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List of works by Heather G Jørgensen

A comparison of normal and leukemic stem cell biology in Chronic Myeloid Leukemia.

scientific article

Alpha1-acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571.

scientific article published in January 2002

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

scientific article published on 16 September 2013

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia

scientific article

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.

scientific article published on 8 September 2009

Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.

scientific article

Characterization of cancer stem cells in chronic myeloid leukaemia.

scientific article

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

scientific article published on 11 September 2018

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

scientific article

Drug- not carrier-dependent haematological and biochemical changes in a repeated dose study of cyclosporine encapsulated polyester nano- and micro-particles: size does not matter.

scientific article published on 28 January 2015

Enhanced CML stem cell elimination in vitro by bryostatin priming with imatinib mesylate

scientific article published on October 2005

Evolving molecular therapy for chronic myeloid leukaemia--are we on target?

scientific article

Granulocyte--colony-stimulating factor (Filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase myelogenous leukemia

scientific article published in January 2005

Human neutrophil elastase is not a target for therapy in chronic myeloid leukaemia

scientific article published on 28 September 2006

Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.

scientific article published on September 2007

Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib.

scientific article published on 25 April 2009

Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate

scientific article published in January 2006

Investigation into omacetaxine solution stability for in vitro study

scientific article

Is there a cloud in the silver lining for imatinib?

scientific article

Isolation and therapeutic potential of human haemopoietic stem cells

scientific article published on March 2003

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.

scientific article

Modulation of sialyl Lewis X dependent binding to E-selectin by glycoforms of alpha-1-acid glycoprotein expressed in rheumatoid arthritis

scientific article

Neutralisation of TGF beta or binding of VLA-4 to fibronectin prevents rat tendon adhesion following transection

scientific article published in May 2005

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.

scientific article

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

scientific article published on 09 January 2007

Nuclear entrapment of BCR-ABL by combining imatinib mesylate with leptomycin B does not eliminate CD34+ chronic myeloid leukaemia cells.

scientific article published on 8 January 2009

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells

scientific article published on 05 April 2011

Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells

scientific article published on 9 January 2009

Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3

scientific article published on 01 February 2001

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

scientific article published in January 2002

Punish the parent not the progeny.

scientific article

Stage-specific alterations in serum levels of G-CSF in chronic myeloid leukaemia

scientific article published on 01 July 2003

Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models

scientific article published on 03 March 2014

Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence

scientific article published on 11 September 2020

Tyrosine Kinase Inhibitor Independent Gene Expression Signature in CML Offers New Targets for LSPC Eradication Therapy

scientific article published on 26 October 2022

Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy

Uptake of synthetic Low Density Lipoprotein by leukemic stem cells--a potential stem cell targeted drug delivery strategy

scientific article published on 22 September 2010

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