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List of works by Britta Engelhardt

A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis

scientific article published on 11 April 2017

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

scientific article published in September 2005

A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow

scientific article published on 19 December 2018

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

scientific article (publication date: 2014)

A transmembrane tight junction protein selectively expressed on endothelial cells and platelets

scientific article (publication date: 3 May 2002)

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier

scientific article published in January 2016

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Adhesion and Signalling Molecules Controlling the Extravasation of Leukocytes across the Endothelium ⬇️

scientific article published on March 27, 2008

Adhesion molecule phenotype of T lymphocytes in inflamed CNS.

scientific article published in April 1998

Advancing brain barriers RNA sequencing: guidelines from experimental design to publication

scientific article published on 18 August 2020

Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions

scientific article published on 30 October 2020

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis

scientific article

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

scientific article published on 01 April 2020

Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts

scientific article published on 13 November 2003

Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

scientific article

Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective

scientific article published on 26 November 2020

Brain barriers in health and disease

scientific article published on 24 May 2017

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

scientific article

Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro.

scientific article published on 24 August 2007

Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.

scientific article published in March 2011

Building up the blood-brain barrier

scientific article published in July 2003

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.

scientific article

CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin

scientific article published on 29 May 2020

CD45RA+ ICAM-3+ lymphocytes in interferon-beta1b-treated and -untreated patients with relapsing-remitting multiple sclerosis

scientific article published on 01 December 2004

CD45RA+ ICAM-3+ lymphocytesin cerebrospinal fluid and blood as markers of disease activity in patients with multiple sclerosis

scientific article published on 01 November 2000

CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation

scientific article published on 26 July 2019

Capture, crawl, cross: the T cell code to breach the blood–brain barriers ⬇️

scientific article published on August 25, 2012

Caveolin-1 opens endothelial cell junctions by targeting catenins.

scientific article published on 29 September 2011

Cell adhesion molecules on vessels during inflammation in the mouse central nervous system

scientific article published in May 1994

Cell surface bound and soluble adhesion molecules in CSF and blood in multiple sclerosis: correlation with MRI-measures of subclinical disease severity and activity

scientific article published on 01 January 2002

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

scientific article published on 23 January 2015

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

scientific journal article

Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse

scientific article published in July 2001

Claudin-12 is not required for blood-brain barrier tight junction function

scientific article published on 12 September 2019

Claudin-3-deficient C57BL/6J mice display intact brain barriers

scientific article published in Scientific Reports

Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation

scientific article

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing

scientific article

Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

scientific article published on 28 July 2020

Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo

scientific article

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

scientific article

Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis

scientific article published in May 2009

DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation

scientific article published on 12 March 2014

Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice

scientific article published on 23 January 2015

Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium

scientific article published on 22 September 2010

Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles

scientific article published in March 2003

Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node

article

Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.

scientific article published on 09 January 2017

Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis.

scientific article published in September 2006

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice

scientific article published on 01 December 2007

Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis

scientific article published on 20 April 2008

Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo

scientific article published in December 2002

Endogenous estrogens, through estrogen receptor α, constrain autoimmune inflammation in female mice by limiting CD4+ T-cell homing into the CNS.

scientific article published on 11 November 2010

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.

scientific article published on 10 February 2009

Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines.

scientific article

Estrogen receptor α signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis.

scientific article published in August 2011

Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod

scientific article

Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle

scientific article

Foreword

scientific article published on 01 January 2001

Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephal

scientific article published in August 2002

Functions of lipid raft membrane microdomains at the blood-brain barrier

scientific article published on 30 May 2009

Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-alpha

scientific article published in July 2003

Glycosylation processing inhibition by castanospermine prevents experimental autoimmune encephalomyelitis by interference with IL-2 receptor signal transduction

scientific article published in November 2002

Going Against the Tide – How Encephalitogenic T Cells Breach the Blood-Brain Barrier ⬇️

scientific article published on August 29, 2012

Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

scientific article published on 03 February 2020

IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

scientific article

Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines.

scientific article published on 24 June 2008

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

scientific article

Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation

scientific article published on 20 March 2020

Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro ⬇️

scientific article published on May 1, 1990

Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody.

scientific article published on July 1998

Immunologic privilege in the central nervous system and the blood-brain barrier

scientific article published on 17 October 2012

Immunotherapy of experimental autoimmune encephalomyelitis (EAE): Differential effect of anti-IL-2 receptor antibody therapy on actively induced and T-line mediated EAE of the Lewis rat

scientific article published on 01 February 1989

Immunspezifische Interaktion von Ratten-Hirnkapillarendothelzellen mit syngenen Antigen-spezifischen T-Zellinien

Importance of integrin LFA-1 deactivation for the generation of immune responses

scientific article

Improving outcome after stroke: overcoming the translational roadblock

scientific article published on 22 February 2008

Influence of Corticosteroids on Neutrophils, Lymphocytes, Their Subsets, and T-Cell Activity Markers in Patients with Active Rheumatoid Arthritis, Compared to Healthy Controls

scientific article published on 01 June 1999

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis

scientific article published on 14 October 2015

Interaction of T Lymphocytes with Cerebral Endothelial Cells in vitro ⬇️

scientific article published on January 1, 1991

Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro.

