, Extensible Set of Molecular Substructures for QSAR/QSPR and Read-Across Predictions

scientific article published on 25 December 2020

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

scientific article

Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.

scientific article published on 19 December 2016

Selecting a minimal set of androgen receptor assays for screening chemicals

scientific article published on 13 August 2020

Skin sensitization testing needs and data uses by US regulatory and research agencies

journal article published in 2019

Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods

scientific article

Status of acute toxicity testing requirements and data uses by U.S. regulatory agencies

scientific article

Supporting read-across using biological data

scientific article (publication date: 2016)

Systems Modeling of Developmental Vascular Toxicity

scientific article published on 01 June 2019

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them

scientific article published on 09 March 2020

Toward Good Read-Across Practice (GRAP) guidance

scientific article

Tox21BodyMap: a webtool to map chemical effects on the human body

scientific article published on 03 June 2020

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

scientific article published on 21 February 2020

Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity

scientific article published on 06 July 2019

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

scientific article published on 15 May 2012

Workflow for defining reference chemicals for assessing performance of in vitro assays

scientific article published on 17 December 2018

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution

scientific article published on 01 April 2019

Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

scientific article

List of works by Nicole Kleinstreuer

3S - Systematic, systemic, and systems biology and toxicology

A C. elegans screening platform for the rapid assessment of chemical disruption of germline function

A Curated Database of Rodent Uterotrophic Bioactivity.

A Vision of Toxicity Testing in the 21st Century

A computational model predicting disruption of blood vessel development

A design thinking approach to primary ovarian insufficiency

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

Adverse outcome pathways: From research to regulation scientific workshop report

An Integrated Chemical Environment to Support 21st-Century Toxicology

An evaluation framework for new approach methodologies (NAMs) for human health safety assessment

An integrated chemical environment with tools for chemical safety testing

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Bringing Big Data to Bear in Environmental Public Health: Challenges and Recommendations

Chronic inflammation in the etiology of disease across the life span

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Computational Toxicology

Correction to Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

Development and Validation of a Computational Model for Androgen Receptor Activity

Development of a curated Hershberger database

Disruption of embryonic vascular development in predictive toxicology

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

Dynamic myogenic autoregulation in the rat kidney: a whole-organ model.

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences.

Embryonic vascular disruption adverse outcomes: Linking high-throughput signaling signatures with functional consequences

Environmental impact on vascular development predicted by high-throughput screening

Evaluation and Optimization of Pharmacokinetic Models for in Vitro to in Vivo Extrapolation of Estrogenic Activity for Environmental Chemicals.

Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay

Evaluation of androgen assay results using a curated Hershberger database

Exploring current read-across applications and needs among selected U.S. Federal Agencies

Exploring drug space with ChemMaps.com

Hierarchical Quantitative Structure-Activity Relationship Modeling Approach for Integrating Binary, Multiclass, and Regression Models of Acute Oral Systemic Toxicity

High-Throughput Screening to Identify Chemical Cardiotoxic Potential

High-Throughput Screening to Predict Chemical-Assay Interference

Highlight report: 'Big data in the 3R's: outlook and recommendations', a roundtable summary.

Identification and Profiling of Environmental Chemicals That Inhibit the TGFβ/SMAD Signaling Pathway

Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium

Identification of potential endocrine disrupting chemicals using gene expression biomarkers

Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells.

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics.

Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform

Immediate and long-term consequences of vascular toxicity during zebrafish development.

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

Integrated Testing Strategies (ITS) for safety assessment.

Integrated decision strategies for skin sensitization hazard

Integrated decision strategies for skin sensitization hazard

Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

InterPred: a webtool to predict chemical autofluorescence and luminescence interference

International regulatory requirements for skin sensitization testing

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations

Mathematical modeling of renal autoregulation ⬇️

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing

Multivariate Models for Prediction of Human Skin Sensitization Hazard

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database

Non-animal methods to predict skin sensitization (II): an assessment of defined approaches *.

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

Open-source QSAR models for pKa prediction using multiple machine learning approaches

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals.

Pred-Skin: A web portal for accurate prediction of human skin sensitizers

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

Prediction of skin sensitization potency using machine learning approaches

Predictive Models for Acute Oral Systemic Toxicity: A Workshop to Bridge the Gap from Research to Regulation

Predictive modeling and computational toxicology

Predictive models and computational toxicology

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

QSAR models of human data can enrich or replace LLNA testing for human skin sensitization

Regulatory acceptance of read-across

SAR and QSAR modeling of a large collection of LD rat acute oral toxicity data

Saagar-A New, Extensible Set of Molecular Substructures for QSAR/QSPR and Read-Across Predictions

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model