List of works - Mercedes Martín-Martínez

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

scientific article published on 02 April 2010

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan Domain

scientific article published on 01 November 1999

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.

scientific article published in June 2001

An iterative structure-assisted approach to sequence alignment and comparative modeling

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

scientific article published in May 2005

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

scientific article published on 22 October 2012

Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction

scientific article published on 25 January 2008

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

scientific article published in July 2005

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

scientific article

Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.

scientific article

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.

scientific article

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

scientific article

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

article

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

scientific article published on 01 May 2015

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

scientific article published in January 2002

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

scientific article published on 24 March 2007

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis

scientific article published on 17 December 2014

Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.

scientific article

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

scientific article published on 4 February 2013

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

scientific article published in January 1999

Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.

scientific article published on 21 October 2016

Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.

scientific article published on 4 January 2017

Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements

scientific article

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

scientific article

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

scientific article published on 18 July 2011

Strategies for design of non peptide CCK1R agonist/antagonist ligands.

scientific article

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

scientific article published in October 1997

Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.

scientific article published in November 2004

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

scientific article published on 2 May 2006

beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.

scientific article published in October 2000

List of works by Mercedes Martín-Martínez

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan Domain

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.

An iterative structure-assisted approach to sequence alignment and comparative modeling

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis

Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.

Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.

Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

Strategies for design of non peptide CCK1R agonist/antagonist ligands.

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.