scientific article

Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

scientific article published on 01 January 2019

Interferon-beta 1b leads to a short-term increase of soluble but long-term stabilisation of cell surface bound adhesion molecules in multiple sclerosis

scientific article

Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro

scientific article published in August 2004

Interferon-beta stabilizes barrier characteristics of the blood-brain barrier in four different species in vitro

scientific article published on 27 May 2008

Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration

scientific article

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH).

scientific article published in August 2016

Introduction

Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study

scientific article published on 23 January 2015

Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells

scientific article

L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis

scientific article published on 01 August 2008

Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis.

scientific article

Leukocyte Trafficking

Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo

scientific article

Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis.

scientific article

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation

scientific article published on 10 July 2012

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.

scientific article published on 28 January 2016

Lymphocytes infiltrating the CNS during inflammation display a distinctive phenotype and bind to VCAM-1 but not to MAdCAM-1.

scientific article published in March 1995

Lysis of rat brain microvascular endothelial cells mediated by resting but not activated MBP-specific CD4+ T cell lines.

scientific article published on November 1994

Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

scientific article

Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of β2-integrins and murine DC-SIGN homologues

scholarly article by Klaus Wethmar et al published October 2006 in European Journal of Immunology

Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers

scientific article

Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier.

scientific article published on 29 January 2016

Molecular mechanisms involved in T cell migration across the blood-brain barrier.

scientific article

Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis

scientific article published on 04 September 2020

Mouse CD99 participates in T-cell recruitment into inflamed skin

scientific article

Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis

scientific article published on June 2003

Neuroscience. Blood-brain barrier differentiation

scientific article published in December 2011

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.

scientific article

Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases

scientific article (publication date: September 2014)

Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia

scientific article published on 27 October 2016

Novel insights into the development and maintenance of the blood-brain barrier

scientific article published on 04 March 2014

Novel mechanisms of the transendothelial migration of leukocytes

scientific article published on 01 August 2001

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.

scientific article

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

scientific article published on 05 April 2019

PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.

scientific article published on 11 May 2014

PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice

article

PSGL-1--the hidden player in T cell trafficking into the brain in multiple sclerosis?

scientific article published in November 2009

Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho

scientific journal article

Polyoma virus middle-T-transformed PECAM-1 deficient mouse brain endothelial cells proliferate rapidly in culture and form hemangiomas in mice.

scientific article published on January 2005

Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro

scientific article published on 24 June 2016

Private immune protection at the border of the central nervous system

scientific article

Prolonged Eosinophil Accumulation in Allergic Lung Interstitium of ICAM-2-Deficient Mice Results in Extended Hyperresponsiveness

article

Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers

scientific article published on 18 July 2019

Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences

scientific article published on 29 July 2016

Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain

scientific article published on February 2011

Serum cytokine levels do not correlate with disease activity and severity assessed by brain MRI in multiple sclerosis

scientific article published in April 2002

Soluble and cell surface ICAM-3 in blood and cerebrospinal fluid of patients with multiple sclerosis: influence of methylprednisolone treatment and relevance as markers for disease activity

scientific article published on 01 February 2000

Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments

scientific article published on 22 January 2016

Strategies to advance translational research into brain barriers

scientific article published on January 2008

Stroke research priorities for the next decade--A representative view of the European scientific community

scientific article published in January 2006

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers

scientific article published on 29 October 2019

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

scientific article published on 25 November 2020

T cell interaction with ICAM-1-deficient endothelium in vitro: transendothelial migration of different T cell populations is mediated by endothelial ICAM-1 and ICAM-2

scientific article published on 01 September 1999

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis

scientific article published on 9 February 2016

T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells

scientific article published on 31 July 2003

T-cell trafficking in the central nervous system

scientific article published on July 2012

TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis

scientific article published on 10 February 2011

TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply

scientific article published on 14 November 2017

The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis ⬇️

scientific article published on 21 March 2019

The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis

scientific article published on 14 March 2006

The anatomical and cellular basis of immune surveillance in the central nervous system.

scientific article published on 20 August 2012

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.

scientific article published on 25 September 2009

The blood-central nervous system barriers actively control immune cell entry into the central nervous system

scientific article published in January 2008

The brain barriers as therapeutic targets in neuroinflammation

scientific article published on 15 November 2013

The choroid plexus is a key cerebral invasion route for T cells after stroke.

scientific article published on 31 July 2017

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

scientific article

The movers and shapers in immune privilege of the CNS.

scientific article published on 16 January 2017

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

scientific article

Therapeutic targeting of leukocyte trafficking across the blood-brain barrier

scientific article published on December 2007

Tight Junctions in Brain Barriers During Central Nervous System Inflammation ⬇️

scientific article published on May 25, 2011

Transfer of the sFLT-1 gene in Morris hepatoma results in decreased growth and perfusion and induction of genes associated with stress response

scientific article published in March 2005

Ultrastructural localization of adhesion molecules in the healthy and inflamed choroid plexus of the mouse.

scientific article

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.

scientific article

Vascular, glial, and lymphatic immune gateways of the central nervous system

scientific article

Wiring the Vascular Network with Neural Cues: A CNS Perspective

scientific article (publication date: 15 July 2015)

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro

scientific article (publication date: 2013)

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

article by Peter Vajkoczy et al published 15 August 2001 in Journal of Clinical Investigation

β1-integrin/matrix interactions support blood-brain barrier integrity.

scientific article published on 20 July 2011

β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier

scientific article published on 20 November 2013

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